Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents

Pacifico, Lucia; Bonci, Enea; Andreoli, G; Romaggioli, Sara; Miscio, Rossella Di; Lombardo, Concetta Valentina; Chiesa, Claudio

doi:10.1016/j.numecd.2014.01.010

Cited by 150 publications

(143 citation statements)

References 27 publications

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“…Furthermore, the TG/HDL-C ratio has been proven to be outstanding in comparison to other indicators to screen for the metabolic syndrome and was found to be a useful marker of early functional and morphological vascular changes (28 )and cardiac remodeling, as well as nonalcoholic fatty liver disease detection in pediatric cohorts (39 ).…”

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confidence: 99%

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Modification and Validation of the Triglyceride-to–HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE)

et al. 2016

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BACKGROUND The triglyceride-to–HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices but their measurement is expensive. Easier and more affordable tools are of interest for both pediatric and adult patients. METHODS Study participants from the Relationship Between Insulin Sensitivity and Cardiovascular Disease [43.9 (8.3) years, n = 1260] as well as the Beta-Cell Function in Juvenile Diabetes and Obesity study cohorts [15 (1.9) years, n = 29] underwent oral-glucose-tolerance tests and euglycemic clamp tests for estimation of whole-body insulin sensitivity and calculation of insulin sensitivity indices. To refine the TG/HDL ratio, mathematical modeling was applied including body mass index (BMI), fasting TG, and HDL cholesterol and compared to the clamp-derived M-value as an estimate of insulin sensitivity. Each modeling result was scored by identifying insulin resistance and correlation coefficient. The Single Point Insulin Sensitivity Estimator (SPISE) was compared to traditional insulin sensitivity indices using area under the ROC curve (aROC) analysis and χ2 test. RESULTS The novel formula for SPISE was computed as follows: SPISE = 600 × HDL-C0.185/(TG0.2 × BMI1.338), with fasting HDL-C (mg/dL), fasting TG concentrations (mg/dL), and BMI (kg/m2). A cutoff value of 6.61 corresponds to an M-value smaller than 4.7 mg · kg−1 · min−1 (aROC, M:0.797). SPISE showed a significantly better aROC than the TG/HDL-C ratio. SPISE aROC was comparable to the Matsuda ISI (insulin sensitivity index) and equal to the QUICKI (quantitative insulin sensitivity check index) and HOMA-IR (homeostasis model assessment–insulin resistance) when calculated with M-values. CONCLUSIONS The SPISE seems well suited to surrogate whole-body insulin sensitivity from inexpensive fasting single-point blood draw and BMI in white adolescents and adults.

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confidence: 99%

“…In addition, our study predominantly recruited Europeans of white ethnicity. Given the differences of lipoprotein metabolism between white and African American populations mentioned above (12,37,39 ), for the time being SPISE can be applied only to white people, with validation in other populations, in particular African Americans, needed.…”

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confidence: 99%

Modification and Validation of the Triglyceride-to–HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE)

et al. 2016

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“…Low HDL cholesterol and high triacylglycerol levels are known to be associated with cardiovascular diseases and diabetes mellitus type 2 [28,29]. Moreover, some authors reported that TG/HDL-C ratio could help to identify patients at high risk for metabolic disturbances and structural changes in blood vessels [30]. However, more clinical studies are needed to better understand these effects, especially in the paediatric population.…”

Section: Discussionmentioning

confidence: 99%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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A b s t r a c tIntroduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods: The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results: Children with headaches had higher BMI z-scores (0.2 vs. -1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions: Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.

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“…The authors also determined that compared with other lipid ratios (cholesterol/HDL and LDL/HDL), the TG/HDL ratio most accurately predicted advanced liver disease. Pacifico et al (8) stratified subjects into consecutive TG/HDL-C tertiles. Their findings revealed significantly higher odds ratios for NAFLD as TG/HDL-C ratio tertiles increased.…”

Section: Discussionmentioning

confidence: 99%

“…Lipoprotein ratios are considered to be of greater use than isolated lipid values in the assessment of cardiovascular risk in adult patients, since these constitute a more accurate reflection of the interactions between lipid fractions (5). Although NAFLD is known to be a major risk factor for cardiovascular disease, there has been little investigation of the clinical value of lipid ratios in this condition, particularly in the pediatric age group (6)(7)(8)(9). Studies concerning IR and triglyceride-(TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) have revealed a clear association between them, and TG/HDL ratio was found to be significantly correlated with IR (10).…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Triglyceride-to-High-density Lipoprotein Cholesterol Ratio with Insulin Resistance and Non-alcoholic Fatty Liver Disease in Children and Adolescents

Üstyol¹,

Kokali²,

Duru³

et al. 2018

Haseki

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Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents

Cited by 150 publications

References 27 publications

Modification and Validation of the Triglyceride-to–HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE)

Modification and Validation of the Triglyceride-to–HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE)

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Association of Serum Triglyceride-to-High-density Lipoprotein Cholesterol Ratio with Insulin Resistance and Non-alcoholic Fatty Liver Disease in Children and Adolescents

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