2021
DOI: 10.21203/rs.3.rs-264372/v1
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Association of Sleep Disturbances With Longitudinal Cognitive Decline Among Cognitively Normal Elders

Abstract: Background: A lot of evidence demonstrated sleep disturbances (SD) gets associated with Alzheimer’s disease (AD), but whether or not sleep disturbances could be the preclinical stage of AD is still unknown.Objective: 463 cognitively normal elders (357 normal and 106 SD) in baseline with cognitive and biomarker data were included in the study. Participants were collected from 2005 to 2020 (16 years follow-up) in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The generalized linear mixed models adjustin… Show more

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