Association of skin test reactivity, specific IgE, total IgE, and eosinophils with nasal symptoms in a community-based population study+

Droste, J. H. J.; Kerkhof, Marjan; Demonchy, Jgr; Schouten, JP; Rijcken, B

doi:10.1016/s0091-6749(96)80066-2

Cited by 135 publications

(84 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Questions on respiratory symptoms, such as current wheezing, were derived from the validated ECRHS questionnaire, and self-reported wheeze and shortness of breath have been shown to be independent predictors for pulmonary obstruction in dust-exposed workers in the Netherlands [34]. In the present study and in other Dutch populations, it has been demonstrated that self-reported allergy and hay fever were strongly associated with atopy, as assessed by skin-prick tests or specific IgE against common allergens [35,36].…”

Section: Endotoxin Exposure and Symptoms In Adults Lam Smit Et Almentioning

confidence: 62%

Exposure–response analysis of allergy and respiratory symptoms in endotoxin-exposed adults

Smit¹,

Heederik²,

Doekes³

et al. 2008

Eur Respir J

103

130

View full text Add to dashboard Cite

The objective of the present study was to investigate exposure-response relationships between current endotoxin exposure and allergic and respiratory symptoms in adults, taking into account farming exposures during childhood.A cross-sectional study was conducted among 877 Dutch farmers and agricultural industry workers in 2006. Based on 249 full-shift personal airborne endotoxin samples, a job-exposure matrix was constructed to assign endotoxin exposure levels to all participants. Associations between endotoxin exposure and questionnaire data on symptoms were studied by multiple logistic regression.Adjusted odds ratios (OR) for an interquartile range increase in endotoxin level were elevated for respiratory symptoms such as wheezing (OR 1.41 (95% confidence interval 1.16-1.72)), wheezing with shortness of breath (1.50 (1.18-1.90)) and daily cough (1.29 (1.03-1.62)). In contrast, endotoxin was strongly associated with a decreased prevalence of hay fever (0.62 (0.49-0.78)). Workers who had grown up on a farm had a lower prevalence of hay fever, but no evidence was found of effect modification by farm childhood.In conclusion, occupational endotoxin exposure in adulthood is associated with an increased risk of asthma-like symptoms but a reduced prevalence of hay fever.

show abstract

Section: Endotoxin Exposure and Symptoms In Adults Lam Smit Et Almentioning

confidence: 62%

Exposure–response analysis of allergy and respiratory symptoms in endotoxin-exposed adults

Smit¹,

Heederik²,

Doekes³

et al. 2008

Eur Respir J

103

130

View full text Add to dashboard Cite

show abstract

“…In a cross-sectional study no associations were observed between any n-3 and n-6 PUFA in serum phospholipids and allergic sensitisation in young adults as assessed by skin-prick test (Woods et al, 2004). The latter and specific IgE measurement may be considered complementary to one another (Droste et al, 1996). Using data from the Second National Health and Nutrition Survey (USA), even a positive association between fish intake as a source of n-3 PUFA and wheezing was observed among adults (Schwartz & Weiss, 1990).…”

Section: Discussionmentioning

confidence: 96%

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

et al. 2005

View full text Add to dashboard Cite

Objective: Due to inconsistent results based on dietary intake data, unsaturated fatty acids in red blood cell (RBC) membranes and diet were used to investigate their association with allergic sensitisation and allergic rhinitis. Design: Cross-sectional, population-based study. Setting: Bavarian Nutrition Survey II (2002-03), Germany. Subjects: A total of 568 adult participants, 325 women and 243 men. Methods: By means of logistic regression models, the relation of fatty acids to (i) allergic sensitisation as defined by means of specific serum immunoglobulin E analysis (CAPSX1 class Z2), and (ii) self-reported allergic rhinitis was examined. Results: A high cell membrane level of eicosapentaenoic acid (EPA, 20:5 n-3) was inversely associated with allergic sensitisation, the adjusted odds ratio (OR) and 95% confidence interval (95% CI) were 0.52 (0.30-0.90) for the highest (vs lowest) quartile. A similar effect was observed for allergic rhinitis with an OR (95% CI) of 0.50 (0.24-1.03; P ¼ 0.027 for trend). A higher dietary intake of alpha-linolenic acid (ALA, 18:3 n-3) was associated with a decreased risk of allergic sensitisation and allergic rhinitis with ORs (95% CIs) of 0.51 (0.28-0.93) and 0.43 (0.20-0.93), respectively, in the highest quartiles. No other dietary or cell membrane unsaturated fatty acid was significantly associated with the outcome variables, nor was the n-6/n-3 ratio. The strongest effects were observed among subjects under the age of 40 y. Conclusions: In this cross-sectional study among adults, a high content of n-3 fatty acids in RBC membranes (EPA) or in the diet (ALA) is associated with a decreased risk of allergic sensitisation and allergic rhinitis. Sponsorship: The study was supported by funds of the Kurt-Eberhard-Bode-Stiftung and the Bavarian Ministry of Environment, Health and Consumer Protection.

show abstract

“…Furthermore, we found that the relationship between total serum IgE levels and skin-prick test positive reactions varies with the specific categories of allergens: it is significant for house-dust mites and pollens, whilst it is not significant for moulds and animal danders. Therefore, both biomarkers of atopy should be used in epidemiological studies [30].…”

Section: Discussionmentioning

confidence: 99%

The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

Sapigni¹,

Biavati²,

Simoni³

et al. 1998

Eur Respir J

View full text Add to dashboard Cite

The purpose of the present study was to analyse whether sex, age, skin test reactivity, cigarette smoking and occupational exposure were related to the total serum immunoglobulin (Ig)E concentrations (kU x L[-1]), in a general population sample. We studied 1,905 subjects (915 males, 990 females) of a general population sample (n=2,841, 8-73 yrs) participating in the second cross-sectional respiratory epidemiological survey in the rural Po Delta area (near Venice, North Italy). Distribution of total serum IgE concentrations was skewed, thus a log-transformation was performed to obtain a Gaussian shape. Significantly higher values of IgE were found in males compared to females. In general, a peak of IgE concentration was found at 8-14 yrs. IgE values tended to be lower in older than younger adults. Significantly higher serum IgE levels were shown in subjects with a positive skin-prick test index (ST+) than in those with a negative skin-prick test index (ST-). There was a significant relationship of total IgE levels with skin reactivity to pollens and house-dust mites. In both sexes higher values of IgE were found in current smokers than in ex-nonsmokers, regardless of skin-test reactivity. There was no significant difference in IgE values between ex- and nonsmokers. Passive smoking and occupational exposure were significantly related to increased IgE values. Our results confirm that in a general population sample immunoglobulin E concentrations are related not only to skin-prick test reactivity to common aeroallergens, but also to other risk factors for chronic obstructive lung diseases, such as sex, active/ passive smoking and occupational exposure.

show abstract

Association of skin test reactivity, specific IgE, total IgE, and eosinophils with nasal symptoms in a community-based population study+

Cited by 135 publications

References 13 publications

Exposure–response analysis of allergy and respiratory symptoms in endotoxin-exposed adults

Exposure–response analysis of allergy and respiratory symptoms in endotoxin-exposed adults

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

Contact Info

Product

Resources

About