Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome

Abbasnezhad, Amir; Amani, Reza; Hasanvand, Amin; Rad, Esmaeil Yousefi; Alipour, Meysam; Saboori, Somayeh; Choghakhori, Razieh

doi:10.1080/07315724.2018.1510349

Cited by 21 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 Given that, sex and dietary intake are considered confounding factors in QOL. 36,37 Limiting our sample to women and records of dietary intake are a couple of the strengths of our study.…”

Section: Discussionmentioning

confidence: 99%

<p>The Effect of CoQ10 Supplementation on Quality of Life in Women with Breast Cancer Undergoing Tamoxifen Therapy: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial</p>

Hosseini¹,

Zahrooni²,

Ahmadzadeh³

et al. 2020

PRBM

View full text Add to dashboard Cite

Background: Survival rates among breast cancer patients and the number of patients living with treatment side effects have improved, leading to increased focus on quality of life (QOL). The objective of this study was to determine the efficacy of CoQ 10 on QOL scores among breast cancer patients in Iranian undergoing tamoxifen therapy. Methods: Thirty breast cancer patients were randomized into two groups. The first group received 100 mg CoQ 10 , and the second group took fplacebo once a day for 8 weeks. QOL was evaluated by a standard QOL questionnaire and a specific questionnaire on QOL of breast cancer patients at baseline and the end of the study. Also, physical activity of patients was assessed with the IPAQ questionnaire and dietary intake determined by a 3-day dietary record. Results: The data of 30 subjects were analyzed. According to QOL C30 data, CoQ 10 led to a significant increase in physical functioning (P=0.029), emotional functioning (P=0.031), and cognitive functioning (P=0.023) compared to placebo. Symptom scales revealed a notable reduction in appetite loss in the first group (P=0.01). Global health status showed no significant changes in either study arm. On the QOL BR23, progress in functions and decline in symptoms were not statistically significant. Arm symptoms showed significant reduction (P=0.022) in patients that received placebo. Conclusion: This trial indicates that CoQ 10 supplementation has effects in ameliorating some dimensions of QOL in breast cancer patients. To generalize the results, larger and longer intervention studies are needed. Clinical Trial Registration: IRCT2015042021874N1.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>The Effect of CoQ10 Supplementation on Quality of Life in Women with Breast Cancer Undergoing Tamoxifen Therapy: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial</p>

Hosseini¹,

Zahrooni²,

Ahmadzadeh³

et al. 2020

PRBM

View full text Add to dashboard Cite

show abstract

“…Besides, a relevant experiment was performed by an Iranian research team, where soy isoflavones, vitamin D and placebo were administered in all different combinations to IBS adults and amelioration of severity scores was recorded [18]. In another study [21], 90 IBS patients and the same number of healthy controls were recruited. The IBS group exhibited enhanced incidence of VDD, more severe clinical symptoms, and raised IBS scores.…”

Section: Discussionmentioning

confidence: 99%

“…Recent evidence supports the concept that functional AP, for instance, irritable bowel syndrome (IBS), might be attributed to vitamin D deficiency (VDD), particularly when there is no anatomical–organic correlation or other explanatory pathology [16,17,18,19,20]; VDD is associated with more severe AP, increased scores for the severity of IBS symptoms, and lower quality of life in IBS patients [21]. Moreover, the specific religious or stylistic habits of Muslim patients [22] as well as patients of African [23,24] and middle East origin [25,26] may have an impact on the exposure of skin to the sun and may explain why these patients have a well-documented predisposition to developing VDD [22,23,24,25].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency and Unclear Abdominal Pain in Patients from Low- and Middle-Income Countries

