Association of Sex Hormones and Fat Distribution in Men with Different Obese and Metabolic Statuses

YH, Zhou; Guo, Yang; Wang, F; CL, Zhou; CY, Tang; HN, Tang; DW, Yan; HD, Zhou

doi:10.2147/ijgm.s351282

Cited by 7 publications

(2 citation statements)

References 38 publications

(72 reference statements)

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“…45 Besides differences in lifestyle, such as smoking, the main determinant might be sex hormones. 46,47 The association of sex hormones with fat volume and distribution needs to be verified in the future.…”

Section: Discussionmentioning

confidence: 99%

Fat distribution measurements by chemical shift‐encoded transition region extraction predict the risk of hyperglycaemia, dyslipidaemia and metabolic syndrome in mice

Lin

Cheng

et al. 2023

NMR in Biomedicine

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Metabolically healthy or unhealthy obesity is closely related to metabolic syndrome (MetS). To validate a more accurate diagnostic method for obesity that reflects the risk of metabolic disorders in a pre‐clinical mouse model, C57BL/6J mice were fed high‐sucrose–high‐fat and chow diets for 12 weeks to induce obesity. MRI was performed and analysed by chemical shift‐encoded fat–water separation based on the transition region extraction method. Abdominal fat was divided into upper and lower abdominal regions at the horizontal lower border of the liver. Blood samples were collected, and the glucose level, lipid profile, liver function, HbA1c and insulin were tested. k‐means clustering and stepwise logistic regression were applied to validate the diagnosis of hyperglycaemia, dyslipidaemia and MetS, and to ascertain the predictive effect of MRI‐derived parameters to the metabolic disorders. Pearson or Spearman correlation was used to assess the relationship between MRI‐derived parameters and metabolic traits. The receiver‐operating characteristic curve was used to evaluate the diagnostic effect of each logistic regression model. A two‐sided p value less than 0.05 was considered to indicate statistical significance for all tests. We made the precise diagnosis of obesity, dyslipidaemia, hyperglycaemia and MetS in mice. In all, 14 mice could be diagnosed as having MetS, and the levels of body weight, HbA1c, triglyceride, total cholesterol and low‐density lipoprotein cholesterol were significantly higher than in the normal group. Upper abdominal fat better predicted dyslipidaemia (odds ratio, OR = 2.673; area under the receiver‐operating characteristic curve, AUCROC = 0.9153) and hyperglycaemia (OR = 2.456; AUCROC = 0.9454), and the abdominal visceral adipose tissue (VAT) was better for predicting MetS risk (OR = 1.187; AUCROC = 0.9619). We identified the predictive effect of fat volume and distribution in dyslipidaemia, hyperglycaemia and MetS. The upper abdominal fat played a better predictive role for the risk of dyslipidaemia and hyperglycaemia, and the abdominal VAT played a better predictive role for the risk of MetS.

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Section: Discussionmentioning

confidence: 99%

Fat distribution measurements by chemical shift‐encoded transition region extraction predict the risk of hyperglycaemia, dyslipidaemia and metabolic syndrome in mice

Lin

Cheng

et al. 2023

NMR in Biomedicine

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“…The accompanied increase in circulating free fatty acids may result in the lipid infiltration of the liver, pancreas, and skeletal muscles, leading to the deterioration of their function. Obesity is also associated with disturbances in sex steroid synthesis and signaling, negatively affecting fertility [ 16 , 17 ]. On the other hand, owing to the well-described effects of androgens and estrogens on muscle mass, structure, and function, the impaired sex steroid balance in obesity may result in the deterioration of muscle health [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction

Sheptulina,

Antyukh,

Kiselev

et al. 2023

Life

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Increasing evidence suggests that skeletal muscles may play a role in the pathogenesis of obesity and associated conditions due to their impact on insulin resistance and systemic inflammation. Skeletal muscles, as well as adipose tissue, are largely recognized as endocrine organs, producing biologically active substances, such as myokines and adipokines. They may have either beneficial or harmful effects on the organism and its functions, acting through the endocrine, paracrine, and autocrine pathways. Moreover, the collocation of adipose tissue and skeletal muscles, i.e., the amount of intramuscular, intermuscular, and visceral adipose depots, may be of major importance for metabolic health. Traditionally, the generalized and progressive loss of skeletal muscle mass and strength or physical function, named sarcopenia, has been thought to be associated with age. That is why most recently published papers are focused on the investigation of the effect of obesity on skeletal muscle function in older adults. However, accumulated data indicate that sarcopenia may arise in individuals with obesity at any age, so it seems important to clarify the possible mechanisms linking obesity and skeletal muscle dysfunction regardless of age. Since steroids, namely, glucocorticoids (GCs) and sex steroids, have a major impact on the amount and function of both adipose tissue and skeletal muscles, and are involved in the pathogenesis of obesity, in this review, we will also discuss the role of steroids in the interaction of these two metabolically active tissues in the course of obesity.

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Association between visceral adipose tissue and total testosterone among the United States male adults: a cross-sectional study

Gu,

Zhu,

Gao

et al. 2024

Int J Impot Res

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Association of Sex Hormones and Fat Distribution in Men with Different Obese and Metabolic Statuses

Cited by 7 publications

References 38 publications

Fat distribution measurements by chemical shift‐encoded transition region extraction predict the risk of hyperglycaemia, dyslipidaemia and metabolic syndrome in mice

Fat distribution measurements by chemical shift‐encoded transition region extraction predict the risk of hyperglycaemia, dyslipidaemia and metabolic syndrome in mice

Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction

Association between visceral adipose tissue and total testosterone among the United States male adults: a cross-sectional study

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