Association of Serum Uric Acid Concentration and Its Change with Cardiovascular Death and All-Cause Mortality

Dong, Ze-Xuan; Tian, Ming; Li, Hua; Wu, Yang; Du, Xian; Dong, Jing; Xiao, Huihui; Dong, Lei; Song, Xiaohong

doi:10.1155/2020/7646384

Cited by 12 publications

(8 citation statements)

References 37 publications

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“…Previous studies report that low and high UA levels are correlated with increased mortality with approximately 1.5~5.0 times higher risk. Notably, 1 mg/dL UA levels increase is related to 3 times higher risk, and a U-shaped association occurs between SUA levels and adverse health outcomes ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes

et al. 2021

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IntroductionThe current study sought to explore the effect of baseline serum uric acid (SUA) on the risk of all-cause mortality among Chinese adults aged 45~75 years and to determine its interaction relationship with diabetes.MethodsThe study was designed as a community-based cohort of 4467 adults aged between 45~75 years included in a 6-years follow-up period from 2009 to 2015 years by the China Health and Nutrition Survey (CHNS). Baseline SUA levels were grouped into quartiles and its association on all-cause mortality was explored using multivariate Cox proportional hazards models. Stratified analyses were performed to explore the associations of SUA quartiles with all-cause mortality among diabetic and non-diabetic individuals.ResultsA total of 141 deaths (5.3 per 1000 person-years) were recorded During a follow-up of 26431 person-years. Out of the 141 deaths, 28 deaths (10.1 per 1000 person-years) were reported in the diabetic groups and 113 deaths (4.8 per 1000 person-years) were recorded in the non-diabetic group. An increased risk of all-cause mortality was observed for participants in the first and fourth quartiles compared with the second SUA quartile, (Q1 SUA: aHR=2.1, 95% CI 1.1~4.1; Q4 SUA: aHR=2.1, 95% CI 1.1~4.0). Stratification of participants by diabetes status showed a U-shaped association for non-diabetic individuals. Whereas, declined eGFR, rather than SUA, was an independent risk factor for all-cause mortality in diabetic individuals (aHR=0.7, 95% CI 0.6~1.0).ConclusionOur study proved that the prognostic role of SUA for predicting all-cause death might be regulated by diabetes. Both low and high SUA levels were associated with increased mortality, supporting a U-shaped association only in non-diabetic individuals. Whereas, renal dysfunction rather than SUA was an independent risk factor for all-cause mortality. Further studies should be conducted to determine the SUA levels at which intervention should be conducted and explore target follow-up strategies to prevent progression leading to poor prognosis.

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Section: Introductionmentioning

confidence: 99%

Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes

et al. 2021

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“…Gerber et al (15) reported that the development of cardiovascular events was higher in those with low uric acid levels. Li et al (24) and Dong et al (25) reported in their study that hemodialysis patients with low uric acid levels were associated with high risk for cardiovascular mortality and all-cause mortality. Aker Karagöz et al (26) reported that there was no relationship between uric acid level and the development of CVD in hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

Evre 3-5 Kronik Böbrek Hastalarında Serum Ürik Asit Seviyesi ve Kardiyovasküler Hastalık Gelişim Riski

Karakose

2020

Düzce Tıp Fakültesi Dergisi

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Aim:The patients with chronic kidney disease (CKD) have higher risk of cardiovascular disease (CVD) than the general population and this risk increases in advanced CKD stages. The data about the association between CVD and uric acid level in stage 3-5 CKD patients are limited in the literature. The aim of this study is to investigate whether uric acid levels are associated with cardiovascular events and mortality in the CKD patients. Material and Methods: Patients who were followed up with the diagnosis of stage 3-5 CKD between June 2014 and December 2019 were evaluated retrospectively. A hundred stage 3-5 CKD cases above the age of eighteen were included in the study. The patients were divided into two groups according to average serum uric acid levels; <7 mg/dL and ≥7 mg/dL. Any confirmed diagnosis of stroke, myocardial infarction, coronary heart disease or heart failure was accepted positive for the history of CVD. Results: Cardiovascular event development was observed in 15 patients and mortality in 1 patient. CVD were seen in 10 (21.3%) patients in group 1 while 5 (9.4%) patients in group 2. Although the cardiovascular events were seen more in the group 1, this difference was not statistically significant (p=0.098). Conclusion:Although CVD is seen higher in the low uric acid (<7 mg/dL) group, no significant association was found between serum uric acid level and development of CVD in stage 3-5 CKD patients, in this study. Prospective studies with larger sample sizes may provide better evidence regarding possible relationship.

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“…Indices of visit-to-visit SUA variability include the coefficient of variation (CV), SD, average real variability (ARV), and variability independent of the mean (VIM). The CV was calculated as (SD/mean) × 100% [24]. The ARV calculated as the average absolute difference between successive measurements [25].…”

Section: Measurement Of Sua Change and Variabilitymentioning

confidence: 99%

Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population

et al. 2021

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Background Evidence on longitudinal variability of serum uric acid (SUA) and risk of all-cause mortality in the general population is limited, as many prior studies focused on a single measurement of SUA. Methods A total of 53,956 participants in the Kailuan study who underwent three health examinations during 2006 to 2010 were enrolled. Variability of SUA was measured using the coefficient of variation (primary index), standard deviation, average real variability, and variability independent of the mean. Cox proportional hazard regressions were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the association of variability of SUA with subsequent risk of all-cause mortality, considering its magnitude and the direction and across different baseline SUA categories. Results Over a median follow-up of 7.04 years, 2728 participants died. The highest variability of SUA was associated with an increased risk of all-cause mortality, the HR was 1.33 (95% CI, 1.20–1.49) compared with the lowest variability. In this group, both a large fall (HR, 1.28; 95% CI, 1.14–1.44) and rise (HR, 1.18; 95% 1.05–1.32) in SUA were related to risk of all-cause mortality. These associations were similar across different baseline SUA categories. Consistent results were observed in alternative measures of SUA variability. Moreover, individuals with higher variability in SUA were more related to common risk factors than those with stable SUA. Conclusions Higher variability in SUA was independently associated with the risk of all-cause mortality irrespective of baseline SUA and direction of variability in the general population.

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Association of Serum Uric Acid Concentration and Its Change with Cardiovascular Death and All-Cause Mortality

Cited by 12 publications

References 37 publications

Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes

Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes

Evre 3-5 Kronik Böbrek Hastalarında Serum Ürik Asit Seviyesi ve Kardiyovasküler Hastalık Gelişim Riski

Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population

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