Association of Single Nucleotide Polymorphisms in the FABP4 Gene with Carcass Characteristics and Meat Quality in Holstein Bulls

Abstract

the aim of this study was to characterize the bovine fatty acid binding protein (FABP4) gene 3691g>A and 2834c>g polymorphisms and to evaluate interaction effects on the live weight, carcass characteristics and meat quality of holstein bulls in the south marmara region of turkey. A total of 400 holstein bulls grown on a private farm and slaughtered at 14-21 months of age, were randomly selected for use in this study. initially, genotyping was performed by pcr-rflp method and statistical analysis was carried out using least square methods of the glm procedure. A snp located in intron 1 (2834c>g) was associated with desirable increases in live weight, hot carcass weight and chilled carcass weight, and a snp located in exon 3 (3691g>A) was associated with significant increases in marbling scores and first compressive stress point of the longissimus dorsi muscle (p<0.05). the interaction analysis of the 3691g>A and the 2834c>g polymorphisms revealed significant effects for hot carcass weight, chilled carcass weight and backfat thickness (P<0.05). There were no significant associations between the SNPs and carcass measurements. results indicated that the FABP4 3691g>A and 2834c>g polymorphisms and the 3691g>A and 2834c>g interactions can be used as selection parameters in breeding programmes to improve meat yield and carcass characteristics.

Identification of the association between &lt;i&gt;FABP4&lt;/i&gt; gene polymorphisms and milk production traits in Sfakia sheep

“…For example they might affect the splicing of mRNA or be linked to variation elsewhere in a regulatory region (e.g., a miRNA binding site or enhancer binding site), or the 5 -UTR or 3 -UTR regions (UTR is untranslated region), that subsequently affects expression of the amino acid sequence (Wessagowit et al, 2005;MartõÂnez-Pizarro et al, 2018). Previous reports have demonstrated associations between genetic variation in FABP4 and carcass traits, meat quality traits, and fatty acid composition in adipocytes (Ardicli et al, 2017;Yan et al, 2018). Limited information is available regarding the effect of FABP4 on milk production traits in livestock.…”

“…The effects of FABP4 variation on milk production traits might also be explained by other phenomena. Besides its direct effects on milk production traits, FABP4 has been shown to have an effect on residual feed intake and feed efficiency (Cohen-Zinder et al, 2016), subcutaneous fat depth and fatty acid composition of carcass (Hoashi et al, 2008), intramuscular fat (Lee et al, 2010), marbling score and back-fat thickness (Ardicli et al, 2017), and insulin resistance (Hotamisligil and Bernlohr, 2015). Many investigations have shown associations between milk production traits and these traits.…”

Individual and combined effects of &lt;i&gt;CAPN1&lt;/i&gt;, &lt;i&gt;CAST&lt;/i&gt;, &lt;i&gt;LEP&lt;/i&gt; and &lt;i&gt;GHR&lt;/i&gt; gene polymorphisms on carcass characteristics and meat quality in Holstein bulls

“…Considering the approximately 14 million total cattle count, the Holstein breed has a significant impact on Turkish animal husbandry (Turkish Ministry of Food, Agriculture and Livestock Database, 2015). Therefore, evaluating the potential of Holstein meat can be considered as a strategically important point in breeding programmes and meat production (Ardicli et al, 2017a).…”

Genetic Variation in the Ovine Fatty Acid Binding Protein-4 (Fabp4) Gene and Its Association With Live Performance and Carcass Traits in Egyptian Ossimi Lambs

“…Table 1 show that the frequency of allele A was higher (73%) than that of allele B (27%) . Shin et al (2012) and Ardicli et al (2017) reported that the frequency of allele B was higher (67%) than that of allele A. In this concept, the allele and genotype frequencies are known to vary between breeds and even between the different populations within the same breed (Ardicli et al, 2017).…”

“…Also, it was found that FABP4 is a very important candidate gene for the quantitative trait locus and which affects fatty acid deposition and growth performance in pigs (Ojeda et al, 2006) and chicken (Wang et al, 2006). On the other hand, some studies (Shin et al, 2012 andArdicli et al, 2017) did not detect an association between the absence/presence of the alleles in the FABP4 genotype and carcass traits in cattle. The present results support the idea that FABP4 variation may be affect positively the growth and carcass traits in Egyptian Ossimi lambs.…”