Association of sleep duration and quality with elevated hs-CRP among healthy Korean adults

Abstract

This study aimed to investigate the association of sleep duration and quality with high-sensitivity C-reactive protein (hs-CRP) among middle-aged and elderly Koreans. Among a total of 74,867 participants (25,069 men and 49,798 women) recruited for the Health Examinees (HEXA) study, adjusted geometric means of hs-CRP level were compared across categories of sleep duration (<6, 6-7, 8-9, and �10 hours) and sleep quality (difficulty in initiating sleep and maintaining sleep) using ANCOVA models. Odds ratios (ORs) and 95% confidence intervals (CIs) for elevated hs-CRP (>3 mg/L) associated with sleep characteristics were estimated using multivariable-adjusted logistic regression models. Men who slept �10 hours per day were significantly associated with elevated hs-CRP (OR = 1.47, 95% CI 1.11-1.95). Whereas in women, difficulty in initiating sleep (OR = 1.28, 95% CI 1.04-1.57 for "Always"), and maintaining sleep was significantly associated with elevated hs-CRP levels (OR = 1.13, 95% CI 1.02-1.26 for "Often"; OR = 1.11, 95% CI 0.97-1.28 for "Always"). Additionally, women who experienced poor sleep quality presented an elevated level of hs-CRP (OR = 1.13, 95% CI 1.03-1.23). Our findings suggest that excessive sleep duration and poor sleep quality are significantly associated with the elevated inflammatory marker, specifically hs-CRP. Further research is needed to examine the effect of sleep interventions focused on these factors.

Examining the role of systemic chronic inflammation in diet and sleep relationship

“…In the current study, we observed associations with between better sleep and lower counts of platelets, CRP levels and NLR. Our findings extend the evidence form previous research showing negative associations with CRP levels and (i) sleep duration ( Ferrie et al, 2013 ) and sleep quality ( Lee et al, 2020 ; Liu et al, 2014 ). To the best of our knowledge, the current study is the first one to show associations of poor sleep quality (i.e.…”

“…Similarly, intervention studies found that long-term sleep restriction (5 days of restricted/shortened sleep, 4 h/night: 03.00–07.00 h) increased total white blood cell, monocytes, neutrophils and lymphocytes count ( Lasselin et al, 2015 ) and both acute total and short-term partial sleep deprivation increased CRP concentrations ( Meier-Ewert Hans et al, 2004 ). In terms of sleep quality, although there is some observational evidence showing associations between higher CRP levels and lower sleep quality ( Lee et al, 2020 ; Liu et al, 2014 ), research is limited for other SCI markers albeit suggestive of a similar relationship (e.g. Nishitani and Sakakibara, 2007 ; Obayashi et al, 2016 ).…”

Relationship between Poor Sleep Quality and High White Blood Cell Count in Korean Adults

“…Moreover, our results suggest that poor sleep quality is associated with a high WBC count, a test which is affordable, easy to interpret, and ordered routinely in clinical practice. A previous study revealed a relationship between sleep quality and CRP in Korean adults [8]. However, CRP, the inflammatory marker used in that study, is not routinely measured in clinical practice.…”

“…In addition, several studies have suggested that sleep quality can affect subclinical inflammation [6,7]. Although the exact mechanism between sleep and chronic low-grade inflammation is not fully understood, previous studies have shown that Relationship between Poor Sleep Quality and High White Blood Cell Count in Korean Adults greater sleep disturbance was associated with higher levels of some inflammatory markers, such as interleukin-6 (IL-6) and C-reactive protein (CRP) [8][9][10]. In addition, several studies have revealed that experimental sleep deprivation caused an increase in the natural production of tumor necrosis factor-α (TNF-α) and IL-6 in monocytes [11][12][13].…”

Association between sleep characteristics, ideal cardiovascular health, and systemic inflammation, NHANES 2017–2018

“…NHANES does not provide information on the actual diagnosis of OSA or treatment (e.g., use of continuous positive airway pressure), which has an unclear effect on systemic inflammation (Jullian‐Desayes et al, 2015). We were also unable to measure sleep quality, which is also associated with higher CRP (Lee et al, 2020). Future studies could use polysomnography or actigraphy, which would be more appropriate for larger community cohorts, to objectively quantify sleep quality and duration.…”