Association of serum uric acid levels with SYNTAX score II and long term mortality in the patients with stable angina pectoris who undergo percutaneous coronary interventions due to multivessel and/or unprotected left main disease

Karabağ, Yavuz; Rencüzoğulları, İbrahim; Çağdaş, Metin; Karakoyun, Süleyman; Yesi̇n, Mahmut; Atalay, Eray; Çağdaş, Öznur Sadioğlu; Gürsoy, Mustafa Ozan; Burak, Cengiz; Tanboğa, Halil İbrahim

doi:10.1007/s10554-018-1446-6

Cited by 13 publications

(12 citation statements)

References 36 publications

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“…The most important issue in these subjects is the possible relationship between UA levels and the extent and severity of Coronary Artery Disease (CAD). As was also shown in Table 2 , most of the publications on this topic show that UA correlates with CAD, as defined as both the number of vessels involved [ 48 ] and specific scores, such as Gensan [ 49 ] or Syntax [ 50 ]. However, other studies did not identify this association [ 9 , 51 , 52 ].…”

Section: Uric Acid and Chronic Coronary Syndromementioning

confidence: 99%

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

Maloberti

Biolcati

Ruzzenenti

et al. 2021

JCM

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Uric acid (UA) is the final product of the catabolism of endogenous and exogenous purine nucleotides. While its association with articular gout and kidney disease has been known for a long time, new data have demonstrated that UA is also related to cardiovascular (CV) diseases. UA has been identified as a significant determinant of many different outcomes, such as all-cause and CV mortality, and also of CV events (mainly Acute Coronary Syndromes (ACS) and even strokes). Furthermore, UA has been related to the development of Heart Failure, and to a higher mortality in decompensated patients, as well as to the onset of atrial fibrillation. After a brief introduction on the general role of UA in CV disorders, this review will be focused on UA’s relationship with CV outcomes, as well as on the specific features of patients with ACS and Chronic Coronary Syndrome. Finally, two issues which remain open will be discussed: the first is about the identification of a CV UA cut-off value, while the second concerns the possibility that the pharmacological reduction of UA is able to lower the incidence of CV events.

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Section: Uric Acid and Chronic Coronary Syndromementioning

confidence: 99%

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

Maloberti

Biolcati

Ruzzenenti

et al. 2021

JCM

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“… (Gaubert et al, 2018) 37 Endothelial dysfunction with reactive hyperemia (RH) and severity of atherosclerosis Non-invasive peripheral arterial tonometry (PAT) and angiography The uric acid level had a significant relationship with Reactive Hyperemia Index/RHI (β= -0.17, p<0.001), and the uric acid level was associated with the Gensini score and SYNTAX score (p<0.001) (Joo et al, 2018) 27 Major adverse event (MAE): the cause of all mortality, non-fatal myocardial infarction, and revascularization. Angiography Uric acid was not an independent predictor of MAE (HR 1.110; 95% CI 0.980-1.257; p= 0.100) (Karabağ et al, 2019) 39 SYNTAX score II (SII) and long-term mortality Angiography Uric acid and SYNTAX independent predictors of long-term mortality (HR 1.24, 95% CI 1.046-1.482, p= 0.014; HR 1.042, 95% CI 1.007-1.079, p= 0.018) …”

Section: Resultsmentioning

confidence: 99%

The Potential of Prognostic Biomarkers of Uric Acid Levels in Coronary Heart Disease Among Aged Population: A Scoping Systematic Review of the Latest Cohort Evidence

