Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes

Munshi, Anjana; Roy, Sitara; Thangaraj, Kumarasamy; Kaul, Subash; Babu, M. Sai; Jyothy, A.

doi:10.1016/j.gene.2012.06.079

Cited by 18 publications

(10 citation statements)

References 30 publications

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“…Whereas, in the latter study SNP41 and 56 were found to be associated with IS and its subtypes intracranial large artery, lacunar and cardioembolic stroke. This study also reported a novel SNP at position 59736747 T>G, however, analysis for this SNP did not report any significant association with IS [30,13]. Kalita et al (2011) on the other hand studied SNP32, 83 and 87 among North Indians and found frequency of CC genotype of SNP83 to be significantly more among IS patients.…”

Section: Case-control Studiescontrasting

confidence: 55%

“…Among Russians Avdonina et al (2012) evaluated association for 10 SNPs in different genes including PDE4D but could not establish any significant difference between patients and controls for any of the genes [29]. Our group evaluated the association of SNPs 32, 83, 87, 41 and 56 with IS and its subtypes in a South Indian population from Andhra Pradesh (Munshi et al 2009(Munshi et al , 2012. In the former study SNP83 was found to be associated with IS and its subtype intracranial large artery, extracranial large artery and lacunar stroke.…”

Section: Case-control Studiesmentioning

confidence: 97%

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Association between PDE4D gene and ischemic stroke: recent advancements

Das

Roy

Munshi

2015

International Journal of Neuroscience

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Stroke is a severe complication and a leading cause of death worldwide and genetic studies among different ethnicities has provided the basis for involvement of phosphodiesterase 4D (PDE4D) gene in cerebrovascular diseases. Recent advancements have evaluated the role of this gene in stroke and these studies have provided a stronger support for the involvement of this gene in stroke development and few studies also suggest that it may influence outcome. Furthermore, case-control studies and meta-analysis studies have provided strong evidence for certain variants in PDE4D to predispose to stroke only among certain ethnicities. Thus, this review focuses on recent progress made in PDE4D gene research involving genetic, molecular and pharmacological aspect. A strong conclusion has emerged that clearly indicates a pivotal role played by this gene in ischemic stroke globally. Studies have also noticeably highlighted that PDE4D gene/pathway can be a suitable drug target for managing stroke; however, a more comprehensive research is still required to understand the molecular and cellular intricacies this gene plays in stroke development, progression and its outcome.

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Section: Case-control Studiescontrasting

confidence: 55%

Section: Case-control Studiesmentioning

confidence: 97%

Association between PDE4D gene and ischemic stroke: recent advancements

Das

Roy

Munshi

2015

International Journal of Neuroscience

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“…However SNPs 37 and 87 were found to be monomorphic in our population. [45,46] Another study by Banerjee et al from India have also confirmed the association of SNP83 with ischemic stroke. A study from North India also found an association of SNP83 and SNP87 with ischemic stroke and extracranial large artery atherosclerosis respectively.…”

Section: Genes Involved In Endothelial Dysfunctionmentioning

confidence: 79%

Genetics of ischemic stroke

Kaul

Munshi

2012

Neurology India

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“…Lövkvist et al (9) performed a multi-center study involving a large sample of 2,599 patients with ischemic stroke and 2,093 control subjects from the south and west regions of Sweden and did not identify any correlation between the examined subgroups and SNP45 with ischemic stroke. Munshi et al (21) demonstrated a significant correlation of SNP56 and SNP41 with large artery atherosclerosis, and lacunar and cardioembolic stroke in the South Indian population from Andhra Pradesh. Furthermore, Matsushita et al (10) studied 5 SNPs in the Japanese population; however, no correlation was revealed between PDE4D gene polymorphisms and ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the single nucleotide polymorphisms of the human phosphodiesterase 4D gene and the risk of cerebral infarction in the Uygur and Han ethnic groups of Xinjiang, China

Sun

Zhang

et al. 2013

Experimental and Therapeutic Medicine

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In this study, the correlation between the single nucleotide polymorphisms (SNPs) at rs2910829 and rs918592 in the phosphodiesterase 4D (PDE4D) gene and cerebral infarction in the Uygur and Han ethnic groups of Xinjiang, China were examined. The study population consisted of 373 Uygur and Han patients with cerebral infarction and 377 Uygur and Han control participants with no nervous system diseases. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and gene sequencing methods were used to assess the SNPs at the rs2910829 and rs918592 loci in the PDE4D gene. The differences in genotype and allele frequency distribution were compared between the two groups. The C allele frequency of the rs2910829 locus in the PDE4D gene of the cerebral infarction group (81.0%) was significantly higher than that of the control group (76.4%) (P<0.05). Furthermore, the A allele frequency of the rs918592 locus in the PDE4D gene in the Uygur cerebral infarction group was significantly higher than that of the Uygur control group (P<0.05). There were no significant differences in the genotype and allele frequency distributions between the Uygur and Han groups (P>0.05). The A allele of the rs918592 locus may be associated with the occurrence of cerebral infarction in the Uygur population. In addition, it was indicated that the C allele of the rs2910829 locus in the PDE4D gene confers susceptibility to cerebral infarction; however, no significant difference was identified between Uygur and Han patients with cerebral infarction.

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Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes

Cited by 18 publications

References 30 publications

Association between PDE4D gene and ischemic stroke: recent advancements

Association between PDE4D gene and ischemic stroke: recent advancements

Genetics of ischemic stroke

Correlation between the single nucleotide polymorphisms of the human phosphodiesterase 4D gene and the risk of cerebral infarction in the Uygur and Han ethnic groups of Xinjiang, China

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