Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of Allergic Rhinitis

Abstract

Objective The aim of this study was to determine the association of serum vitamin D and immunoglobulin E (IgE) levels with the severity of allergic rhinitis (AR). Methods This case-control study was conducted at Mayo Hospital, Lahore, from June to September 2020 after obtaining ethical approval. Patients of AR were included and divided with the help of allergic rhinitis and its impact on asthma (ARIA) classification, into group A (cases), patients presenting with moderate to severe symptoms, and into group B (control), patients with mild symptoms, after treatment of AR. The mean difference between serum IgE and serum Vitamin D levels of both groups were compared by t-test. Association was determined by logistic regression and odds ratio. Results A total of 224 patients were included in the study, 112 patients in group A and 112 patients in group B. There were 106 (47.3%) female and 118 (52.7%) male. The mean age of patients in group A was 26.78± 8.92 years and in group B, it was 25.72±8.12 years. Mean serum vitamin D levels in group A were 16.24±6.7 ng/ml and in group B 26.92±35 ng/ml (p=0.0001). Mean serum IgE levels in group A were 383.69±154.86 IU/ml and in group B, they were 373.03±106.83 IU/ml (p=0.0001). Vitamin D deficient patients were 24 times more likely to develop moderate to severe AR disease. Conclusion This study showed that in moderate-severe AR, IgE levels are raised statistically as compared to mild AR and the deficiency of Vitamin D is associated with increasing severity of allergic rhinitis symptoms.

Medication Adherence to Intranasal Corticosteroids in Allergic Rhinitis Patients with Comorbid Medical Conditions

“…Elevated total serum IgE was a common finding in allergic conditions, which can help clinicians to verify the diagnosis of bronchial asthma or allergic rhinitis. A higher total serum IgE level is linked with a greater burden of disease exemplified in a study by Nukhbat et al, who found that serum IgE levels were higher in moderate to severe AR compared to the milder form [24]. The majority of our patients had an elevated total serum IgE and it is associated with a significantly higher medication adherence.…”

A Novel Strategy for the Treatment of Allergic Rhinitis: Regulating Treg/Th17 and Th1/Th2 Balance In Vivo by Vitamin D

“…Allergic rhinitis is one of the most common pediatric diseases with high incidence worldwide [17][18][19][20]. In recent years, the incidence of allergic rhinitis and some respiratory diseases has increased significantly with the aggravation of air pollution and environmental deterioration.…”

Association of vitamin D levels and VDR variant (rs2228570) with allergic rhinitis: A meta-analysis and trial sequential analysis

“…Several investigations have been carried out in different populations to explore the possible link between vitamin D and AR; however, the results remained contradictory. Although vitamin D deficiency has been related to susceptibility to AR in a wide range of populations [ [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] ], there are reports highlighting the absence of a link between vitamin D and allergic rhinitis [ 20 , 21 ]. Furthermore, another study in Pakistanis [ 10 ] found that 10% of AR had adequate vitamin D levels compared to 26% of healthy controls, but the difference was not statistically significant.…”