Association of serum sialic acid and MMP‐9 with lipids and inflammatory markers

Kalela, Anne; Pönniö, Maritta; Koivu, Tommi A.; Höyhtyä, Matti; Huhtala, Heini; Sillanaukee, Pekka; Nikkari, Seppo T.

doi:10.1046/j.1365-2362.2000.00607.x

Cited by 36 publications

(26 citation statements)

References 33 publications

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“…Abdella et al [29] showed significant correlations between TSA concentrations and cardiovascular risk factors such as LDL cholesterol, triglycerides and apolipoprotein B in diabetic adults. Another study showed that TSA was significantly associated with lipid and lipoprotein concentrations in normal subjects [30]. In contrast, our findings showed no association between serum lipids and lipoproteins in our obese population aged 6–16 years.…”

Section: Discussioncontrasting

confidence: 97%

The Association of Serum Sialic Acid with Carotid Intima-Media Thickness and Anthropometric and Metabolic Parameters in Obese Children and Adolescents

Akın¹,

Kurtoğlu²,

Muhtaroğlu

et al. 2011

Ann Nutr Metab

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Background: Sialic acid (SA) has been shown to be a strong predictor of cardiovascular mortality in adults. No study in children regarding the association of SA with cardiovascular risks exists in the literature. Aim: We aimed to investigate the association of SA with anthropometric and metabolic parameters and its correlation with metabolic syndrome (MS) and carotid intima-media thickness (IMT) in obese children. Methods: A total of 154 obese children were included in the study (74 females, 80 males; mean age 11.3 ± 2.6 years). Anthropometric measurements including body fat percentage (BFP) were recorded. Fasting lipids and SA levels were measured. The carotid IMT was evaluated with ultrasonography. Results: We found a significant correlation between serum total SA (TSA) levels and BFP (r = 0.25, p = 0.01 in the whole group; r = 0.43, p = 0.00 in girls). The group with BFP ≧95th percentile had higher TSA levels than the group with BFP <95th percentile (p = 0.04). TSA and carotid IMT were weakly correlated (r = 0.20, p = 0.01), but the significance was lost after correcting for BFP. No correlations were found between TSA and other anthropometric measurements. TSA did not correlate with serum fasting glucose, lipids, insulin or homeostasis model assessment-insulin resistance. TSA levels were not different between children with or without MS. Conclusion: Serum TSA levels are significantly correlated with BFP in obese children.

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Section: Discussioncontrasting

confidence: 97%

The Association of Serum Sialic Acid with Carotid Intima-Media Thickness and Anthropometric and Metabolic Parameters in Obese Children and Adolescents

Akın¹,

Kurtoğlu²,

Muhtaroğlu

et al. 2011

Ann Nutr Metab

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“…In one report, baseline MMP-9 was associated with lower HDL cholesterol, 19 but no association of MMP-9 and HDL cholesterol was observed in another report. 28 A positive association of MMP-9 and WBC was observed in one report. 28 Additional studies need to be done on the epidemiological correlations of circulating MMP-9.…”

Section: Discussionmentioning

confidence: 82%

“…28 A positive association of MMP-9 and WBC was observed in one report. 28 Additional studies need to be done on the epidemiological correlations of circulating MMP-9.…”

Section: Discussionmentioning

confidence: 82%

Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus

et al. 2002

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Background-Markers of systemic inflammation (eg, C-reactive protein [CRP] and interleukin-6 [IL-6]) have been proposed to be "nontraditional" risk factors for cardiovascular disease in patients with type 2 diabetes mellitus. Matrix metalloproteinase-9 (MMP-9) has been implicated in the pathogenesis of atherosclerotic plaque rupture, which raises the possibility of the use of MMP-9 levels as a marker for future myocardial infarction or unstable angina. In vitro and animal studies suggest that thiazolidinediones can reduce the expression of these markers. The purpose of this analysis was to determine whether rosiglitazone alters serum concentrations of CRP, IL-6, MMP-9, and white blood cell count (WBC) and to examine the relationship of these effects with demographic and disease variables. Methods and Results-CRP, IL-6, MMP-9, and WBC were analyzed from stored frozen serum samples obtained from patients with type 2 diabetes who completed a 26-week randomized, double-blind, placebo-controlled study. After 26 weeks of rosiglitazone treatment, the percentage reductions in mean CRP, MMP-9, and WBC levels were statistically significant compared with baseline and placebo (PϽ0.01). The percentage reduction in mean IL-6 was small and similar in the rosiglitazone and placebo groups. The change in each inflammatory marker from baseline to week 26 was significantly correlated (PϽ0.05) with each of the other markers, as well as with the homeostasis model assessment estimate of insulin resistance. Conclusions-Rosiglitazone reduces serum levels of MMP-9 and the proinflammatory marker CRP in patients with type 2 diabetes, which indicates potentially beneficial effects on overall cardiovascular risk.

