Association of smoking with anal high-risk HPV infection and histologically confirmed anal high-grade squamous intraepithelial lesions among a clinic-based population in Puerto Rico

Keller, Kandyce; Ramos-Cartagena, Jeslie M.; Guiot, Humberto M.; Muñoz, Cristina; Rodríguez, Yolanda; Colón‐López, Vivian; Deshmukh, Ashish A.; Tírado-Gómez, Maribel; Ortiz, Professor Ana Patricia

doi:10.1016/j.ctarc.2021.100503

Cited by 8 publications

(12 citation statements)

References 31 publications

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“…37 The association between smoking and anal HSIL was previously well-documented. 27 , 33 However, in our study no association was observed between smoking and anal HSIL among men living with HIV (p > 0.05). A recent study using data from the ANC reported a significant association between current smoking and anal HSIL after adjusting by age, sexual risk group, HIV status, lifetime number of sexual partners, and anal HR-HPV infection.…”

Section: Discussioncontrasting

confidence: 77%

“…However, studies have reported that sexually transmitted infections (STIs) such as chlamydia and gonorrhoea increased the risk of anal squamous intraepithelial lesions 28 and anal cancer. 33 Moreover, McCloskey et al reported that the seropositivity for HIV, HSV-2, T. pallidum , HBV, and HCV and history of gonorrhoea or chlamydia exert a powerful amplifying factor increasing the risk of anal HSIL above the risk of HR-HPV infection alone in both HIV-positive and HIV-negative patients. 34 While the association of HR-HPV infection and anal HSIL was marginally significant for both men and women living with HIV in our study (p > 0.05), others have reported a significant association between these variables, but when the HPV genotype has been considered, the fraction of anal cancer attributable to HPV-16 is smaller in the HPV-positive population.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Development of a multivariable prediction model for anal high-grade squamous intraepithelial lesions in persons living with HIV in Puerto Rico: a cross-sectional study

Soto-Salgado

Suárez

Viera-Rojas³

et al. 2023

The Lancet Regional Health - Americas

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Development of a multivariable prediction model for anal high-grade squamous intraepithelial lesions in persons living with HIV in Puerto Rico: a cross-sectional study

Soto-Salgado

Suárez

Viera-Rojas³

et al. 2023

The Lancet Regional Health - Americas

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“…5 Risk factors for SCCA include HIV infection, particularly advanced disease (ie, AIDS), and current smoking. [6][7][8][9][10] HIV-/AIDS-related immunosuppression enhances the carcinogenicity of HPV, causing an elevated SCCA risk. 8 Smoking impairs immune function, prohibiting the ability to clear HPV infection.…”

Section: Introductionmentioning

confidence: 99%

State Variation in Squamous Cell Carcinoma of the Anus Incidence and Mortality, and Association With HIV/AIDS and Smoking in the United States

Damgacioğlu

Lin

Ortiz

et al. 2023

JCO

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PURPOSE Squamous cell carcinoma of the anus (SCCA) incidence and mortality rates are rising in the United States. Understanding state-level incidence and mortality patterns and associations with smoking and AIDS prevalence (key risk factors) could help unravel disparities and provide etiologic clues. METHODS Using the US Cancer Statistics and the National Center for Health Statistics data sets, we estimated state-level SCCA incidence and mortality rates. Rate ratios (RRs) were calculated to compare incidence and mortality in 2014-2018 versus 2001-2005. The correlations between SCCA incidence with current smoking (from the Behavioral Risk Factor Surveillance System) and AIDS (from the HIV Surveillance system) prevalence were evaluated using Spearman's rank correlation coefficient. RESULTS Nationally, SCCA incidence and mortality rates (per 100,000) increased among men (incidence, 2.29-3.36, mortality, 0.46-0.74) and women (incidence, 3.88-6.30, mortality, 0.65-1.02) age ≥ 50 years, but decreased among men age < 50 years and were stable among similar-aged women. In state-level analysis, a marked increase in incidence (≥ 1.5-fold for men and ≥ two-fold for women) and mortality (≥ two-fold) for persons age ≥ 50 years was largely concentrated in the Midwestern and Southeastern states. State-level SCCA incidence rates in recent years (2014-2018) among men were correlated ( r = 0.47, P < .001) with state-level AIDS prevalence patterns. For women, a correlation was observed between state-level SCCA incidence rates and smoking prevalence ( r = 0.49, P < .001). CONCLUSION During 2001-2005 to 2014-2018, SCCA incidence and mortality nearly doubled among men and women age ≥ 50 years living in Midwest and Southeast. State variation in AIDS and smoking patterns may explain variation in SCCA incidence. Improved and targeted prevention is needed to combat the rise in SCCA incidence and mitigate magnifying geographic disparities.

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“…Previous studies provided added evidence to the association between smoking history [17], numbers of sexual partners [18], and contraception methods [19] with HPV infection, and accordingly with reinfection or regression. To rule out these biases, we controlled and subsequently excluded cases with specific identifications before or during the trial.…”

Section: Discussionmentioning

confidence: 99%

Gym-based aerobic exercise with bicycle ergometer contributes to the regression of human papilloma virus infection: a single-center, single-blind and randomized controlled trial

2022

European Journal of Gynaecological Oncology

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The regression of human papilloma virus is multifactorial and could be possibly targeted by using life-mode form of intervention. The purpose of this trial is to clarify the effect of aerobic exercise on the regression in outpatients firstly diagnosed with human papilloma virus(HPV) infection. Patients were randomly allocated into exercise group (Arm A) and control group (Arm B). Patients in Arm A received the 45-minute aerobic exercise thrice per week using the bicycle ergometer at gym. Patients in Arm B received their usual care at home. The physical exercise spanned a period of 6 weeks. The characteristics at baseline were documented and HPV specimens were tested at initiation, three months and six months after project launching. The primary endpoint was current HPV infection incidents as well as stratified by age at 3-months and 6-months. The secondary endpoint was newly diagnosed HPV incidents.In total, 125 patients in arm A and 136 patients in arm B were enrolled. The mean follow-up period was 7.5 ± 1.5 months (range 6.0–9.2). Post physical training, no significant difference of HPV 16/18 in groups was observed at 3-months or 6-months. As to current rate, physical exercise was superior to the patients with non-16/18 high-risk human papilloma virus(HR-HPV) infections at 6-months (p = 0.01). Stratified by age, the strength was still strong regarding age span of 18–25 years, 30–35 years, 35–45 years (p = 0.02, p = 0.04, p = 0.01, respectively). Additionally, the newly diagnosed HPV infection (HPV16/18 excluded) significantly decreased from 29 (21.3%) in Arm B to 14 (11.2%) in Arm A (p = 0.02). The current trail indicates that the 6-week aerobic exercise positively affects the regression of HPV infection, especially regarding the non-16/18 HPV infection.

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Association of smoking with anal high-risk HPV infection and histologically confirmed anal high-grade squamous intraepithelial lesions among a clinic-based population in Puerto Rico

Cited by 8 publications

References 31 publications

Development of a multivariable prediction model for anal high-grade squamous intraepithelial lesions in persons living with HIV in Puerto Rico: a cross-sectional study

Development of a multivariable prediction model for anal high-grade squamous intraepithelial lesions in persons living with HIV in Puerto Rico: a cross-sectional study

State Variation in Squamous Cell Carcinoma of the Anus Incidence and Mortality, and Association With HIV/AIDS and Smoking in the United States

Gym-based aerobic exercise with bicycle ergometer contributes to the regression of human papilloma virus infection: a single-center, single-blind and randomized controlled trial

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