Association of single-nucleotide polymorphisms rs2197076 and rs2241883 of FABP1 gene with polycystic ovary syndrome

Xue, Hongtao; Zhao, Han; Liu, Xin; Zhao, Yong; Chen, Zi‐Jiang; Ma, Jinlong

doi:10.1007/s10815-015-0626-8

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…Regarding the FABP1 gene, Xue et al investigated the relationship between SNP rs2197076 and rs2241883 and PCOS. In their study of 221 PCOS women and 198 normal women, the authors found a close association with rs 2197076 and rs 2241883 polymorphisms in women with PCOS but no association with BMI [19]. In a study of 95 PCOS women and 45 healthy women, Rashid et al found that the allele and genotype frequency of IL-1β, IL-1Ra, and FABP1 gene polymorphisms did not differ between the PCOS and control groups.…”

Section: Discussionmentioning

confidence: 93%

Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism

Karakuz

Ekici

Topçuoğlu

et al. 2019

j-ebr

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Polycystic ovary syndrome (PCOS) is a multifactorial, endocrine, and metabolic disorder seen in 10%-20% of women of reproductive age. Due to the close relationship observed between the increased risk of type 2 diabetes and insulin resistance and the polymorphism of the fatty acid binding protein 1 (FABP1) gene rs2197076 single nucleotide polymorphism (SNP), we investigated the frequency of the FABP1 gene rs2197076 SNP in patients with PCOS. Methods: This is a prospective case-control study. The study included 151 women-75 patients with PCOS and 76 healthy women. A real-time polymerase chain reaction was performed for the FABP1 rs2197076 polymorphism. Additionally, biochemical and hormonal levels of the patients were studied. Results: Menstrual irregularities, the body mass index (BMI), hirsutism scores, the luteinizing hormone / follicular stimulating hormone ratio, dehydroepiandrosterone sulfate and testosterone levels were significantly higher in the PCOS group than in the control. There was no significant difference between the PCOS and control groups in terms of FABP1 rs2197076 genotype distribution and FABP1 rs2197076 allele frequency distribution. Conclusion:There was no increase in the genotype distribution and allelic frequency of the FABP1 gene rs2197076 SNP in PCOS patients. Further studies are needed on this subject.

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Section: Discussionmentioning

confidence: 93%

Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism

Karakuz

Ekici

Topçuoğlu

et al. 2019

j-ebr

View full text Add to dashboard Cite

show abstract

“…Secondly, environmental factors might also influence the relationship between TNF-α/IL-1/IL-6/IL-10 polymorphisms and PCOS. However, most investigators only focused on genetic associations in their works, and so the geneticenvironmental interactions were not explored in this meta-analysis [21]. Thirdly, we did not consider grey literature.…”

Section: Discussionmentioning

confidence: 99%

Common cytokine polymorphisms and predisposition to polycystic ovary syndrome: a meta-analysis

et al. 2020

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The results of studies on the relationship between cytokine polymorphisms and polycystic ovary syndrome (PCOS) have been controversial. This meta-analysis was thus designed to more precisely assess the relationship between TNF-α/IL-1/ IL-6/IL-10 polymorphisms and PCOS by pooling the results of published studies. A search of PubMed, Embase, Web of Science, and CNKI databases turned up 23 studies that were pooled and analyzed in this meta-analysis. The overall results showed that the distributions of TNF-α -

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“…This genetic differentiation although low in absolute Fst values should be taken into account during association studies. We identified 10 medically relevant SNVs with statistically significant allele differences between the NVSB and NFE populations including rs2241883 in FABP1 gene previously associated with polycystic syndrome [21] and toxicity of fenofibrate [22], rs1801274 variant in FCGR2A gene shown to be important for the efficiency of trastuzumab in breast neoplasms [23], the rare rs17879961 variant in CHEK2 gene reliably associated with predisposition to breast and colorectal cancer [24] and showed elevated frequency in NVSB. These variants should be studied in future on an expanded dataset with associated clinical data.…”

Section: Discussionmentioning

confidence: 99%

Exome-wide survey of the Siberian Caucasian population

2019

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Background Population structure is an important factor in the genetic association studies but often remains underexplored for many human populations. We identified exome variants in 39 Siberian Caucasian individuals from Novosibirsk, Russia and compared their genetic allele frequencies with European populations from 1000 Genomes Project. Methods The study participants were from Novosibirsk and represented people with monogenic diabetes, healthy individuals and a cohort from the tick-borne encephalitis study. Isolated DNA was enriched using Agilent SureSelect V5 kit and sequenced on Illumina HiSeq 4000 and genetic variants were identified using GATK pipeline. To estimate the patterns of the population structure we used PCA and ADMIXTURE analysis. Pharmocogenetically and medically important variants were annotated based on PharmGKB and ClinVar databases. Results The analysis identified low, but highly significant population differentiation attributed to numerous loci between the Siberian Caucasian population and other European population samples as well as a higher proportion of the Finnish genetic component in the studied sample. The medical and pharmacogenetic annotation of highly significantly differentiated variants between the Novosibirsk and the combined European populations revealed a number of important genetic polymorphisms located in such genes as FCGR3B , TYR , OCA2 , FABP1 , CHEK2 and SLC4A1 . Conclusions The study reports for the first time an exome-wide comparison of a population from Russia with European samples and emphasizes the importance of population studies with medical annotation of variants.

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Association of single-nucleotide polymorphisms rs2197076 and rs2241883 of FABP1 gene with polycystic ovary syndrome

Abstract: In the association of SNPs in FABP1 gene with PCOS, rs2197076 was more closely associated with its main features than rs2241883 and seemed to play a more important role in the pathogenesis of PCOS.

Cited by 11 publications

References 35 publications

Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism

Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism

Common cytokine polymorphisms and predisposition to polycystic ovary syndrome: a meta-analysis

Exome-wide survey of the Siberian Caucasian population

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