Association of sFlt-1 and C-reactive protein with outcomes in severe preeclampsia

Nóbrega, Leandro; Katz, Leila; Lippo, Luis; Amorim, Melânia Maria Ramos

doi:10.1097/md.0000000000029059

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Predicting adverse pregnancy outcome in expectant mothers is crucial in clinical practice, facilitating the early identification of high-risk patients and the implementation of appropriate interventions [27,28]. This approach not only improves maternal and neonatal health but also optimizes the use of healthcare resources.…”

Section: Discussionmentioning

confidence: 99%

Thyroid-stimulating hormone and total bile acids can predict adverse pregnancy outcome among patients with gestational hypertension

Tian

2024

Am J Transl Res

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Objective: To investigate the correlation between serum thyroid-stimulating hormone (TSH) and total bile acid (TBA) levels in gestational hypertension and their combined predictive value for pregnancy outcome. Methods: A total of 194 patients with gestational hypertension (GH), treated from June 2020 to May 2022, were included in this study. The patients were divided into two subgroups based on pregnancy outcome: an adverse pregnancy outcome group (77 cases) and a normal pregnancy outcome group (117 cases). Additionally, 50 healthy pregnant women undergoing routine prenatal checkups during the same period served as the control group. In this study, serum TBA and TSH levels were measured and compared between the control and GH groups as well as between adverse pregnancy outcome and normal pregnancy outcome groups. The independent risk factors for adverse pregnancy outcome were screened using logistic regression, and their predictive value for pregnancy outcome in patients with GH was analyzed using receiver operating characteristic (ROC) curves. Results: Serum TSH and TBA levels were significantly higher in the GH group compared to the normal group (both P < 0.001). Logistic regression analysis revealed that age, body mass index (BMI), TSH, and TBA were independent risk factors for adverse pregnancy outcome. ROC curve analysis showed that combined TSH and TBA for predicting adverse pregnancy outcome had an Area Under the Curve (AUC) of 0.896, surpassing the AUCs of each individual index (0.843 for TSH and 0.765 for TBA), which indicates a stronger predictive value (P < 0.001). Conclusion: The combined measurement of serum TBA and TSH can serve as a valuable predictive tool for pregnancy outcome in patients with gestational hypertension.

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Section: Discussionmentioning

confidence: 99%

Thyroid-stimulating hormone and total bile acids can predict adverse pregnancy outcome among patients with gestational hypertension

Tian

2024

Am J Transl Res

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“…A meta-analysis highlighted that alterations in the sFlt-1/PLGF ratio are among the earliest markers detectable in PE, possessing a higher negative predictive value for adverse pregnancy outcomes than either PLGF or sFlt-1 levels alone [18]. Furthermore, excessively low sFlt-1/PLGF ratios have been linked to an increased risk of adverse pregnancy outcomes [19,20], and high sFlt-1 levels have been associated with a greater likelihood of preterm labor [21].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Prognostic Value of Serum PLGF, sFlt-1, and sFlt-1/PLGF Ratios in Predicting Adverse Pregnancy Outcomes in Preeclampsia: A Comprehensive Analysis

