Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status

Sayar, Ferena; Akhondi, Nasrin; Fallah, Soltanali; Moalemnia, Amir Abbas; Cheraghi, Azra

doi:10.1902/jop.2016.160366

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…We found no significant difference in periodontitis risk between the fibrate monotherapy and control groups. Similarly, Sayar et al 20 . reported no significant difference in periodontal parameters between fibrate users and nonusers in patients with hypertriglyceridemia.…”

Section: Discussionmentioning

confidence: 93%

“…We found no significant difference in periodontitis risk between the fibrate monotherapy and control groups. Similarly, Sayar et al 20 reported no significant difference in periodontal parameters between fibrate users and nonusers in patients with hypertriglyceridemia. Although most studies show local delivery of antihyperlipidemic agents (mostly statins) improved the periodontal treatment outcome, 14 systemic statins or fibrate monotherapy did not influence the incidence of chronic periodontitis in patients with hyperlipidemia in our study.…”

Section: Eventsmentioning

confidence: 94%

“…Patients with periodontitis receiving local or systemic statins as an adjuvant to periodontal treatment exhibit more favorable therapeutic outcomes than those receiving periodontal therapy alone. [13][14][15][16] Although a few studies have evaluated the effect of antihyperlipidemic agents (statins or fibrates) on the periodontal status of patients with hyperlipidemia (who are at risk of periodontitis), [17][18][19][20][21] their results have been conflicting. Moreover, most of them were cross-sectional studies, [17][18][19][20] precluding the determination of the temporal relationship between medication use and disease occurrence.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15][16] Although a few studies have evaluated the effect of antihyperlipidemic agents (statins or fibrates) on the periodontal status of patients with hyperlipidemia (who are at risk of periodontitis), [17][18][19][20][21] their results have been conflicting. Moreover, most of them were cross-sectional studies, [17][18][19][20] precluding the determination of the temporal relationship between medication use and disease occurrence. The only longitudinal study 21 conducted was not restricted to patients with hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

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Association between antihyperlipidemic agents and the risk of chronic periodontitis in patients with hyperlipidemia: A population‐based retrospective cohort study in Taiwan

Wang,

Lin,

Keller

et al. 2023

Journal of Periodontology

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BackgroundThe lipid‐lowering and anti‐inflammatory effects of statins and fibrates may ameliorate periodontitis. Patients with hyperlipidemia tend to have a worse periodontal status. This study assessed the association between the use of statins/fibrates and the incidence of chronic periodontitis in patients with hyperlipidemia in Taiwan.MethodsThis retrospective cohort study enrolled patients newly diagnosed with hyperlipidemia between 2001 and 2012 from the 2000 Longitudinal Generation Tracking Database and followed them for 5 years. The study population was divided into four groups: statin monotherapy, fibrate monotherapy, combination therapy (both statins and fibrates), and control (neither statins nor fibrates). Each patient in the treatment group was matched at a ratio of 1:1 with a control. Chronic periodontitis risk was compared in the three study arms by using a Cox proportional hazard model.ResultsChronic periodontitis risk was reduced by 25.7% in the combination therapy group compared with the control group (adjusted hazard ratio [aHR], 0.743; 95% confidence interval (CI), 0.678–0.815). Low dose (<360 cumulative defined daily dose [cDDD]) and shorter duration (<2 years) of statin monotherapy seem to be associated with an increased risk of chronic periodontitis; high dose (≥720 cDDD/≥1080 cDDD) and longer duration (≥3 years) of statin/fibrate monotherapy may be correlated with a lower risk of periodontitis. Hydrophobic statin users had a lower chronic periodontitis risk than hydrophilic statin users.ConclusionChronic periodontitis risk was lower in patients with hyperlipidemia on combination treatment with statins and fibrates, and the risk decreased when patients used statins or fibrates for >3 years.

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Section: Discussionmentioning

confidence: 93%

Section: Eventsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between antihyperlipidemic agents and the risk of chronic periodontitis in patients with hyperlipidemia: A population‐based retrospective cohort study in Taiwan

Wang,

Lin,

Keller

et al. 2023

Journal of Periodontology

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“…However, no such association was found with periodontitis risk in male subjects ( 8 ). In the case of hyperlipidemia combined with periodontitis, the probing depth (PD) and clinical attachment loss (CAL) of patients were positively correlated with the levels of TG, TC, and LDL-C ( 9 , 10 ). Another cross-sectional study also showed that in patients with chronic periodontitis, the level of apolipoprotein B (apo B) in gingival crevicular fluid in the infected area was higher than that in the healthy area ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

Hu,

Song,

Yang

et al. 2023

Front. Endocrinol.

