Association of single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer risk in Indian population

Kohaar, Indu; Tiwari, Pratibha; Kumar, Rakesh; Nasare, Vilas; Thakur, Nisha; Das, Bhudev C.; Bharadwaj, Mausumi

doi:10.1007/s10549-008-0006-5

Cited by 54 publications

(54 citation statements)

References 44 publications

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“…Two SNPs located at nucleotides À238 and À308 have been extensively researched on the susceptibility to a range of autoimmune disorders, including rheumatoid arthritis, 9 exfoliation glaucoma, 10 and many kinds of cancers. [11][12][13] The hypothesis that TNF-a-308 G4A may have important roles in the development of UC, CD, and CRC has been debated. The results of previous association studies were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis

Wang

Chen

et al. 2011

Eur J Hum Genet

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Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are common health problems worldwide. Tumor necrosis factor (TNF) is a type of cytokine that induces inflammation and inhibits tumorigenesis. Several studies have assessed the relationship between the polymorphism of TNF-a-308 G4A and the susceptibility to IBD and CRC; however, the results have been controversial. In addition, the hypothesis whether the increased risk of CRC in IBD patients could be partly ascribed to the polymorphism of TNF-a-308 G4A was unclear. Therefore, we conducted this meta-analysis to confirm these associations. Pooled odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated on the basis of data from 14, 18, and 7 studies from a total of 27 studies for the associations between the polymorphism of TNF-a-308 G4A and ulcerative colitis, Crohn's disease (CD) and CRC. In Europeans, the AA genotype increased the risk of ulcerative colitis (UC) (OR, 2.041; 95% CI, 1.261-3.301) and CD (OR, 1.730; 95% CI, 1.168-2.564) significantly, without obvious heterogeneity and publication bias. Meanwhile, the GA genotype increased the risk of UC in Asians (OR, 2.360; 95% CI, 1.269-4.390) significantly. However, no significant association was observed for CRC in any ethnic population. The results of this meta-analysis suggested that the polymorphism of TNF-a-308 G4A participates in modifying the susceptibility to UC and CD in Europeans and Asians. The increased risk of CRC in IBD patients should be clarified as the combined effects of polymorphisms in TNF-a and other cytokines, and the interaction with environmental factors, in future studies.

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Section: Introductionmentioning

confidence: 99%

Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis

Wang

Chen

et al. 2011

Eur J Hum Genet

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“…LTA is a crucial proinflammatory cytokine, which has multiple functions in immune system as TNF-α. The LTA +252G allele has been reported to increased LTA production by phytohemagglutininactivated mononuclear cells in vitro and have higher secretary capacity and circulatory concentrations of TNF-α (Messer et al, 1991;Pociot et al, 1993;Kohaar et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Lymphotoxin-α (LTA, TNF-β) is a cytokine which has a close structural homology and about 30% amino acid sequence identity to TNF-α, which are both recognized by the same widely distributed cellular TNF receptors and have similar effects (Smith et al, 1994). It is produced by diverse kinds of cells including macrophages, NK cells, T and B cells, and tumor cells et al (Anderson et al, 2004) and postulated to play a role in pathogenesis of cancers (Kobayashi et al, 1997;Kohaar et al, 2009). TNF-α and LTA polymorphisms were reported to be associated with cancers (Pooja et al, 2010), which had draw many researchers' attentions to in the breast cancer study.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, TNF-α polymorphisms were not found to be associated with the risk of BC in two meta-analysis studies (Fang et al, 2010). However, the results were inconsistent and ambiguous for LTA-252 A>G polymorphism studies (the most investigated site) (Park et al, 2002;KamaliSarvestani et al, 2005;Lee et al, 2005;Gaudet et al, 2007;Kohaar et al, 2009;Pooja et al, 2010;Karakus et al, 2011). Because a modest sample size and unified ethnicity of these studies, each of them might not achieve a reliable and stable conclusion, which indicate that a meta-analysis is needed to investigate this issue.…”

Section: Introductionmentioning

confidence: 99%

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The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

Zhou

Huang²,

Chu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC). Methods: Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified. Results: This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations. Conclusion: Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.

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“…Several recent studies have demonstrated an association between the TNFB þ 252 G allele and a higher risk of breast cancer and sarcoidosis, demonstrating a pivotal role for TNF-b in host cellular immunity. [31][32][33] Moreover, both TNFA and TNFB gene polymorphisms have been shown to be associated with TNF-a generation potential. Thus, TNFA and TNFB gene polymorphisms may have functional significance in diseases whose pathogenetic mechanisms include TNF-a production.…”

Section: Discussionmentioning

confidence: 99%

Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population

Xiao

Lai

Luo

et al. 2010

Bone Marrow Transplant

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This study aimed to analyze the association between cytokine gene polymorphisms and outcome following allogeneic hematopoietic SCT (allo-HSCT). A total of 138 unrelated donor/recipient pairs who underwent allo-HSCT from 2001 to 2009 were tested for TNFA-1031 (T4C), -863 (C4A), -857 (C4T), -238 (G4A), TNFB þ 252 (A4G) and TNFRII codon 196 (T4G) single nucleotide polymorphisms by multiplex SnaPshot analysis. Transplantation involving recipients and/or donors with TNFA-857 C/C genotype or TNFB þ 252 G allele-positivity resulted in a higher incidence of acute GVHD (aGVHD), which was independent of HLA mismatching. In multivariate analysis, TNFA-857 C/C genotype donors (relative risk (RR) ¼ 2.29, P ¼ 0.006) and TNFB þ 252 G allele-positive recipients (RR ¼ 1.789, P ¼ 0.036) were found to be significantly associated with an increased incidence of aGVHD. TNFA-857 C/C genotype donors (RR ¼ 3.748, P ¼ 0.002) and TNFB þ 252 G allele-positive recipients (RR ¼ 1.823, P ¼ 0.063) were also associated with the development of grades II-IV aGVHD. TNFRII polymorphism in recipients was also related to relapse rate, but no significant associations were found between TNFA, TNFB or TNFRII 196 genotype and cGVHD, relapse or overall survival after transplantation. These results provide the first report of an association between TNFA, TNFB and TNFRII polymorphic features and outcome of allo-HSCT in a Chinese population, and suggest an interaction between TNFA-857 and TNFB þ 252 genotypes and risk of aGVHD.

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Association of single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer risk in Indian population

Abstract: TNF-LTA locus could serve as an important biomarker for breast cancer predisposition in Indian population.

Cited by 54 publications

References 44 publications

Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis

Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis

The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population

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