Association of single nucleotide polymorphisms with taste and food preferences of the Hungarian general and Roma populations

Diószegi, Judit; Kurshed, Ali Abbas Mohammad; Pikó, Péter; Kósa, Zsigmond; Sándor, János; Ádány, Róza

doi:10.1016/j.appet.2021.105270

Cited by 10 publications

(10 citation statements)

References 158 publications

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“…An interesting thing was that several hub genes were involved in the neurological or psychiatric function or disorders such as CHRM4 [70,71], MTNR1B [72], and TAS2R19 [73,74]. Just as reported, plentiful common proteins and biochemical characteristics were shared between the human brain and testis [75].…”

Section: Discussionmentioning

confidence: 83%

Unearthing of key genes driving the infertility risk of cryptorchidism via weighted gene co- expression network

Lao

Zhang

et al. 2022

Preprint

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Background: Boys with cryptorchidism are susceptible to infertility. However, there are few known molecular markers of cryptorchidism-related infertility. Potential genes and molecular pathways to drive cryptorchidism-related infertility were investigated in this study via bioinformatics methods.Methods: Gene Expression Omnibus (GEO) database was utilized to download raw GSE25518 (training set) and GSE16191 (validation set) datasets. GSE25518 was used for differentially expressed genes (DEGs) identification and weighted gene co-expression network analysis (WGCNA). Hub genes were identified from the intersection of key genes from DEGs and the key module in WGCNA. Hub genes’ expression differences and diagnostic value were subsequently verified via GSE16191. Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and Gene set enrichment analysis (GSEA) were deployed for functional annotation.Results: 761 definitive DEGs were identified while 12 hub genes (CHRM4, CCR4, LMNB1, MTNR1B, TAC3, TRHR, RAD54L, CCNA1, SMC1B, GPRC6A, SYCE2, TAS2R19) were identified finally. The hub genes were also differentially expressed and showed excellent diagnostic value to distinguish cryptorchidism from normal testes in GSE16191. Additionally, they were well correlated with genes from the hallmark_spermatogenesis gene set. And they might be involved in oxidative phosphorylation, MYC targets V1, cholesterol homeostasis, KRAS activation, etc. Hallmark_spermatogenesis gene set was significantly enriched by five hub genes (RAD54L, CCNA1, SMC1B, TAC3, MTNR1B).Conclusion: We have identified 12 genes that might become new biomarkers for cryptorchidism-related infertility while five genes (RAD54L, CCNA1, SMC1B, TAC3, MTNR1B) deserve more attention.

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Section: Discussionmentioning

confidence: 83%

Unearthing of key genes driving the infertility risk of cryptorchidism via weighted gene co- expression network

Lao

Zhang

et al. 2022

Preprint

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“…The lack of research relating SNPs of sweet TP with other tastes is limited, especially between children. In adults, some authors were unable to con rm the association of SNPs in TAS1R2 and TAS1R3 with the preference for sweet foods or the amount of added sugar in the diet (Barragán et al, 2018;Diószegi et al, 2021), other studies stated that the greater perception of the sweet avor is related to the preference for bitter foods, both in man and women (Barragán et al, 2018), that adults with the TAS1R3(rs307355) SNP feel greater intensity in the sucrose solution, and greater sensitivity to sweet avor (Melis et al, 2022), and that the presence of the TAS1R3(rs35744813) SNP is related to greater suprathreshold sensitivity of the sweet taste (Chamoun et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Are there differences in taste preferences according to genetic polymorphisms? A study with children submitted to different methods of complementary feeding?

