Association of sex hormones with physical, laboratory, and imaging markers of anthropometry in men and women from the general population

Seyfart, Tom; Friedrich, Nele; Kische, Hanna; Bülow, Robin; Wallaschofski, Henri; Völzke, Henry; Nauck, Matthias; Keevil, Brian; Häring, R.

doi:10.1371/journal.pone.0189042

Cited by 21 publications

(26 citation statements)

References 31 publications

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“…Similar research was conducted by Seyfart T et al [ 30 ], who evaluated the association between sex hormones and anthropometry in a large population-based cohort, and found that testosterone levels were inversely associated with all relevant anthropometric parameters in men. On the other hand, a significant positive relationship between obesity and DHEA-S was demonstrated by Turkish researchers [ 31 ]. Their study, however, involved only 37 men.…”

Section: Discussionmentioning

confidence: 99%

Cross-Sectional Inverse Associations of Obesity and Fat Accumulation Indicators with Testosterone in Non-Diabetic Aging Men

Rotter

Rył

Grzesiak

et al. 2018

IJERPH

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Introduction/Objective: The aim of the study was to show which of the adipose tissue accumulation indicators correlate with testosterone disorders in non-diabetic aging men. Material and methods: 455 non diabetic men, recruited at primary care facilities, aged 50–75 participated in the study. The participants underwent anthropometric measurement and ELISA determination of total testosterone (TT), estradiol (E2), dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding protein (SHBG), and the determination of fasting glucose (FPG), high-density lipids cholesterol (HDL-Ch), and triacylglycerols (TAG) in serum. The following indicators were calculated: body mass index (BMI), waist-to-hip ratio (WHR), lipid accumulation product (LAP), and visceral adiposity index (VAI). Results: Men with testosterone deficiency syndrome (TDS) differed in each of the assessed obesity indices from those without TDS. All of the studied parameters correlated significantly negatively with TT concentration in blood serum, with VAI being the strongest predictor of TDS. It was shown that the threshold value at which the risk of TDS increased was 28.41 kg/m2 for BMI, 1.58 for VAI, 104 cm for WC, and 37.01 for LAP. Conclusions: Indicators of fat accumulation that take into account biochemical parameters in assessing lipid metabolism are better markers of actual body fat deposition than indicators based solely on anthropometric measurements. Among them, VAI seems the most suitable biomarker of TDS in non-diabetic aging men.

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Section: Discussionmentioning

confidence: 99%

Cross-Sectional Inverse Associations of Obesity and Fat Accumulation Indicators with Testosterone in Non-Diabetic Aging Men

Rotter

Rył

Grzesiak

et al. 2018

IJERPH

View full text Add to dashboard Cite

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“…In opposition to these results a RCT (43) and two observational studies examining changes in body weight in male patients with hypogonadism before and after initiation of testosterone treatment found a mean decrease in BMI of approximately four BMI points (44, 45, 46). For women obesity has been associated with higher levels of estrogens (41, 47) but to our knowledge no studies looking at weight change related to treatment of secondary hypogonadism in women has been published.…”

Section: Discussionmentioning

confidence: 99%

Metabolic effects of dopamine agonists in patients with prolactinomas: a systematic review and meta-analysis

Byberg

Futtrup

Andreassen

et al. 2019

Endocrine Connections

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ObjectivesRecent large cohort studies suggest an association between high plasma prolactin and cardiovascular mortality. The objective of this systematic review was to systematically assess the effect of reducing prolactin with dopamine agonist on established cardiovascular risk factors in patients with prolactinomas.DesignBibliographical search was done until February 2019 searching the following databases: PubMed, EMBASE, WHO and LILAC. Eligible studies had to include participants with verified prolactinomas where metabolic variables were assessed before and after at least 2 weeks treatment with dopamine agonists.MethodsBaseline data and outcomes were independently collected by two investigators. The study was registered with PROSPERO (registration number CRD42016046525).ResultsFourteen observational studies enrolling 387 participants were included. The pooled standardized mean difference of the primary outcome revealed a reduction of BMI and weight of −0.21 (95% CI −0.37 to −0.05; P = 0.01; I2 = 71%), after treatment. Subgroup analysis suggested that the reduction of weight was primarily driven by studies with high prolactin levels at baseline (P = 0.04). Secondary outcomes suggested a small decrease in waist circumference, a small-to-moderate decrease in triglycerides, fasting glucose levels, HOMA-IR, HbA1c and hsCRP, and a moderate decrease in LDL, total cholesterol and insulin.ConclusionThis systematic review suggests a reduction of weight as well as an improved lipid profile and glucose tolerance after treatment with dopamine agonist in patients with prolactinomas. These data are based on low-quality evidence.

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“…Sex steroid hormones are likely involved in the sex-related serum leptin differences observed in the current study [ 38 – 40 ]. In murine adipocytes, leptin production and secretion were reduced by dihydrotestosterone but increased by 17β-estradiol.…”

Section: Discussionmentioning

confidence: 99%

“…[ 39 ]. Increased leptin production per unit mass of adipose tissue induced by sex steroids may explain the higher serum leptin levels in women [ 38 – 40 ]. Conversely, sex steroids do not appear to influence resting gas exchange [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Dual effects of leptin in perioperative gas exchange of morbidly obese patients

et al. 2018

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Leptin has shown positive effects on respiratory function in experimental settings. The role of leptin on perioperative respiratory function in morbidly obese patients has not been established. We performed a retrospective analysis of morbidly obese patients undergoing laparoscopic sleeve gastrectomy. Fasting serum leptin and interleukin (IL)-6 were measured preoperatively, and arterial blood gases were obtained pre- and postoperatively. Outcome variables were arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and differences in PaO2 and PaCO2 between pre- and postoperative values (ΔPaO2, ΔPaCO2; postoperative minus preoperative). Patients with lower (<40 μg/L) and higher (≥40 μg/L) leptin levels were compared. Bravais-Pearson’s correlation, multiple linear regression, and logistic regression analysis were performed. A total of 112 morbidly obese patients were included. Serum leptin was significantly higher in females than in males (42.86±12.89 vs. 30.67±13.39 μg/L, p<0.0001). Leptin was positively correlated with body mass index (r = 0.238; p = 0.011), IL-6 (r = 0.473; p<0.0001), and ΔPaO2 (r = 0.312; p = 0.0008). Leptin was negatively correlated with preoperative PaO2 (r = -0.199; p = 0.035). Preoperative PaO2 was lower, ΔPaCO2 was smaller, and ΔPaO2 was greater in the high leptin group than in the low leptin group. In multiple regression analysis, leptin was negatively associated with preoperative PaO2 (estimate coefficient = -0.147; p = 0.023). In logistic regression analysis, leptin was associated with improved ΔPaO2 (odds ratio [OR] = 1.104; p = 0.0138) and ΔPaCO2 (OR = 0.968; p = 0.0334). Leptin appears to have dual effects related to perioperative gas exchange in obese patients undergoing bariatric surgery. It is associated with worse preoperative oxygenation but improved respiratory function after surgery.

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Association of sex hormones with physical, laboratory, and imaging markers of anthropometry in men and women from the general population

Cited by 21 publications

References 31 publications

Cross-Sectional Inverse Associations of Obesity and Fat Accumulation Indicators with Testosterone in Non-Diabetic Aging Men

Cross-Sectional Inverse Associations of Obesity and Fat Accumulation Indicators with Testosterone in Non-Diabetic Aging Men

Metabolic effects of dopamine agonists in patients with prolactinomas: a systematic review and meta-analysis

Dual effects of leptin in perioperative gas exchange of morbidly obese patients

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