Doulberis

Papaefthymiou

Kountouras

et al. 2019

IJERPH

View full text Add to dashboard Cite

Background: Abdominal pain is one of the commonest symptoms in emergency departments (EDs). Diagnosis demands full attention and critical thinking, since many diseases manifest atypically and the consequences of overlooking the symptoms may be disastrous. Despite intensive diagnostic procedures, some cases remain elusive and unclear abdominal pain (UAP) is not infrequent. Emerging evidence supports the hypothesis that functional pain might be attributed to vitamin D deficiency (VDD). People with darker or covered skin are predisposed to developing VDD. Patients in Switzerland stemming from low- and middle-income countries (LMIC) are such a population. Aim: To identify cases with UAP in LMIC patients and to compare vitamin D status with a control group. Methods: A retrospective single-center case-control study was carried out from 1 January 2013 to 31 August 2016 in all adult patients (more than 16 years old) stemming from LMIC and presenting at the university ED of Bern with abdominal pain. Vitamin D status was retrieved from these cases when available. The control group consisted of patients without abdominal pain or metabolic diseases and was matched (1:1) to the cases for age, gender, body mass index, geographic distribution, and season of vitamin D estimation. Results: A total of 10,308 cases from LMIC were reported to the ED. In total, 223 cases were identified with UAP. The status of vitamin D was available for 27 patients; 27 matched individuals were subsequently retrieved for the control group. Women made up 56.7% of the UAP group and 43.3% of the control group. The most common origin of the LMIC subjects was southern Europe (20.4%), followed by southern Asia (16.7%) and Eastern Europe (13%). Fourteen UAP patients exhibited severe VDD (<25 nmol/L) versus one in the control group (p = 0.001). The difference remained significant if the patients were identified as having VDD (<50 nmol/L) or not (p = 0.024). Comparison of the means indicated that the UAP group had lower vitamin D levels than the control group (41.3 vs. 53.7 nmol/L, respectively), but this difference was marginal (p = 0.060) and not statistically significant. After adjustment for potential confounders, including gender, mean vitamin D levels remained non-significantly different between groups. In the sub-group analysis, vitamin D levels were lower in women than in men (p = 0.037), compared to the respective controls. Conclusion: This study showed for the first time that patients from LMIC who presented to ED with UAP displayed VDD. Validation from larger studies is warranted to evaluate the linkage of VDD with UAP.

show abstract

“…40 Many studies in various study population such as cancer, irritable bowel syndrome, diabetic neuropathy also demonstrated that vit D deficiency was associated with a higher severity of clinical symptoms and lower QoL. [41][42][43] Vitamin D is one of the most cost-effective micronutrient supplements, that leads to improving overall human health. 44 However, there have been controversy about the identification of the vit D deficiency and sufficiency, appropriate treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Bolus Vitamin D Supplementation

Bozkurt¹,

Alkan²,

Ural³

et al. 2019

Ankara Medical Journal

View full text Add to dashboard Cite

Objectives: Vitamin D plays an important role in musculoskeletal and nervous system health. Although, the prevalence of vitamin D deficiency is fairly high and it may lead to bone abnormalities and muscle weakness, it is a preventable condition. The aim of this prospective study was to assess the effects of vitamin D supplementation on balance, mobility, grip strength, fatigue, depression and quality of life. Materials and Methods: Between October 1, 2015 and December 31, 2015, a total of 92 patients with vitamin D insufficiency/deficiency were included in the study. Demographic characteristics of age, gender, height, weight, serum 25-hydroxyvitamin [25-(OH)D], parathyroid hormone, alkaline phosphatase (ALP), calcium, and phosphorus levels were recorded. The primary outcome was assessed the [25-(OH) D] levels at 1 month and 3 month post-treatment. The secondary outcomes were the efficacy of vitamin D administration on fatigue, mobility, balance, depression, quality of life (QoL), muscle strength using The Multidimensional Assessment of Fatigue Scale (MAF), Timed Up and Go Test (TUG), Single leg stance test (SLS), Beck Depression Inventory (BDI), The Nottingham Health Profile(NHP), hand dynamometer, respectively at all visits. Results: After the 1 month, the vitamin D supplementation had significantly improved muscle strength, balance ability, mobility, QoL, depression, and fatigue symptoms. The levels of [25-(OH) D] significant decreased after 3 months. Conclusion:Supplemental vitamin D consistently demonstrated beneficial effects on muscle strength, mobility, balance control, depression, fatigue and QoL. The 300,000 bolus of vitamin D was well-tolerated and safe in adult population. We would recommend evaluating vitamin D status once in three months.

show abstract

Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome

Cited by 21 publications

References 35 publications

<p>The Effect of CoQ10 Supplementation on Quality of Life in Women with Breast Cancer Undergoing Tamoxifen Therapy: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial</p>

<p>The Effect of CoQ10 Supplementation on Quality of Life in Women with Breast Cancer Undergoing Tamoxifen Therapy: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial</p>

Vitamin D Deficiency and Unclear Abdominal Pain in Patients from Low- and Middle-Income Countries

The Effect of Bolus Vitamin D Supplementation

Contact Info

Product

Resources

About