Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle1,2,3

Ge, Wei; Davis, Michael; Hines, H. C.; Irvin, K. M.; Simmen, Rosalia C. M.

doi:10.2527/2003.813641x

Cited by 109 publications

(129 citation statements)

References 29 publications

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“…Only one SNP was identified in a non coding region (intron 1) in position AJ575419:g.419C>T. It is noteworthy to state that numerous mutations in this gene were documented in other species, viz. in cattle more than 10 SNPs have been recorded (Chikuni et al, 1994;Ge et al, 2003;Musa, 2007). Also, many SNPs have been reported in sheep (Bastos et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Association of several polymorphic sites (SNPs) in different candidate genes with economic traits has been much investigated in different animal species. Work based on characterization of candidate genes and their association with animal performance in camels is meagre compared with cattle (Lucy et al, 1991;Schlee et al, 1994;Ge et al, 2003), sheep (Wallis et al, 1998;Bastos et al, 2001) or goats (Wallis et al, 1998;Neelam Gupta et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Phenotypic and molecular characterization of six Sudanese camel breeds

Ishag¹,

Reißmann²,

Peters³

et al. 2011

SA J. An. Sci.

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The objective of this study was to sequence the growth hormone (GH) gene in Sudanese camel breeds (Kenani, Lahwee, Rashaidi, Anafi, Bishari and Kabbashi) searching for single nucleotide polymorphisms (SNPs) and contribute to the phenotypic characterization of the multitude of camel ecotypes in Sudan. This will also afford the chance of investigating the possibility of the presence of correlations between body measurements and SNPs of GH gene. A length of 1732 bp, spanning the region between -44 bp upstream of the first exon and +37 bp downstream of the last exon was sequenced in two animals from each breed. The sequence comparison of Sudanese camel GH sequences with the GenBank sequence identified one single nucleotide polymorphism (SNP). The SNP was detected in the non coding region (intron 1) in position AJ575419:g.419C>T. A PCR-RFLP method was used to genotype 181 animals representing the six tested Sudanese breeds for detected SNP. The Bishari and Anafi breeds that are classified as riding camels had slightly higher T allele frequencies (0.57 and 0.48, respectively) than those of the other four breeds which are classified as pack camels. The effect of genotype with regard to the SNP g.419C>T on those traits was not significant. ________________________________________________________________________________

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenotypic and molecular characterization of six Sudanese camel breeds

Ishag¹,

Reißmann²,

Peters³

et al. 2011

SA J. An. Sci.

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“…Teniendo en cuenta lo anterior, se debe tener en cuenta que para el desarrollo de un programa de selección asistido por marcadores moleculares, es pertinente realizar la evaluación a nivel local sobre el genotipo más deseado por su relación con parámetros productivos, debido a que los reportes son ambiguos (9,14,24) y pueden ser variables de acuerdo al lugar donde son evaluados y a la raza de los animales (24). Además, en Colombia no se han reportado asociaciones significativas entre el alelo MspI posiblemente porque la única investigación llevada a cabo por Echeverri et al (22), no poseía un numero de animales que permita lograr la significancia deseada.…”

Section: Figuraunclassified

“…Actualmente se conocen múltiples polimorfismos al interior del gen o en regiones reguladoras (9). Una de estas variantes reportadas corresponde a un sitio que puede ser reconocido por la endonucleasa de restricción MspI (10), el cual fue localizado como un polimorfismo en el intrón 3 en la posición 1547, que se debe a la transición de Timina, T a Citosina, C (11).…”

Section: Introductionunclassified

Estructura y diversidad genética en vacas Holstein de Antioquia usando un polimorfismo del gen bGH

