Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy

Abstract

This systematic review and meta-analysis investigates 4 studies for the association of sodium thiosulfate with reduced risk of ototoxic effects among patients treated with platinum-induced chemotherapy.

Prevention and treatment of cisplatin‐induced ototoxicity in adults: A systematic review

“…These results are similar to what has been found in high‐quality RCT in the paediatric population, where sodium thiosulphate reduced the incidence of cisplatin‐induced hearing loss among children with standard‐risk hepatoblastoma, without jeopardising overall or event‐free survival 48 . A recent systematic review and meta‐analysis, based on four studies with mixed paediatric and adult populations, confirms the otoprotective effect of sodium thiosulphate 49 . The remaining interventions have several limitations to consider that cannot be overlooked.…”

“…48 A recent systematic review and meta-analysis, based on four studies with mixed paediatric and adult populations, confirms the otoprotective effect of sodium thiosulphate. 49 The remaining interventions have several limitations to consider that cannot be overlooked. For instance, a considerable number and severity of side effects were reported in the intratympanic corticoids trial, a single trial was conducted with sertraline and statins, and the statins trial had a heterogeneous intervention, which limits the robustness of these results.…”

Global burden of ototoxic hearing loss associated with platinum-based cancer treatment: A systematic review and meta-analysis

“…Another option is pharmaceutical prevention via otoprotectants (e.g., sodium thiosulfate, amifostine), which may be co-administered with cisplatin to inhibit cell death pathways or augment protective pathways [98] . Despite a large body of evidence on otoprotectants [4] , [99] , [100] , some of which show promising effects in clinical trials [101] , [102] , most otoprotectants are not approved by international drug regulation agencies (e.g., food and drug administration) nor are they globally accessible. There is an urgent need for continued research to improve understanding on biological mechanisms of ototoxicity, which will progress the ability to identify and/or maximize effectiveness of pharmaceutical otoprotectants and to prioritize bringing these otoprotectants to market [103] .…”

Prevention and treatment of platinum ototoxicity in adults: A systematic review

“…These results are similar to what has been found in high-quality RCT in the pediatric population, where sodium thiosulfate reduced the incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival (Brock et al, 2018). A recent systematic review and meta-analysis, based on four studies with mixed pediatric and adult populations, confirms the otoprotective effect of sodium thiosulfate (Chen et al, 2021). On the other hand, the two non-pharmacological interventions that showed positive results were multivitamins and D-methionine.…”