Association of serum undercarboxylated osteocalcin with serum estradiol in pre-, peri- and early post-menopausal women

Uemura, Hirokazu; Tomita, Junko; Miyatani, Yuka; Yamada, Masayo; Miura, Masaru; Irahara, Minoru

doi:10.1007/bf03349196

Cited by 30 publications

(13 citation statements)

References 23 publications

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“…After adjusting for age and BMI, differences are also found in the serum FSH and LH levels of Asian women [26], suggesting that the relationship between the pituitary and ovarian hormones is affected by racial differences [19]. Our research has confirmed that serum FSH and LH levels in Chinese women are positively correlated with both bone formation indicators (BAP and OC) and bone resorption indicators (sNTX, sCTX, uNTX, uCTX, and uDPD), suggesting that the bone turnover speed becomes more rapid in women with increasing FSH and LH levels in circulation; this finding is similar to those of other studies [10,[27][28][29]. In contrast, however, Vural et al [15] found that serum FSH and LH levels are not correlated with the bone formation marker OC.…”

Section: Discussionsupporting

confidence: 91%

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Xie

et al. 2009

Osteoporos Int

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Section: Discussionsupporting

confidence: 91%

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Xie

et al. 2009

Osteoporos Int

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“…On the other hand, it is well established that serum osteocalcin levels are influenced by ethnicity, sex, and menopause status. 25,26 Recent studies of this relationship in the Chinese population have been limited to individuals with obvious symptoms and to those undergoing coronary angiography. Results have demonstrated that serum osteocalcin levels are significantly lower in the CHD group that in the non-CHD group and significantly decrease with increasing number of diseased vessels.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum osteocalcin levels and carotid intima-media thickness in Chinese postmenopausal women

Yang

Dou³

et al. 2013

Menopause

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“…Yasui et al reported that serum ucOC levels were inversely correlated with serum estradiol levels [21]. They also reported in their longitudinal study that serum ucOC levels and the ucOC/OC ratio increased more rapidly than serum OC levels after bilateral oophorectomy [12].…”

Section: Discussionmentioning

confidence: 90%

Androgen Deprivation Therapy Induces Vitamin K Loss in Men with Prostate Cancer

Matsushima¹

2017

Biol Med

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Bone strength is determined by bone mineral density (BMD) and bone quality. Bone fractures are serious adverse events in men receiving androgen deprivation therapy (ADT) for prostate cancer. Although it is established that ADT reduces BMD, it is unclear how ADT alters bone quality. Vitamin K is a bone quality marker which aids to carboxylates osteocalcin to form bone matrix. Serum undercarboxylated osteocalcin (ucOC) is accumulated in vitamin K deficiency, which is used as a surrogate for vitamin K status. As little is known as to the impact of ADT on serum ucOC, we investigated the changes of serum ucOC in PC patients during ADT. Fifty consecutive hormone naïve PC patients were enrolled. Serum ucOC, serum osteocalcin (OC), serum Nteloptide of type 1 collagen (NTx) and hip bone mineral density (BMD) were measured at baseline, 6 month and 12 months since the start of ADT. Serum ucOC levels at 6 and 12 months (3.86 ± 2.28 and 4.32 ± 1.76 ng/ml) were significantly higher than those at baseline (2.46 ± 1.46 ng/ml). Serum OC levels at 12 months (7.82 ± 2.65 ng/ml) were significantly higher than those at baseline (5.26 ± 1.86 ng/ml). Furthermore, the ratio of ucOC/OC at 1 year (0.54 ± 0.15) were significantly higher than at baseline (0.42 ± 0.18). Both serum NTx levels and hip BMDs at 6 and 12 months were also significantly higher than those at baseline. Our results first demonstrated that ADT induced vitamin K loss in men with prostate cancer. Further investigations are required to determine whether vitamin K supplement is useful to prevent bone fractures in men on ADT.

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Association of serum undercarboxylated osteocalcin with serum estradiol in pre-, peri- and early post-menopausal women

Abstract: The results showed that the change in ucOC concentration during the menopausal transition is different from that in OC concentration. In addition, serum ucOC concentration is closely associated not only with FSH concentration but also estradiol concentration.

Cited by 30 publications

References 23 publications

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Relationship between serum osteocalcin levels and carotid intima-media thickness in Chinese postmenopausal women

Androgen Deprivation Therapy Induces Vitamin K Loss in Men with Prostate Cancer

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