Liu,

Liang,

et al. 2024

IJCEMR

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Objective: This study investigates the correlation between serum levels of placental growth factor (PLGF), soluble FMS-like tyrosine kinase-1 (sFlt-1), and the sFlt-1/PLGF ratio, and adverse pregnancy outcomes in preeclampsia (PE) patients. Methods: We analyzed data from 1,383 pregnant women diagnosed with preeclampsia at Xi'an People's Hospital (No. 4 Hospital of Xi'an) from July 2022 to June 2023. The participants were categorized into a PE group of 95 individuals, further divided into 53 with mild preeclampsia (mPE) and 42 with severe preeclampsia (sPE), and a control group of 1,288 individuals. The PE group was also subdivided based on pregnancy outcomes into a poor outcome subgroup (367 cases) and a normal delivery subgroup (1,015 cases). Serum PLGF, sFlt-1, and sFlt-1/PLGF levels were measured and analyzed in relation to pregnancy outcomes. Results: The PE group exhibited significantly lower PLGF levels and higher sFlt-1 and sFlt-1/PLGF levels compared to the control group. Within the PE group, the sPE subgroup had significantly lower PLGF and higher sFlt-1/PLGF levels than the mPE subgroup. Patients with adverse outcomes showed significantly higher sFlt-1 and sFlt-1/PLGF levels compared to those with normal delivery outcomes. Spearman correlation analysis indicated a negative correlation between PLGF levels and adverse pregnancy outcomes (ρ = -0.057, P < 0.05), and a positive correlation of sFlt-1 and sFlt-1/PLGF levels with adverse outcomes (ρ = 0.075 and 0.082, respectively; both P < 0.01). Conclusion: Lower serum PLGF and higher sFlt-1 and sFlt-1/PLGF levels are significantly associated with PE and adverse pregnancy outcomes, underscoring their potential as biomarkers for predicting pregnancy complications in PE patients.

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Elevated Serum level of soluble Programmed Death-1 and C-Reactive Protein as biomarkers of Immune Dysregulation in Preeclampsia: Implications for Early Detection

Wondmagegn,

Sisay,

Abere

et al. 2024

Preprint

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Background Preeclampsia is a serious pregnancy related hypertensive condition with potentially life-threatening complications for the mother and fetus. its immunopathogenesis involves complex immune responses characterized by systemic inflammation and immune dysregulation. Soluble Programmed Death-1 (sPD-1) is an immune checkpoint has been implicated in immune exhaustion, and C-reactive protein (CRP) is an inflammatory marker associated with adverse pregnancy outcomes. Monitoring the levels of serum sPD-1 and CRP in preeclamptic pregnancies may be used as biomarkers for disease severity, immune dysregulation, and early detection of preeclampsia. Objective This study aimed to determine the levels of sPD-1 and CRP in preeclamptic patients, explore their association with proteinuria, and determine their potential as diagnostic markers for preeclampsia and disease severity. Methods A cross-sectional study was conducted at the University of Gondar specialized hospital. 79 pregnant women were included; of these, 39 had preeclampsia and 40 were age matched normotensive controls. Levels of CRP and sPD-1 were measured using enzyme-linked immuno sorbent assay (ELISA)and Quick read go CRP analyzer, and proteinuria was categorized using urine dipstick tests into three levels (+ 1, + 2, +3). Statistical analysis was performed to examine the median difference in sPD-1 and CRP level between preeclamptic women and normotensive controls, as well as across different proteinuria levels of preeclamptic women Results Preeclamptic women have higher median sPD-1 (5616 pg/L, IQR: 4592–7422 vs 4347 pg/L, IQR: 3885–4939) and CRP levels (4.5 mg/L, IQR: 3.8–5.3) than normotensive controls (4347 pg/L, IQR: 3885–4939 and 2.6 mg/L, IQR: 2.2–3.0 respectively). But there was no significant difference in sPD-1 and CRP levels across different categories of proteinuria levels in preeclamptic women. Conclusion In conclusion, Preeclamptic women have higher median sPD-1 and CRP levels than normotensive control, indicating a potential link between these biomarkers and the pathology of preeclampsia. However, sPD-1 and CRP levels does not differ across different proteinuria categories in preeclamptic women.

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Association of sFlt-1 and C-reactive protein with outcomes in severe preeclampsia

Cited by 3 publications

References 32 publications

Thyroid-stimulating hormone and total bile acids can predict adverse pregnancy outcome among patients with gestational hypertension

Thyroid-stimulating hormone and total bile acids can predict adverse pregnancy outcome among patients with gestational hypertension

Assessing the Prognostic Value of Serum PLGF, sFlt-1, and sFlt-1/PLGF Ratios in Predicting Adverse Pregnancy Outcomes in Preeclampsia: A Comprehensive Analysis

Elevated Serum level of soluble Programmed Death-1 and C-Reactive Protein as biomarkers of Immune Dysregulation in Preeclampsia: Implications for Early Detection

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