Association of serum soluble Fas concentrations and mortality of septic patients

Lorente, Leonardo; Martı́n, Marı́a; Ortiz-López, Raquel; González-Rivero, Agustín F.; Pérez-Cejas, Antonia; Pastor, Eduardo; Domínguez-Curell, Claudia; Raja, Lorena; Lorenzo, L; Jiménez, Alejandro

doi:10.1016/j.eimc.2020.08.003

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…First, the association between serum levels of sFas and Bcl2 and mortality is present in all regression models (controlling for SOFA or APACHE-II). Second, those high serum sFas concentrations and low serum Bcl2 concentrations in non-survivor patients are in line with the poor prognosis found in septic patient patients [ 18 , 19 ]. We think all those findings could motivate the research on apoptosis in COVID-19 patients.…”

Section: Discussionmentioning

confidence: 80%

“…However, we have not found data about the association between apoptosis and mortality of COVID-19 patients. We had previously found a higher mortality in septic patients with high serum sFas concentrations [ 18 ] and low serum Bcl2 concentrations [ 19 ]. Thus, the objective of this study was to analyze whether there is an association between serum concentrations of sFas and Bcl2 and mortality of COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

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Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality

Lorente

Martı́n

González-Rivero

et al. 2021

Expert Review of Molecular Diagnostics

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Background: There are no data on circulating concentrations of sFas (proapoptotic protein of extrinsic pathway) and Bcl2 (antiapoptotic protein of intrinsic pathway) in COVID-19 patients. Thus, our objective study was to determine whether an association exists between serum concentrations of sFas and Bcl2 and COVID-19 patient mortality. Methods: This observational and prospective study of COVID-19 patients was performed in eight Intensive Care Units (ICU) from Canary Islands (Spain). Serum levels of sFas and Bcl2 at ICU admission were determined. Mortality at 30 days was the end-point study. Results: Surviving patients ( n = 42) compared to non-surviving ( n = 11) had lower APACHE-II ( p < 0.001), lower SOFA ( p = 0.004), lower serum sFas levels ( p = 0.001) and higher serum Bcl2 levels ( p < 0.001). Logistic regression showed an association between high serum sFas levels and mortality after controlling for APACHE-II (OR = 1.004; 95% CI = 1.101–1.007; p = 0.01) or SOFA (OR = 1.003; 95% CI = 1.101–1.106; p = 0.004), and between low serum Bcl2 levels and mortality after controlling for APACHE-II (OR = 0.927; 95% CI = 0.873–0.984; p = 0.01) or SOFA (OR = 0.949; 95% CI = 0.913–0.987; p = 0.01). Conclusions: Thus, to the best of our knowledge, this is the first study reporting blood levels of sFas and Bcl2 in COVID-19 patients and its association with mortality.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality

Lorente

Martı́n

González-Rivero

et al. 2021

Expert Review of Molecular Diagnostics

Self Cite

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“…Whelan et al have suggested that level of apoptosis in the healthy heart is very small -about 0.001%-0.002% (5), but only an enhancement of 0.023% in apoptosis due to the increased caspase8 in rat myocardium causes dilated cardiomyopathy after two to six months (6). Programmed cell death occurs through two pathways that both of which lead to the activation of caspase 3 and breakdown of cellular components (7)(8)(9). There is no conclusive evidence to confirm that obesity-induced apoptosis is activated by any intrinsic or extrinsic pathways.…”

Section: Introductionmentioning

confidence: 99%

The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats

Astani

Bashiri

Pourrazi

et al. 2022

Hormozgan medical journal

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Background: Diet-induced obesity is associated with several cardiovascular diseases and myocardial apoptosis. This study aimed to investigate the effect of high intensity interval training (HIIT) on the myocardial apoptosis in the diet-induced obese rats. Methods: Thirty-two male rats, after an obesity induction period, were randomly selected and assigned to four groups including non-obese control (NOC; n=8), basal obese control (BOC; n=8), obese control (OC; n=8), and obese+HIIT (OT; n=8). NOC and BOC groups were sacrificed before the training period. The OT group underwent a HIIT program performed 5 times/week over 12 weeks. Rat hearts were removed 48 hours after the last training session. The Bax, Bcl-2, cytochrome-c, Bid, caspase-8, as well as caspase-3 protein expressions were analyzed using western blotting. Data were analyzed using independent t test. Results: After obesity induction period, the Bax, Bid, cytochrome-c, caspase-8, caspase-3 proteins, and Bax/Bcl-2 in BOC were found to be significantly higher than those in NOC (P=0.025, P=0.0001, P=0.013, P=0.017, P=0.01, P=0.18, respectively). However, Bcl-2 protein in BOC was detected to be significantly lower than that in NOC (P=0.025). The results obtained after completing HIIT training showed that Bid, cytochrome-c, caspase-8, caspase-3, and Bax/Bcl-2 in OT were lower than those in OC (P=0.005, P=0.039, P=0.001, P=0.04, P=0.05, respectively). However, Bcl-2 protein in OT was significantly higher than that in OC (P=0.004). No significant difference was found between OT and OC regarding Bax protein (P=0.32). Conclusion: Diet-induced obesity may have exacerbated the myocardial apoptosis through both intrinsic and extrinsic pathways. However, it seemed that HIIT training significantly prevented the increase of myocardial apoptosis in obese rats.

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IL-6, IL-10, sFas, granulysin and indicators of intestinal permeability as early biomarkers for a fatal outcome in COVID-19

Hernández-Solís

Güemes-González²,

Ruiz-Gómez³

et al. 2022

Immunobiology

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Association of serum soluble Fas concentrations and mortality of septic patients

Cited by 4 publications

References 22 publications

Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality

Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality

The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats

IL-6, IL-10, sFas, granulysin and indicators of intestinal permeability as early biomarkers for a fatal outcome in COVID-19

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