Association of Single Nucleotide Polymorphisms in the Apoptosis-Related Genes &lt;i&gt;TP63&lt;/i&gt; and &lt;i&gt;CD40 &lt;/i&gt;with Risk for Lung Cancer in a Chinese Han Population

Tang, Wenjun; Xue, Li; Yan, Qi-Xing; Cai, Shaoxi; Bai, Yujie; Li, Lin; Lin, BiLin; Huang, MingLong; Yi, Guohui; Li, Hui

doi:10.1620/tjem.238.279

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…These SNPs had been broadly researched in different genetic backgrounds. It turned out that rs1535045 had connection to many diseases, such as coronary artery calcification [23] and small cell lung cancer [11], and rs1883832 was related to systemic lupus erythematosus [24] and acute coronary syndrome [25].…”

Section: Discussionmentioning

confidence: 99%

CD40 polymorphisms were associated with HCV infection susceptibility among Chinese population

Tian

Huang

et al. 2019

BMC Infect Dis

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Background CD40, encoded by TNFRSF5, participates in the survival of B cells, process of antigen presentation and generation of CD8+ T cell memory. It also has an important effect on HCV antiviral immune response. This study aims to investigate whether TNFRSF5 gene polymorphisms are associated with HCV infection outcomes among Chinese population. Methods Three single nucleotide polymorphism (SNPs) (rs1535045, rs1883832, rs4810485) on TNFRSF5 were genotyped by TaqMan assay among Chinese population, including 1513 uninfected subjects, 496 spontaneous viral clearance subjects and 768 persistent HCV-infected subjects. Logistic analysis was used to compare these SNPs among different groups in this cross-sectional study. Functional annotations of the identified SNPs were further evaluated by bioinformatics analysis. Results After adjusted by age, gender and routes of infection, the results of logistic analysis indicated that individuals carrying rs1535045 T allele had a higher risk to infect HCV compared with C allele (in recessive model, adjusted OR = 1.368, 95%CI = 1.070-1.749, P = 0.012). Subjects carried rs1535045 TT genotype were more likely to infect HCV than wild CC genotype (adjusted OR = 1.397, 95%CI = 1.078-1.809, P = 0.011). For rs1883832, T allele was significantly associated with an increased risk of HCV infection (in recessive model, adjusted OR = 1.337, 95%CI = 1.069-1.673, P = 0.011). Subjects with TT genotype had more possibility to infect HCV (adjusted OR = 1.351, 95%CI = 1.060-1.702, P = 0.015). In the stratified analysis, rs1535045 and rs1883832 were remained in various subgroups and the heterogeneity test showed no pronounced heterogeneity in any pairwise comparison (all P > 0.05). In addition, the results of the cumulative effects showed a tendency of that the more risk alleles (rs1535045 T and rs1883832 T) subjects carried, the more possibility of HCV infection exhibited (P<0.001). In haplotype analyses, compared with the CC haplotype, CT, TC and TT was correlated with an increased risk to infect HCV (P = 0.029, P = 0.047 and P<0.001, respectively). Conclusions In conclusion, CD40 polymorphisms were significantly associated with the susceptibility to HCV among Chinese populations.

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Section: Discussionmentioning

confidence: 99%

CD40 polymorphisms were associated with HCV infection susceptibility among Chinese population

Tian

Huang

et al. 2019

BMC Infect Dis

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“… 35 In a case-control study by Tang and colleagues (2016) genotyping SNPs of the intron 9 of TP63 rs6790167 (g243059A>G) in the non-smoking Chinese Han population, they found that the frequency of the CC genotype of rs1535045 was significantly higher in non-smoking lung cancer female patients, while the GG genotype of rs6790167 was significantly higher in non-smoking lung cancer male patients. 20 Lung cancer has the second-highest incidence among males and females, but there is a higher incidence among males, with a male-to-female ratio of 1.5–2.0. Interestingly, it has been noticed that lung cancer mortality is decreasing among males while it continues to increase among females.…”

Section: Molecular Differencesmentioning

confidence: 99%

Molecular basis of sex differences in cancer: Perspective from Asia

Ornos¹,

Cando²,

Catral³

et al. 2023

iScience

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“…In vivo studies have shown that the expression of CD40 is correlated with HPV positivity, vascular endothelial growth factor (VEGF) expression, and microvessel density [ 27 , 30 ]. In recent years, various studies have shown that CD40 gene polymorphisms are related to some malignant tumors, such as non-Hodgkin’s lymphoma [ 31 ], breast cancer [ 32 ], and lung cancer [ 33 , 34 ]. However, there were few reports on the relationship between the CD40 gene and cervical cancer [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of CD40 gene polymorphisms on the risk of cervical squamous cell carcinoma: a case-control study

Zhu,

Li,

Feng

et al. 2023

BMC Cancer

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Background Cervical cancer is the fourth most common cancer among women worldwide. Genome-wide association studies have revealed multiple susceptible genes and their polymorphisms for cervical cancer risk. Therefore, we aimed to investigate the correlation between single nucleotide polymorphisms (SNPs) of the CD40 gene and susceptibility to cervical squamous cell carcinoma (CSCC) in a population from the northeastern Han Chinese population. Methods The three SNPs (rs1800686, rs3765459, and rs4810485) of the CD40 gene were analyzed by multiplex polymerase chain reaction (PCR) combined with next-generation sequencing methods in 421 patients with CSCC, 594 patients with high-grade squamous intraepithelial lesions (HSIL), and 504 healthy females. Multivariate logistic regression analysis was used to analyze the potential relationship between CD40 gene polymorphisms and CSCC, or HSIL. Results Our research results showed the AA genotype of rs1800686 had a protective effect on CSCC in comparison to the GG genotype and AG+GG genotypes (AA vs. GG: p = 0.0389 and AA vs. AG+GG: p = 0.0280, respectively). After FDR correction, the results were still statistically significant (p = 0.0389 and p = 0.0389, respectively). Similarly, rs3765459 showed a reduced risk association for CSCC in the codominant and recessive models (AA vs. GG: p = 0.0286 and AA vs. AG+GG: p = 0.0222, respectively). Significant differences remained after FDR correction (p = 0.0286 and p = 0.0286, respectively). However, these differences were no longer significant after the Bonferroni correction. In addition, the genotypes for the rs4810485 polymorphisms were associated with parity of the patients with CSCC. The genotypes for the rs3765459 polymorphisms were significantly correlated with the D-dimer of the patients with CSCC. The 3 SNPs genotypes of the CD40 gene were closely related to the squamous cell carcinoma antigen (SCC) of the patients with HSIL. Conclusions The CD40 gene may play a role in the occurrence and development of CSCC.

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Association of Single Nucleotide Polymorphisms in the Apoptosis-Related Genes <i>TP63</i> and <i>CD40 </i>with Risk for Lung Cancer in a Chinese Han Population

Cited by 3 publications

References 26 publications

CD40 polymorphisms were associated with HCV infection susceptibility among Chinese population

CD40 polymorphisms were associated with HCV infection susceptibility among Chinese population

Molecular basis of sex differences in cancer: Perspective from Asia

Impact of CD40 gene polymorphisms on the risk of cervical squamous cell carcinoma: a case-control study

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