Association of Sex or Race With the Effect of Weight Loss on Physical Function

Beavers, Kristen M.; Neiberg, Rebecca H.; Kritchevsky, Stephen B.; Nicklas, Barbara J.; Kitzman, Dalane W.; Messier, Stephen P.; Rejeski, W. Jack; Ard, Jamy D.; Beavers, Daniel P.

doi:10.1001/jamanetworkopen.2020.14631

Cited by 12 publications

(7 citation statements)

References 46 publications

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“…In contrast, the risk estimates of functional disability were reduced in participants with regression of depression-obesity status from baseline to follow-up. The findings were in line with previously published literatures showing that treatment of depression or weight loss could restore functional ability [ 52 , 53 ]. Furthermore, a randomized controlled trial has demonstrated that compared to usual care, an integrated collaborative care intervention for individuals with comorbid depression and obesity could improve functional outcome measured by the Sheehan Disability Scale at 6 months, but not at 12 months [ 54 ].…”

Section: Discussionsupporting

confidence: 92%

Comorbid depression and obesity, and its transition on the risk of functional disability among middle-aged and older Chinese: a cohort study

et al. 2022

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Background Evidence has indicated that depression and obesity were associated with functional disability, independently. However, little is known about the detrimental impact of comorbid depression and obesity, as well as its transition on functional disability. This study investigated the association of baseline depression-obesity status and its dynamic change with incident functional disability among middle-aged and older Chinese. Methods This cohort study included 5507 participants aged ≥45 years from the 2011 and 2015 waves of China Health and Retirement Longitudinal Study. Depression was defined with a score ≥ 10 using the 10-item Centre for Epidemiologic Studies Depression Scale. Obesity was defined as body mass index ≥28 kg/m2. Participants were cross-classified by depression and obesity status at baseline, and its change during follow-up. Logistic regression models were constructed to evaluate the association of baseline depression-obesity status and its transition with incident functional disability defined by the Katz index of activities of daily living scale. Results Over four-year follow-up, 510 (9.3%) participants developed functional disability. Individuals with baseline comorbid depression and obesity had the highest risk of functional disability (OR = 2.84, 95% CI: 1.95–4.15) than non-depressive participants without obesity, or those with depression or obesity alone. When investigating the dynamic changes of depression-obesity status on functional disability incidence, those with stable comorbidity throughout two surveys had the greatest risk of functional disability (OR = 4.06, 95% CI: 2.11–7.80). Progression of depression-obesity status was associated with increased risk of functional disability, while regression from baseline to follow-up was linked to attenuated risk estimates. Conclusions Among middle-aged and older Chinese adults, the risk of functional disability was exaggerated with comorbid depression and obesity. Our data further suggest that transitions of depression and obesity over time are associated with the risk of developing functional disability.

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Section: Discussionsupporting

confidence: 92%

Comorbid depression and obesity, and its transition on the risk of functional disability among middle-aged and older Chinese: a cohort study

et al. 2022

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“…The effects of CL on adipocytes mirror the effects of exercise, especially regarding exercise-mediated increases in UCP1 [ 39 , 40 ]. Thus, it is interesting to note that there are also sex differences in exercise-mediated fat loss [ 41 , 42 ]. Such differences may be due to differences in ER signaling.…”

Section: Introductionmentioning

confidence: 99%

White Adipose Tissue Depots Respond to Chronic Beta-3 Adrenergic Receptor Activation in a Sexually Dimorphic and Depot Divergent Manner

Queathem

Welly

Clart

et al. 2021

Cells

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Beta-3 adrenergic receptor activation via exercise or CL316,243 (CL) induces white adipose tissue (WAT) browning, improves glucose tolerance, and reduces visceral adiposity. Our aim was to determine if sex or adipose tissue depot differences exist in response to CL. Daily CL injections were administered to diet-induced obese male and female mice for two weeks, creating four groups: male control, male CL, female control, and female CL. These groups were compared to determine the main and interaction effects of sex (S), CL treatment (T), and WAT depot (D). Glucose tolerance, body composition, and energy intake and expenditure were assessed, along with perigonadal (PGAT) and subcutaneous (SQAT) WAT gene and protein expression. CL consistently improved glucose tolerance and body composition. Female PGAT had greater protein expression of the mitochondrial uncoupling protein 1, while UCP1 (S, p < 0.001) was more responsive to CL in increasing UCP1 (S×T, p = 0.011) and the mitochondrial biogenesis induction protein, PPARγ coactivator 1α (PGC1α) (S×T, p = 0.026). Females also displayed greater mitochondrial OXPHOS (S, p < 0.05) and adiponectin protein content (S, p < 0.05). On the other hand, male SQAT was more responsive to CL in increasing protein levels of PGC1α (S×T, p = 0.046) and adiponectin (S, p < 0.05). In both depots and in both sexes, CL significantly increased estrogen receptor beta (ERβ) and glucose-related protein 75 (GRP75) protein content (T, p < 0.05). Thus, CL improves systemic and adipose tissue-specific metabolism in both sexes; however, sex differences exist in the WAT-specific effects of CL. Furthermore, across sexes and depots, CL affects estrogen signaling by upregulating ERβ.

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“…This is unsurprising as hip OA is more common in females than males [ 50 ]. Future clinical trials should consider stratifying by sex to balance the sexes across trial arms [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of exercise and weight management for people with hip osteoarthritis and overweight or obesity: A pilot study

Hall

Spiers

Knox

et al. 2021

Osteoarthritis and Cartilage Open

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Association of Sex or Race With the Effect of Weight Loss on Physical Function

Abstract: This secondary analysis of 8 randomized clinical trials assesses whether stratification by sex and race is associated with meaningful differences in physical function response to weight loss among older adults.

Cited by 12 publications

References 46 publications

Comorbid depression and obesity, and its transition on the risk of functional disability among middle-aged and older Chinese: a cohort study

Comorbid depression and obesity, and its transition on the risk of functional disability among middle-aged and older Chinese: a cohort study

White Adipose Tissue Depots Respond to Chronic Beta-3 Adrenergic Receptor Activation in a Sexually Dimorphic and Depot Divergent Manner

Feasibility of exercise and weight management for people with hip osteoarthritis and overweight or obesity: A pilot study

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