Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis

Kuang, Linghan; Zhou, Wei; Jiang, Yongmei

doi:10.1371/journal.pone.0260479

Cited by 12 publications

(9 citation statements)

References 59 publications

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“…As such, liver damage has been found to correlate with the severity of gut dysbiosis [102]. Since a diseased liver cannot effectively remove harmful products from the blood or inhibit the overgrowth of bacteria [103][104][105], this process can accelerate microbiota-gut-brain axis dysregulation and ultimately cognitive decline. Thus, when considering the occurrence of cognitive decline associated with microbial-derived metabolites, the role and function of the liver cannot be ignored.…”

Section: The Microbiota-gut-liver-brain Axismentioning

confidence: 99%

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell

Gall

Pontifex

et al. 2022

Mol Neurodegeneration

106

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A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identifying risk factors associated with cognitive decline becomes increasingly vital. Novel perspectives suggest that a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, commonly referred to as the microbiota-gut-brain axis, may be a contributing factor for cognitive health and disease. However, the exact mechanisms remain undefined. Microbial-derived metabolites produced in the gut can cross the intestinal epithelial barrier, enter systemic circulation and trigger physiological responses both directly and indirectly affecting the central nervous system and its functions. Dysregulation of this system (i.e., dysbiosis) can modulate cytotoxic metabolite production, promote neuroinflammation and negatively impact cognition. In this review, we explore critical connections between microbial-derived metabolites (secondary bile acids, trimethylamine-N-oxide (TMAO), tryptophan derivatives and others) and their influence upon cognitive function and neurodegenerative disorders, with a particular interest in their less-explored role as risk factors of cognitive decline.

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Section: The Microbiota-gut-liver-brain Axismentioning

confidence: 99%

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell

Gall

Pontifex

et al. 2022

Mol Neurodegeneration

106

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“…A complicating feature for the diagnosis is that these risk factors often appear in other diseases, making SIBO intertwined with other pathologies among which gastroenterological disorders (e.g. inflammatory bowel disease, irritable bowel syndrome, SBS, nonalcoholic fatty liver disease, cirrhosis, diabetes, and cystic fibrosis (Ierardi et al 2016 , Rafiei et al 2018 , Ricci et al 2018 , Fitriakusumah et al 2019 , Ghosh and Jesudian 2019 , Wu et al 2019 , Phyo et al 2021 , Shah 2021 , Feng and Li 2022 , Ghoshal et al 2022 ), and other nongastrointestinal (or indirectly linked) diseases such as Parkinson’s and Alzheimer’s disease (Kuang et al 2021 , Kowalski and Mulak 2022 ).…”

Section: Disruption Of Small Intestinal Homeostasis In Nutrient Balancementioning

confidence: 99%

The small intestine: dining table of host–microbiota meetings

Delbaere

Roegiers

Bron

et al. 2023

FEMS Microbiology Reviews

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Growing evidence suggests the importance of the small intestinal bacteria in the diet-host-microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly explored and its ecology and mechanisms of interaction with the host are just starting to be unraveled. In this review, we describe the current knowledge on the small intestinal ecology, its composition and diversity, and how the intestinal bacteria in homeostatic conditions participate in nutrient digestion and absorption. We illustrate the importance of a controlled bacterial density and of the preservation of absorptive surface for the host's nutritional status. In particular, we discuss these aspects of the small intestinal environment in the framework of two disease conditions, namely small intestinal bacterial overgrowth (SIBO) and short bowel syndrome (SBS). We also detail in vivo, ex vivo and in vitro models developed to simulate the small intestinal environment, some applied for (diet-)host-bacteria interaction studies. Lastly, we highlight recent technological, medical and scientific advances applicable to investigate this complex and yet understudied body environment to broaden our knowledge in support of further progress in the medical practice, and to proceed towards the integration of the (small)intestinal bacteria in personalized therapeutic approaches.

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“…This association was observed in meta-analysis conducted by Wijarnpreecha et al [44]. In another meta-analysis 3 studies were included, which reported that children with SIBO were more likely to have NAFLD [45]. There is also an inverse relationshipincreased prevalence of SIBO is observed in patients with NAFLD [8].…”

Section: Sportsmentioning

confidence: 77%

Gut microbiome in non-alcoholic fatty liver disease

Boryczka

Kosiorowska

Świętek

et al. 2022

Pol J Public Health

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The human gut microbiome is composed of communities of bacteria, viruses and fungi. Bacteria live in each part of digestive tract, increasing their density and changing composition in distal parts. The composition of gut microbiome mainly depends on method of childbirth, age, gender, diet, stress, infections, alcohol intake, diurnal variation, smoking, drugs (antibiotics), physical activity. Dysbiosis is defined as an imbalance or maladaptation in the gut microbial community. This imbalance favors many pathological states and it could be due to some diseases. Non-alcoholic fatty liver disease (NAFLD) has become increasingly common in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome. In year 2020, a more comprehensive new definition of NAFLD was proposed – fatty liver disease associated with metabolic dysfunction (MAFLD). NAFLD/MALFD will become the major form of chronic liver disease in adults and children and could become the leading indication for liver transplantation within a decade. An increased level of Bacteroidetes and decreased level of Firmicutes is observed in fatty liver disease. This imbalance favors the collection of energy and insulin resistance. The prevention and treatment of dysbiosis in NAFLD/MAFLD is essential. The purpose of this review is an understanding related to the dysbiosis and non-alcoholic fatty liver disease in order to help physicians of different specialties in their clinical practice because of growing in population patients with metabolic syndrome and liver steatosis.

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Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis

Cited by 12 publications

References 59 publications

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

The small intestine: dining table of host–microbiota meetings

Gut microbiome in non-alcoholic fatty liver disease

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