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“…13 Such a lack of correlation was equally observed for circulating levels of another metalloproteinase, MMP-9, in normolipidemic subjects apparently free of atherosclerosis 14 and in patients with premature coronary atherosclerosis. 15 Thus, the report of Bayes-Genis et al 9 and our present studies are concordant in identifying elevated serum PAPP-A levels as a marker of unstable or advanced hyper/isoechoic carotid atherosclerotic lesions, because early hypoechoic plaques are not associated with an elevation in circulating PAPP-A levels.…”

Section: Discussionmentioning

confidence: 97%

Serum Plasma Pregnancy-Associated Protein A

Beaudeux

Burc

Imbert‐Bismut

et al. 2003

ATVB

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Objective-The proteolytic activity of metalloproteinases, proinflammatory enzymes that degrade extracellular matrix, is elevated in lipid-rich atherosclerotic plaques, thereby contributing to plaque fragility and rupture. Pregnancy-associated plasma protein (PAPP-A) is a metalloproteinase, expressed in unstable atherosclerotic plaques, whose circulating levels are elevated in acute coronary syndromes. We evaluated serum PAPP-A levels as a marker of the premature development of atherosclerosis in hyperlipidemic subjects at elevated cardiovascular risk. Methods and Results-Serum PAPP-A levels were determined in asymptomatic hyperlipidemic male subjects (nϭ64; meanϮSD age, 51Ϯ7 years) in whom intima-media thickness (IMT) and lesion status in the carotid artery were evaluated by noninvasive ultrasonography and compared with those of a normolipidemic control group (nϭ25). No difference was observed in circulating PAPP-A levels between hyperlipidemic subjects and controls (8.99Ϯ2.93 and 8.03Ϯ2.75 mIU/L, respectively; meanϮSD) nor between hyperlipidemic subjects who presented with a luminal obstruction of the carotid artery (9.26Ϯ2.53 mIU/L) and those who did not (8.85Ϯ3.29 mIU/L). By contrast, in patients with atheromatous carotid plaques, a positive association between serum levels of PAPP-A and C-reactive protein was observed (PϽ0.05); moreover, subjects exhibiting hyperechoic or isoechoic, echogenic lesions had significantly higher PAPP-A levels compared with those with hypoechoic lesions (10. Key Words: pregnancy-associated plasma protein A Ⅲ metalloproteinase Ⅲ hyperlipidemia Ⅲ carotid atherosclerosis I nflammation plays a key role in the initiation, progression, and rupture of the atherosclerotic plaque. 1,2 Several systemic proteins have been proposed as markers of a chronic inflammatory state in the arterial wall, including highsensitive C-reactive protein (hsCRP), serum amyloid A protein, and soluble adhesion molecules. 3-5 Elevated levels of hsCRP were shown to be predictive of peripheral or coronary atherosclerosis 3 and to constitute an independent predictor of advanced carotid plaques in dyslipidemic subjects. 6 Matrix metalloproteinases (MMPs), a family of interstitial proteolytic enzymes that regulate remodeling of extracellular matrix, might also constitute potential biological markers of the inflammatory process occurring during atherosclerosis. Several MMPs were found to be overexpressed in atherosclerotic lesions, thereby contributing to their progression and rupture. 7 Pregnancy-associated plasma protein A (PAPP-A) is a high-molecular-weight, zinc-binding metalloproteinase that is typically measured during pregnancy in maternal blood for the fetal diagnosis of Down syndrome. However, circulating PAPP-A is physiologically present in both men and women; moreover, it is abundantly expressed in advanced atherosclerotic lesions and constitutes a specific activator of insulin-like growth factor, a mediator of atherosclerosis. 8 Peripheral blood levels of PAPP-A have been recently proposed as a biological...

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Association of serum sialic acid and MMP‐9 with lipids and inflammatory markers

Cited by 36 publications

References 33 publications

The Association of Serum Sialic Acid with Carotid Intima-Media Thickness and Anthropometric and Metabolic Parameters in Obese Children and Adolescents

The Association of Serum Sialic Acid with Carotid Intima-Media Thickness and Anthropometric and Metabolic Parameters in Obese Children and Adolescents

Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus

Serum Plasma Pregnancy-Associated Protein A

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