Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults

Miah, Rakib; Fariha, Khandaker Atkia; Sony, Sabrina Amita; Ahmed, Shamim; Hasan, Mahmudul; Mou, Ananya Dutta; Barman, Zitu; Hasan, Akibul; Mohanto, Nayan Chandra; Ali, Nurshad

doi:10.1038/s41598-022-26341-5

Cited by 11 publications

(7 citation statements)

References 52 publications

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“…Potential mechanisms include the influence of sex hormones and genetic differences between the sexes ( 53 , 54 ). Studies have shown a positive and independent correlation between xanthine oxidase (XO) levels and hypertension ( 55 ). XO is a UA-producing enzyme, and estradiol in women can inhibit isolated XO ( 30 ), resulting in a stronger association of SBP with hyperuricemia in girls.…”

Section: Discussionmentioning

confidence: 99%

Combining body mass index and waist height ratio to assess the relationship between obesity and serum uric acid levels in adolescents

et al. 2023

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BackgroundThe study aims to explore the relationship between obesity and serum uric acid in adolescents by combining body mass index and waist height ratio.Methods475 adolescents in our study were classified as normal weight without central obesity (NW), normal weight but central obesity (NWCO), overweight or obesity without central obesity (OB) and overweight or obesity with central obesity (OBCO). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. The dose-response association between obesity indicators and serum uric acid were explored by restricted cubic spline model.ResultsThe highest serum uric acid level and the OR for hyperuricemia were found in the OBCO group, regardless of sex. After controlling for waist height ratio, the risk of hyperuricemia increased with increasing body mass index in boys and girls. The restricted cubic spline model showed that boys had higher ORs for hyperuricemia at the 25th and 75th percentiles of body mass index than for waist height ratio and girls had a higher OR for hyperuricemia than waist height ratio at the 25th percentile of body mass index.ConclusionsHyperuricemia in adolescence was not only associated with the overweight or obesity in BMI, but with the combination of overweight or obesity in BMI and central obesity in WHtR. However, in boys and girls, the increased risk of hyperuricemia associated with elevated body mass index was significantly better than that of waist height ratio.

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Section: Discussionmentioning

confidence: 99%

Combining body mass index and waist height ratio to assess the relationship between obesity and serum uric acid levels in adolescents

et al. 2023

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“…A multitude of epidemiological and experimental studies have established a connection between HUA and HTN. These studies suggest that HUA plays a signi cant role in the development of HTN, highlighting the frequent coexistence of these two disorders [9]. The prevalence of HUA is notably higher in hypertensive patients compared to the general population, with 35% in men and 43% in women [10], while it is much lower in normotensive individuals.…”

Section: Introductionmentioning

confidence: 88%

The correlation between Framingham risk score and hypertension combined with hyperuricemia in an elderly community-based population--a 7-year cohort follow-up study

Shen,

Li,

et al. 2024

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Background Research has consistently demonstrated a robust association between hypertension (HTN) and hyperuricemia (HUA), indicating a potential synergistic effect on cardiovascular disease (CVD) risk. This study aims to explore the epidemiological characteristics of hypertension combined with hyperuricemia (HTN-HUA) and to identify the risk factors contributing to its incidence. Methods This study was a cohort follow-up, utilizing a community-based cohort consisting of older adults aged 65 years or older. Initially, the study enrolled 3,950 participants in a prospective manner. After the exclusion of cases with missing data, the analysis ultimately included 3,089 participants. We employed the Framingham Risk Score (FRS) formula to estimate the risk of CVD. Survival analysis was conducted to explore the relationship between FRS and CVD death/all-cause mortality. Furthermore, multiple logistic regression models were utilized to assess the association between FRS and HTN-HUA. Results Within the study population, we found that approximately 29.6% of hypertensive patients were also suffering from HUA. We observed that regardless of the presence of HTN or HUA, age, WC, SBP, DBP, Scr, and UA levels were significantly higher in the High-risk group than in the L-M risk group (P < 0.05). The Kaplan-Meier survival analysis, which used CVD death as the endpoint, revealed a significant difference in survival curves between the High-risk and low-intermediate (L-M) risk groups among relatively healthy individuals (P < 0.01). Furthermore, following adjustments for confounding variables, logistic regression analysis revealed that the risk of HTN-HUA in the High-risk group was 1.485 times greater than in the L-M risk group (OR = 1.485, 95% CI: 1.092–2.021). Conclusion In a community-based elderly population in China, the prevalence of HTN-HUA was found to be 17.5%. The FRS effectively predicted a 10-year cardiovascular risk in a relatively healthy population. Additionally, waist circumference (WC) and body mass index (BMI) were identified as significant risk factors for the development of HTN-HUA.

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“…The blood samples were centrifuged by an ultracentrifuge machine (Sorvall ST 8R Centrifuge, Thermo Scientific, Germany) and serum samples were stored at − 20 °C at the Departmental laboratory until biomarker analysis. Serum level of uric acid (SUA), fasting blood glucose (FBG), serum creatinine (SCr), serum albumin (SA), serum urea (SU), serum total protein (STP), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were measured by colorimetric method using commercially available kits (Human Diagnostic, Germany) with the biochemistry analyzer (Humalyzer 3000, USA) [ 32 – 34 ]. The accuracy of the measurements was maintained with regular standard calibration.…”

Section: Methodsmentioning

confidence: 99%

Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

et al. 2023

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Background and aims Chronic kidney disease (CKD) is a public health concern worldwide and has been recognized as a significant risk factor for cardiovascular disease. The elevated level of uric acid (hyperuricemia) has been suggested to be associated with obesity, hypertension, cardiovascular disease and diabetes. However, there is limited information on the relationship between hyperuricemia and CKD. Therefore, this study aimed to estimate the prevalence of CKD and assess its relationship with hyperuricemia in Bangladeshi adults. Methods In this study, blood samples were collected from 545 participants (398 males and 147 females) aged ≥ 18 years. Biochemical parameters such as serum uric acid (SUA), lipid profile markers, glucose, creatinine and urea were measured by colorimetric methods. The estimated glomerular filtration rate (eGFR) and CKD were determined based on serum creatinine levels with existed formula. Multivariate logistic regression analysis was performed to evaluate the association between SUA and CKD. Results The overall prevalence of CKD was 5.9% with 6.1% in males and 5.2% in females. Hyperuricemia was prevalent in 18.7% of participants with 23.2% in males and 14.6% in females. An increasing trend of CKD prevalence was observed with increasing age in the groups. The mean eGFR level was significantly lower in male (95.1 ± 31.8 ml/min/1.73m2) than in female (109.3 ± 77.4 ml/min/1.73m2) subjects (p < 0.01). The mean level of SUA was significantly higher (p < 0.01) in participants having CKD (7.1 ± 1.9 mg/dL) than in participants without CKD (5.7 ± 1.6 mg/dL). A decreasing trend for eGFR concentration and an increasing trend for CKD prevalence was observed across the SUA quartiles (p < 0.001). In regression analysis, a significant positive association was found between hyperuricemia and CKD. Conclusion This study showed an independent association between hyperuricemia and CKD in Bangladeshi adults. Further mechanistic studies are needed to explore the potential link between hyperuricemia and CKD.

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Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults

Cited by 11 publications

References 52 publications

Combining body mass index and waist height ratio to assess the relationship between obesity and serum uric acid levels in adolescents

Combining body mass index and waist height ratio to assess the relationship between obesity and serum uric acid levels in adolescents

The correlation between Framingham risk score and hypertension combined with hyperuricemia in an elderly community-based population--a 7-year cohort follow-up study

Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

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