Maulana¹,

Nuraeni²,

Nugraha³

2022

JMDH

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Background This study sought to determine whether uric acid levels have a relationship with and can potentially be used as a prognosis for coronary heart disease (CHD) biomarkers using a scoping review. Methods This study was conducted following Arksey and O’Malley’s scoping review framework. It was reported as obeying the Preferred Reporting Item for Systematic Review and Meta-analysis for Scoping Review (PRISMA-ScR). The subject was extensively searched for in PubMed, CINAHL, and ScienceDirect. The inclusion criteria in the study were that the sources were journal articles written in English and were available in full text. The age of the subject in the item is the elderly population to capture the relationship between uric acid levels and the prognosis of CHD. The publication time limit was 2010 to 2020. The study was analyzed using thematic analysis. Results We identified 592 studies in our initial search, and 21 studies with a cohort design were included in this study’s analysis. The majority of the evidence suggests an independent correlation with a poor prognosis of CHD in the elderly population. The prognosis of gout includes the prognosis of clinical outcome, severity, and mortality, all of which influence the prognosis value, which becomes a marker. Conclusion Uric acid levels have been identified as a potential biomarker for poor CHD prognosis. Nurses and other healthcare workers should learn how to control poor CHD prognosis.

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“…In a study involving 64 aortic stenosis patients, Demir B et al found a significant relationship between CAVD and elevated uric acid level, which they accepted as an indirect indicator of increased oxidative stress and endothelial dysfunction [21]. In addition to this, uric acid was shown to promote development of atherosclerosis via inducing inflammation and also associated with the disease severity and prognosis in atherosclerotic patients [22,23]. All these data and our current findings suggest that uric acid may have a role in the development of aortic sclerosis and CAVD.…”

Section: Discussionmentioning

confidence: 99%

Periaortic adipose tissue volume is associated with sclerotic changes in the adjacent aortic valve

Mustu

Gürses

Alpaydın

et al. 2020

Int J Cardiovasc Imaging

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Aortic sclerosis is associated with increased cardiovascular mortality and morbidity. Numerous studies have shown that visceral adiposity is associated with development of atherosclerosis, especially in the adjacent vascular wall. Considering the similar pathophysiology of aortic sclerosis and atherosclerosis, it can be hypothesized that visceral adipose tissue adjacent to aortic valve may be associated with aortic sclerosis. In this study, we investigated the relationship between periaortic adipose tissue volume and sclerotic changes in the adjacent aortic valve. In this retrospective study, 80 patients with a concurrent MSCT and echocardiography in the last 6 months were enrolled. Echocardiographic examinations were retrospectively evaluated regarding the presence of aortic sclerosis. Periaortic adipose tissue volume was calculated on a computer assisted work station (Leonardo Workstation, Siemens, Erlangen, Germany) by an experienced radiologist. Patient group (61.63 ± 8.55 years and 50% male) and the control group (61.45 ± 5.68 years, 50% male) each consisted 40 participants. Patient group had significantly higher BUN (42.50 (15.00−211.00) vs. 34.00 (12.00−107.00) mg/dL, p = 0.003), uric acid (5.40 (3.40−14.70) vs. 4.30 (2.30−6.70) ng/mL, p = 0.005) and LDL-C levels (121.50 (60.00−215.00) vs. 86.50 (49.00−209.00) mg/dL, p = 0.001) when compared to control group. Patient group had also significantly higher periaortic adipose tissue volume (32.45 (11.70−51.23) vs. 16.00 (6.29−32.96) ml, p < 0.001). Multivariate regression analysis revealed that periaortic adipose tissue volume was independently associated with the presence of aortic sclerosis (OR 0.241, 95% CI 0.143-0.946, p = 0.001).In this study, we demonstrated for the first time that periaortic adipose tissue volume was independently associated with the presence of sclerotic changes in the adjacent aortic valve.

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Association of serum uric acid levels with SYNTAX score II and long term mortality in the patients with stable angina pectoris who undergo percutaneous coronary interventions due to multivessel and/or unprotected left main disease

Cited by 13 publications

References 36 publications

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

The Potential of Prognostic Biomarkers of Uric Acid Levels in Coronary Heart Disease Among Aged Population: A Scoping Systematic Review of the Latest Cohort Evidence

Periaortic adipose tissue volume is associated with sclerotic changes in the adjacent aortic valve

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