Association of Signal Transducer and Activator of Transcription 3 Gene Polymorphisms with Cervical Cancer in Chinese Women

Abstract

Signal transducer and activator of transcription (STAT) plays an important role in regulating cell proliferation, differentiation, and apoptosis. Previous studies revealed that abnormal expression/activation of STAT family members were present in a large group of human malignant tumors. In the present study, using polymerase chain reaction (PCR)-restriction fragment length polymorphism, DNA sequencing, and Taqman probe real-time PCR techniques, we analyzed two single-nucleotide polymorphisms (SNPs) in the STAT5B and STAT3 genes (rs6503691 and rs4769793, respectively) in 275 Chinese cervical cancer patients and 340 controls. Our results indicated that the genotype and allele frequencies of SNP rs4769793 were significantly different between the cervical cancer patients and normal subjects (p < 0.05, odds ratio = 1.35, 95% confidence interval = 1. 07-1.70). In addition, stratified analyses revealed that the polymorphism of rs4769793 was also associated with poor tumor differentiation and positive parametrial invasion (p < 0. 05). In contrast, SNP rs6503691 did not show any difference between patients and controls or association with patient clinical characteristics. Collectively, these findings suggested that STAT3 gene polymorphism (rs4769793) was associated with the susceptibility as well as poor differentiation and parametrial invasion of cervical cancer in Chinese women.

WITHDRAWN: Interleukin-21 receptor gene polymorphism is associated with hepatitis B virus-related hepatocellular carcinoma in Chinese patients

“…Moreover, polymorphisms in the IL21-JAK-STAT signaling pathway are associated with cardiovascular disease [26], breast cancer [27], renal cell carcinoma [28] and chronic myelogenous leukemia [29]. IL-21 gene polymorphisms such as rs12508721 T/C and rs2221903 A/G are also recognized as risk factors for HBV-related HCC and chronic HBV infections [30].…”

STAT3 rs3816769 polymorphism correlates with gene expression level and may predispose to nonsmall cell lung cancer: a preliminary study

“…[14][15][16][17][18][19][20][21] Moreover, the association between single nucleotide polymorphisms (SNPs) of STAT3 and susceptibility to carcinogenesis has been confirmed. 22,23 Additionally, it has been recognized that increased expression of STAT3 correlates with tumor progression and invasiveness; however, the causal mechanism of this molecular alteration and its prognostic value still remain unclear. Up to now, there have been few studies focused on SNPs in the STAT3 gene and their effect on gene expression, as well as their correlation with NSCLC risk, especially in the European population.…”

rs744166 Polymorphism of theSTAT3Gene Is Associated with Risk of Gastric Cancer in a Chinese Population

“…Recently, increasing evidence shows that polymorphisms of the STAT3 gene are associated with various diseases [21, 31–33]. In a large German cohort study, a significant association was observed between the minor allele of STAT3 rs744166 and Crohn's disease (OR = 0.83, 95% CI = 0.688–0.998, and P = 0.04) [31].…”