Neves,

Rechenmacher,

Borges

et al. 2024

Preprint

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Background The development of child taste preferences seems to play a crucial role in food preferences and health outcomes. This study aimed to analyze the differences in taste preferences according to genetic polymorphisms in children allocated to different methods of complementary feeding (CF). This was a secondary analysis derived from a randomized clinical trial involving distinct groups of children regarding the method of CF. The intervention occurred at 5.5 months old. At 12 months old, the Feeding Preferences Questionnaire (FPQ) was applied. Between 12–35 months old, the Taste Acceptance Test (TAT) was performed and oral mucosa was collected. Data were analyzed by intention to treat. The main analyses were performed using Pearson’s chi-square test. Results The duration of exclusive breastfeeding was associated with TAS1R3(rs35744813) (p = 0.039). The type of milk consumed at 12 months was associated with TAS1R2(rs9701796) (p = 0.022), and with the number of polymorphisms related to sweet taste perception (p = 0.013). As for the FPQ, there was an association between TAS1R3(rs35744813) with the preference for sour-tasting foods (p = 0.040), and between TAS2R16(rs846672) with the preference for umami-flavored foods (p = 0.042). Concerning the TAT, the infant’s reaction to the bitter taste was associated with TAS1R2(rs9701796) (p = 0.021), with TAS1R3(rs307355) (p = 0.008), and with the count of polymorphisms related to the sweet taste perception (p = 0.037); in addition, the reaction to the sour taste was associated with the count of polymorphisms related to the bitter taste perception (p = 0.048). Conclusions The study concluded that genetic polymorphisms act on infant food acceptance, generating differences in food preferences.

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“…Previous studies showed that people with the AA/AG genotype at rs1761667 of CD36 consumed more fatty foods than control subjects (GG) (Roper & Chaudhari, 2017, Karthi et al, 2021). Also, a recent study found that the CD36 variation at rs1527483 is associated with an increased intake of fatty foods in overweight/obese individuals (Diószegi et al, 2021; Meng et al, 2021). Consequently, it appears that distinct CD36 SNPs affect the detection of dietary fat, which might lead to minor variations in habitual fat intake over time that could affect bodyweight and chronic disease risk.…”

Section: Discussionmentioning

confidence: 99%

“…Single nucleotide polymorphisms (SNPs) are a type of genetic variation caused by a single nucleotide change at a particular locus. These SNPs in the taste receptor gene create subgroups within a population that have variable responses to food (Diószegi et al, 2021) with potential effects on how many calories are consumed and therefore ease of weight gain and loss. Due to the rising incidence of overweight and obesity among all age groups, developing safe and effective anti‐obesity therapies is crucial (Meng et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake

et al. 2023

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There is a lack of research on the combined effects of genetic variations (specifically CD36 SNPs—rs1761667 and rs1527483), dietary food habits (vegetarian or not), and the salivary environment on obesity and taste sensitivity, especially in the Indian population. The current study aims to better understand the relationship between impaired taste perception, fat consumption, higher BMI and obesity development by examining the combined association between CD36 SNPs, oleic acid (OA) detection threshold, and food habits among Indian participants. Furthermore, the relationship between oral fatty acid (FAs) sensitivity and taste physiology factors linked to inflammation and salivary proteins was considered. Participants with the minor allele (AA/AG) of CD36 (in both rs1527483 and rs1761667) consumed more fat, particularly saturated FAs (p = 0.0351). Salivary lipopolysaccharide, which causes inflammation, was significantly greater in non‐vegetarians with a higher BMI (p < 0.05), and it exhibited a negative correlation (r = −0.232 and p < 0.05) with Ki67 gene expression, a marker for taste progenitor cells. A positive correlation (r = 0.474, p = 0.04) between TLR4 mRNA levels and the OA detection threshold was also observed. Participants with BMI > 25 kg/m2 had substantially higher TNF‐α and IL‐6 receptor mRNA expression levels, but there were no significant differences between the vegetarian and non‐vegetarian groups. However, salivary CA‐VI, which has a buffering capability on the oral environment, was lower in non‐vegetarian adults with BMI >25. Thus, it was shown that non‐vegetarians with overweight and obesity in India were in at‐risk groups for the CD36 SNP (AA/AG at rs1761667 and rs1527483) and had higher levels of inflammatory markers, which exacerbated alterations in food behaviour and physiological changes, indicating their relevance in the development of obesity.

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Association of single nucleotide polymorphisms with taste and food preferences of the Hungarian general and Roma populations

Cited by 10 publications

References 158 publications

Unearthing of key genes driving the infertility risk of cryptorchidism via weighted gene co- expression network

Unearthing of key genes driving the infertility risk of cryptorchidism via weighted gene co- expression network

Are there differences in taste preferences according to genetic polymorphisms? A study with children submitted to different methods of complementary feeding?

CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake

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