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IntroductionThe correlation between dyslipidemia and periodontitis is revealed through epidemiological studies. However, the results are affected by several confounding factors. This study aims to elucidate the genetic causal association between circulating lipid traits and periodontitis by two-sample Mendelian randomization (MR) analysis.MethodsAfter the different screening processes, two cohorts of circulating lipid traits from the UK Biobank were used as exposure data, including five circulating lipid traits. The Periodontitis cohort was selected from the GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium as outcome data. In univariable MR, the inverse variance weighted (IVW) was used in conjunction with six additional analytical methods to assess causality. The Cochran Q test, IGX2 statistic, MR-PRESSO, and MR-Egger intercept were used to quantify heterogeneity and pleiotropy. The multivariable MR-IVW (MVMR-IVW) and MVMR-robust were mainly used as analytical methods in the multiple MR analyses.ResultsThe IVW estimates showed that genetically predicted Apolipoprotein A1 (apo A1) [odds ratio (OR)=1.158, 95% confidence interval (CI)=1.007–1.331, P-value=0.040] was potentially associated with the risk of periodontitis, but the statistical power of the results was low. Multivariable MR analysis did not reveal any significant causal relationship between apo A1 and periodontitis (OR=0.72, 95% CI=0.36–1.41, P-value=0.34). In the validation cohort, there was also no significant causal relationship between apo A1 and periodontitis (OR=1.079, 95% CI=0.903–1.290, P-value=0.401). Meanwhile, genetically predicted Apolipoprotein B (apo B), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) (all P-values>0.05) were not significantly associated with the risk of periodontitis causal inference.ConclusionThis MR analysis was unable to provide genetic evidence for the influence of these five circulating lipid traits on periodontitis. However, a more extensive study with a more comprehensive circulating lipid profile and periodontitis data is needed due to study limitations.

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Exploring the bi-directional relationship between periodontitis and dyslipidemia: a comprehensive systematic review and meta-analysis

Ma,

Zou,

Yang

et al. 2024

BMC Oral Health

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Aim As periodontitis and dyslipidemia are diseases that occur with high incidence, the relationship between them has attracted much attention. Previous studies on these diseases have tended to focus on lipid parameters and periodontitis, we aimed to investigate the relationship between dyslipidemia and periodontitis. Materials and methods A comprehensive search to identify the studies investigating the relationship between dyslipidemia and periodontitis was performed on PubMed, Web of Science and Cochrane Library before the date of August, 2023. Studies were considered eligible if they contained data on abnormal blood lipid parameters and periodontitis. Studies that reported mean differences and 95% confidence intervals or odds ratios were used. Results A total of 73 publications were included in the meta-analysis. Hyper total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and lower high-density lipoprotein (HDL) levels are risk factors for periodontitis. Periodontal disease is a risk factor for high TG and low HDL levels. Three months after periodontal treatment, the levels of TC, TG and HDL were significantly improved, and statin treatment only improved gingival index (GI) levels compared to that of the dietary control. Conclusions The findings reported here suggest that the mutual promotion of periodontitis and dyslipidemia can be confirmed. Non-surgical periodontal therapy may improve lipid abnormalities. It can’t be demonstrated whether systematic application of statins have a better effect on the improvement in periodontal status in patients with dyslipidemia compared to that of the control.

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Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status

Abstract: Patients with hypertriglyceridemia had worse periodontal status than healthy controls. Patients with hypertriglyceridemia who were taking gemfibrozil did not show significant differences in CAL and PD compared with untreated patients with hypertriglyceridemia.

Cited by 5 publications

References 36 publications

Association between antihyperlipidemic agents and the risk of chronic periodontitis in patients with hyperlipidemia: A population‐based retrospective cohort study in Taiwan

Association between antihyperlipidemic agents and the risk of chronic periodontitis in patients with hyperlipidemia: A population‐based retrospective cohort study in Taiwan

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

Exploring the bi-directional relationship between periodontitis and dyslipidemia: a comprehensive systematic review and meta-analysis

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