2013

Rev MVZ Córdoba

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RESUMENObjetivo. Determinar las frecuencias alélicas y genotípicas del polimorfismo del intrón 3 del gen bGH y estimar algunos parámetros de estructura poblacional en ganado Holstein. Materiales y métodos. El estudio se realizó con 1366 vacas Holstein en 120 hatos de 11 municipios del departamento de Antioquia. Se extrajo DNA por el método de Salting out y la genotipificación se realizó usando la técnica de PCR-RFLPs. La diversidad genética se determinó mediante la comparación de las heterocigosidades, El equilibrio de Hardy-Weinberg (HW) y la diferenciación genética entre las poblaciones se realizó usando el software Arlequín 2.0 Las frecuencias alélicas y genotípicas se evaluaron mediante el paquete estadístico SAS ® . Resultados. Las frecuencias genotípicas encontradas fueron 0.764 (+/+), 0.223 (+/-) y 0.013 (-/-) y las frecuencias alélicas 0.876 (+) y 0.124 (-). No se encontraron desviaciones del Equilibrio de Hardy Weinberg en ninguna de las subpoblaciones. La diversidad genética determinada mediante la comparación de las heterocigosidades fue relativamente baja entre poblaciones pero al interior de estas no. El valor de FST de toda la población fue de 0.0068 y significativo (p<0.05), algunos FST pareados también lo fueron, tomando valores desde 0.0 a 0.13. Los estadísticos FIT y FIS no fueron significativos. Conclusiones. El gen bGH es un candidato interesante para evaluar características de importancia económica ya que no parece haber sido sometido a selección directa, presenta una variabilidad media en las poblaciones, observándose diferenciación genética significativa entre distintos municipios, producto de los diferentes sistemas de producción y acceso a las biotecnologías.Palabras clave: Ganado lechero, genética de poblaciones, marcadores moleculares, polimorfismo (Fuente:AGROVOC). ORIGINALRev. MVZ Córdoba 18(1):3346-3354, 2013.

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“…There are several distinct 5 untranslated region (exon 1) variants in mouse (L1-L5) as well as human GHR (V1-V9), and expression of each transcript is regulated by a different promoter (Edens & Talamantes 1998, Menon et al 2001. Several polymorphisms in the promoter region of GHR gene were reported in species including humans (Hadjiyannakis et al 2001), Angus steers (Hale et al 2000) and Angus cattle (Ge et al 2003), although hitherto there has been no report in mice. Interestingly, the polymorphisms in humans located at 87 bp upstream of V9 (Hadjiyannakis et al 2001), homologous to mouse L3, correspond to those we found in mice.…”

Section: Figurementioning

confidence: 99%

Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels

Iida¹,

Rosen²,

Ackert‐Bicknell³

et al. 2005

Journal of Endocrinology

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There is significant heterogeneity in serum IGF-I concentrations among normal healthy individuals across all ages and among inbred strains of mice. C3H/HeJ (C3H) mice have 30% higher serum IGF-I concentrations over a lifetime than C57BL/6J (B6), even though body size and length are identical. The underlying mechanism for this disparity remains unknown although several possibilities exist including altered GH secretion, resistance to GH action, or impaired IGF-I secretion from the liver or peripheral tissues. To study this further, we evaluated mRNA levels of pituitary GH, and of IGF-I, GH receptor (GHR) and acid-labile subunit (ALS) in liver and skeletal muscle of male C3H and B6 strains. mRNA levels of hepatic IGF-I paralleled serum IGF-I levels, whereas pituitary GH mRNA expression was significantly lower in C3H than B6. In addition, reduced hepatic mRNA levels of ALS and GHR in B6 suggests hepatic GH resistance in B6. In contrast, mRNA levels of IGF-I and GHR in skeletal muscle were not different between B6 and C3H. There was a single sequence repeat polymorphism (SSR) in the promoter region of both GHR and IGF-I genes in mice; the SSR in the IGF-I gene was significantly different between the two strains. The SSR in the IGF-I gene corresponds to the E2F binding site, which is critical for regulating IGF-I gene expression. These results suggest that the SSR in the promoter region of the IGF-I gene may be partially responsible for differences in serum IGF-I levels between B6 and C3H strains.

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Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle1,2,3

Cited by 109 publications

References 29 publications

Phenotypic and molecular characterization of six Sudanese camel breeds

Phenotypic and molecular characterization of six Sudanese camel breeds

Estructura y diversidad genética en vacas Holstein de Antioquia usando un polimorfismo del gen bGH

Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels

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