Association of sleep duration in middle and old age with incidence of dementia

Sabia, Séverine; Fayossé, Aurore; Dumurgier, Julien; Hees, Vincent T. van; Paquet, Claire; Sommerlad, Andrew; Kivimäki, Mika; Dugravot, Aline; Singh‐Manoux, Archana

doi:10.1038/s41467-021-22354-2

Cited by 362 publications

(244 citation statements)

References 52 publications

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“…Researchers recently analyzed 25 years of health data from nearly 8,000 middleaged people and found a link between sleep and dementia as people get older. Middle-aged people with long-term sleep less than or equal to 6 h have a 30% increased risk of dementia (Sabia et al, 2021). However, the current research on how sleep loss promote the occurrence of dementia is still insufficient.…”

Section: Introductionmentioning

confidence: 99%

Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis

Wang

Cao

et al. 2021

Front. Pharmacol.

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Objectives: Memory decline caused by insufficient sleep is a critical public health issues and currently lacks effective treatments. This study objective was to explore alleviative effect of melatonin on sleep deprivation (SD)-induced deficiencies in learning and memory.Materials and Methods: A continuous 72 h SD mouse model, with or without melatonin or Fer-1 supplementation were established. The changes of cognitive function, iron homeostasis, lipid peroxidation and intracellular signal pathways in mice were detected by Morris water maze, antioxidant assay, immunohistochemistry, western blot, RT-PCR and Prussian blue staining. In vitro, we treated HT-22 cells with ferroptosis inducer (Erastin) to further explore the specific mechanism of melatonin in ferroptosis.Results: Mice subjected to SD had significantly elevated latency and path length to reach hidden platform, as well as a decrease in number of entries and time spent in the target zone when the hidden platform was removed (p < 0.05). Nevertheless, supplementation with ferroptosis inhibitor (Fer-1) mitigated the memory impairment associated with SD. Further evaluation revealed an up-regulation of intracellular iron accumulation, transferrin receptor 1 and divalent metal transporter 1 expression and ROS and MDA production, and a down-regulation of ferroportin and antioxidant enzyme (GPX4 and SOD) expression in SD mice. SD decreased expression of MT2 receptor rather than of MT1, and inhibited ERK/Nrf2 signaling activation in the hippocampus (p < 0.05). In contrast, the aforementioned SD-inductions were reversed by supplementation using 20 and 40 mg/kg melatonin in SD mice. In vitro, melatonin pretreatment reversed Erastin-induced ferroptosis, abnormalities in iron transporter protein and antioxidant enzyme expression and suppression of ERK/Nrf2 signaling in HT-22 cells, however this protective effect of melatonin was blocked by MT2-, ERK- and Nrf2-specific antagonists (p < 0.05).Conclusion: Our finding suggested SD may induce ferroptosis, in turn leading to cognitive deficits. Melatonin alleviated memory loss and hippocampal ferroptosis caused by acute SD through binding to the MT2 receptor to activate ERK/Nrf2 signaling.

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Section: Introductionmentioning

confidence: 99%

Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis

Wang

Cao

et al. 2021

Front. Pharmacol.

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“…These studies and our findings indicate that, despite the undecided temporality of SMI and depressive symptoms, the presence or absence of depressive symptoms is the most significant variable differentiating older adults with or without SMI. Given that SMI [1,7,80] and depressive symptoms [81,82] are independent risk factors for MCI or Alzheimer's disease and that depressive symptoms and SMI are more prevalent generally among racial and ethnic minority elders [17,65,[83][84][85][86][87][88], the prevention and treatment of depression among racial and ethnic minority elders are critical for the prevention of cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

“…For the interaction analysis, depressive symptom scores were categorized into minimal (0–4), mild (5–9), and moderate/severe (10 or higher), and sleep hours were divided into two categories (less than 6 h and 6 or more hours). The literature suggests that a sleep duration of 6 h or less is associated with an increased incidence of dementia later in life [ 65 ]. SPSS version 25 was used to conduct all analyses.…”

Section: Methodsmentioning

confidence: 99%

Differences in Subjective Memory Impairment, Depressive Symptoms, Sleep, and Physical Activity in African American and Asian American Elderly

Lee

Nam

et al. 2021

Brain Sciences

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Background: Subjective memory impairment (SMI) is associated with negative health outcomes including mild cognitive impairment and Alzheimer’s disease. However, ethnic differences in SMI and disparities in risk factors associated with SMI among minority populations are understudied. The study examined the ethnic differences in SMI, whether SMI was associated with depressive symptoms, sleep, and physical activity (PA), and whether the associations vary across racial/ethnic groups. Methods: Participants included 243 African and Asian Americans (including Chinese, Vietnamese, and Korean Americans) aged 50 or older. Demographic information, SMI, depressive symptoms, daily sleeping hours, and PA levels were assessed. Results: Vietnamese Americans reported the highest SMI score. Depressive symptoms, sleeping hours, and PA levels were significantly associated with SMI. Depressive symptoms were the only significant factor across all ethnic groups. Significant interaction effects were found between ethnicity and health behaviors in predicting SMI. In particular, Vietnamese American participants with greater depressive symptoms and physical inactivity were significantly more likely to experience SMI compared to other ethnic groups Conclusions: Our findings demonstrate ethnic differences in SMI and its association with depressive symptoms, sleep, and PA, which highlight the importance of considering the unique cultural and historical backgrounds across different racial/ethnic groups when examining cognitive functioning in elderly.

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“…Short sleeping time is often associated with impaired performance in memory tasks (Mantua and Simonelli, 2019); in addition, the relationship between sleep, cognitive deficit, and the prevalence of AD has been confirmed by a meta-analysis (Bubu et al, 2017). A study of nearly 8,000 people found that those who consistently got 6 h of sleep or less per night during 25 years from their 50 s to 60 s were 30 percent more likely to develop dementia later in life, compared with those who slept 7 h per night (Sabia et al, 2021).…”

Section: The Cognitive Cost Of Sleep Restrictionmentioning

confidence: 93%

Metabolic Disturbances Induced by Sleep Restriction as Potential Triggers for Alzheimer’s Disease

García‐Aviles

Méndez‐Hernández

Guzmán-Ruiz

et al. 2021

Front. Integr. Neurosci.

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Sleep has a major role in learning, memory consolidation, and metabolic function. Although it is known that sleep restriction increases the accumulation of amyloid β peptide (Aβ) and the risk to develop Alzheimer’s disease (AD), the mechanism behind these effects remains unknown. In this review, we discuss how chronic sleep restriction induces metabolic and cognitive impairments that could result in the development of AD in late life. Here, we integrate evidence regarding mechanisms whereby metabolic signaling becomes disturbed after short or chronic sleep restriction in the context of cognitive impairment, particularly in the accumulation of Aβ in the brain. We also discuss the role of the blood-brain barrier in sleep restriction with an emphasis on the transport of metabolic signals into the brain and Aβ clearance. This review presents the unexplored possibility that the alteration of peripheral metabolic signals induced by sleep restriction, especially insulin resistance, is responsible for cognitive deficit and, subsequently, implicated in AD development.

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Association of sleep duration in middle and old age with incidence of dementia

Cited by 362 publications

References 52 publications

Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis

Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis

Differences in Subjective Memory Impairment, Depressive Symptoms, Sleep, and Physical Activity in African American and Asian American Elderly

Metabolic Disturbances Induced by Sleep Restriction as Potential Triggers for Alzheimer’s Disease

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