Association of Single Nucleotide Polymorphisms of Adiponectin Gene with Type 2 Diabetes Mellitus, and Their Influence on Cardiovascular Risk Markers

Momin, Abdulrahaman A.; Bankar, Mangesh P; Bhoite, Gouri M

doi:10.1007/s12291-016-0573-x

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…A study conducted on an Indian population diagnosed with T2D showed a positive correlation between the rs266729 polymorphism and high cholesterol/LDL levels, whereas its influence was null on HDL levels. The same study also suggests that this polymorphism may play a role in the development and progression of CVDs (Momin et al, 2017).…”

Section: Discussionmentioning

confidence: 63%

ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

León-Cachón¹,

Salinas-Santander²,

Aguilar-Tamez³

et al. 2022

J Appl Biomed

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Background:The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose and fatty acids. However, previous association studies between ADIPOQ genetic variants and metabolic disorders have shown controversial results. In this study, we evaluated the effect of the ADIPOQ-rs2241766 polymorphism on diverse biochemical parameters (i.e., insulin resistance, atherogenic index, overweight and obesity) in an adolescent population from Mexico. Methods: A cross-sectional study with convenience sampling was carried out in 356 adolescents from Northern Mexico. They were classified by sex and BMI-z score. The biochemical parameters were measured from blood samples using conventional methods. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In low and normal weight groups, GG carriers had a significantly higher cholesterol level (P ≤ 0.05) than TG and TT carriers. However, there was no association between ADIPOQ-rs2241766 polymorphism and atherogenic index, overweight, or obesity. Conclusions: Our findings suggest that the cholesterol levels are under the influence of the ADIPOQ-rs2241766 polymorphism in Mexican adolescents and may explain how ADIPOQ variants increase the risk of developing metabolic disorders. Nevertheless, further studies are required to rule out the influence of other genetic and non-genetic factors.

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Section: Discussionmentioning

confidence: 63%

ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

León-Cachón¹,

Salinas-Santander²,

Aguilar-Tamez³

et al. 2022

J Appl Biomed

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“…The adiponectin, a 30kDa protein, is encoded by the gene APM1/ADIPOQ consisting of three exons and two introns located on chromosome 3q27, where a locus of diabetes susceptibility was mapped [ 13 ]. Until now, 19 common polymorphisms of 14 known candidate genes have been analyzed around the world for their contribution to the prevalence and incidence of glucose intolerance [ 14 ]. While there is strong evidence that several polymorphisms are responsible for plasma adiponectin variation, the precise mechanisms underlying the association of these genetic variants in adiponectin with circulating adiponectin levels and metabolic traits remain unclear and have yet to be recognized.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review

Howlader

Sultana

Akter

et al. 2021

Heliyon

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Diabetes is currently a growing concern of the age. Prevention and treatment of diabetes is a global health priority. Adiponectin is an adipocyte derived protein hormone that enhances insulin sensitivity and ameliorates diabetes by enhancing fatty acid oxidation and glucose uptake in skeletal muscle and reducing glucose production in the liver. Low serum adiponectin concentrations are associated with diabetes, central obesity, insulin resistance and metabolic syndrome. Adiponectin gene is located on chromosome 3q27, where a locus of susceptibility to diabetes was mapped. Several cross-sectional studies showed that single nucleotide polymorphisms (SNPs) in adiponectin gene (ADIPOQ) were associated with diabetes. SNPs in ADIPOQ help in assessing the association of common variants with levels of adiponectin and the risk of diabetes. Two common SNPs, rs2241766 and rs1501299, have been linked significantly to type 1 diabetes mellitus which endow the world with a block of haplotypes. Experimental evidences also suggest that rs1501299, rs2241766, rs266729, rs17366743, rs17300539, rs182052, rs822396, rs17846866, rs3774261 and rs822393 are significantly associated with type 2 diabetes mellitus which is the predominant form of the disease. In addition, rs2241766 and rs266729 are extensively associated with gestational diabetes, a condition that develops in women during pregnancy. Therefore not a particular single mutation but a number of SNPs in adiponectin gene could be a risk factor for developing diabetes among the individuals worldwide. This study firmly suggests that adiponectin plays a crucial role in the pathogenesis of type 1, type 2 and gestational diabetes mellitus.

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“…The loss of pancreatic beta cells, and subsequent impairment of compensation for insulin resistance, contribute to the development of type 2 diabetes mellitus (T2 DM). [1][2][3][4][5] Increased serum free fatty acids (FFAs), in conjunction with hyperglycemia, are believed to induce a synergistic loss of beta cells in T2 DM; this is termed 'glucolipotoxicity'. 6 In fact, long-term exposure to saturated FFAs induces cell death in insulin-producing beta cells and isolated human islets, 7,8 and exposure to an elevated concentration of glucose augments FFA-induced cell death.…”

Section: Introductionmentioning

confidence: 99%

Curcumin protects islet cells from glucolipotoxicity by inhibiting oxidative stress and NADPH oxidase activity bothin vitroandin vivo

Chen

et al. 2019

Islets

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Curcumin possesses medicinal properties that are beneficial in various diseases, such as heart disease, cancer, and type 2 diabetes mellitus (T2 DM). It has been proposed that pancreatic beta cell dysfunction in T2 DM is promoted by oxidative stress caused by NADPH oxidase over-activity. The aim of the present study was to evaluate the efficacy of curcumin as a protective agent against high glucose/palmitate (HP)-induced islet cell damage and in streptozotocin (STZ)induced DM rats. INS-1 cells were exposed to HP with or without curcumin. Cell proliferation, islet cell morphological changes, reactive oxygen species production, superoxide dismutase and catalase activity, insulin levels, NADPH oxidase subunit expression, and the expression of apoptotic factors by INS-1 cells were observed. Our results show that curcumin can effectively inhibit the impairment of cell proliferation and activated oxidative stress, increase insulin levels, and reduce the high expression of NADPH oxidase subunits and apoptotic factors induced by HP in INS-1 cells. The STZ-induced DM rat model was also used to determine whether curcumin can protect islets in vivo. Our results show that curcumin significantly reduced pathological damage and increased insulin levels of islets in STZ-induced DM rats. Curcumin also successfully inhibited the high expression of NADPH oxidase subunits and apoptotic factors in STZ-induced DM rats. These results suggest that curcumin is able to attenuate HP-induced oxidative stress in islet cells and protect these cells from apoptosis by modulating the NADPH pathway. In view of its efficiency, curcumin has potential for translation applications in protecting islets from glucolipotoxicity.

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Association of Single Nucleotide Polymorphisms of Adiponectin Gene with Type 2 Diabetes Mellitus, and Their Influence on Cardiovascular Risk Markers

Abstract: Type 2 diabetes mellitus is a genetically heterogeneous condition, characterized by insulin deficiency and/or insulin resistance.

Cited by 7 publications

References 30 publications

ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review

Curcumin protects islet cells from glucolipotoxicity by inhibiting oxidative stress and NADPH oxidase activity bothin vitroandin vivo

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