Association of sperm source with miscarriage and take‐home baby after ICSI in cryptozoospermia: a meta‐analysis of testicular and ejaculated sperm

Ku, Fang-Yu; Wu, Chieh-Chen; Hsiao, Yu Cheng; Kang, Yi No

doi:10.1111/andr.12546

Cited by 21 publications

(18 citation statements)

References 23 publications

(78 reference statements)

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“…The primary design was registered on PROSPERO (CRD42018118063). The research team involved a neurologist, an anesthesiologist, and an experienced researcher in systematic review and meta-analysis [75,76,77]. The neurologist and anesthesiologist also have experience on conducting systematic reviews and meta-analyses [78,79].…”

Section: Methodsmentioning

confidence: 99%

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Huang

Lin

et al. 2019

IJMS

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We aimed to evaluate the response rate of migraines by using anti-calcitonin gene-related peptide (anti-CGRP) for patients with migraines. We searched three main medical databases up to 29 March 2019. No restriction on language and publication time were applied. Eligible trials included randomized clinical trials investigating a 50%, 75%, and 100% response rate of migraine patients after anti-CGRP intervention. The collected data were dichotomous, and risk ratios (RRs) with a 95% confidence interval (CI) were used to present the quantitative synthesis results. The systematic review identified 16 eligible randomized clinical trials (RCTs) with 9439 patients. Eight of the 16 trials with 2516 patients reported a 50% response rate, and the pooled results showed a significant benefit from anti-CGRP. However, the effects seem to gradually reduce from the first month (RR 1.99, 95% CI 1.59 to 2.49) to the third month (RR 1.48, 95% CI 1.26 to 1.75) of treatment. The magnitude of effect was influenced by the type of anti-CGRP, according to the test for differences between subgroups (I-square = 53%). The funnel plots and Egger’s tests did not show serious small study effects in the results. In conclusion, the current evidences confirmed that anti-CGRP treatment can reduce migraine pain in the short term (within three months), but the long-term effect should be investigated in the future. Moreover, its effects may be influenced by the type and dose of anti-CGRP. Therefore, future studies should make direct comparisons among anti-CGRP medications.

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Section: Methodsmentioning

confidence: 99%

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Huang

Lin

et al. 2019

IJMS

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“…In addition, maternal age is an important factor in human reproduction, so we also conducted subgroup analyses according to maternal mean age. Based on available data and previous work (13,14), we used <30 years old, 30-35 years old, and >35 years old for subgroup stratification.…”

Section: Discussionmentioning

confidence: 99%

“…To clarify the effect of sperm aspiration technique on miscarriage, we further stratified data by number of ICSI cycles because there appears to be a cumulative increase in risk (14).…”

Section: Discussionmentioning

confidence: 99%

Testicular versus percutaneous epididymal sperm aspiration for patients with obstructive azoospermia: a systematic review and meta-analysis

Shih¹,

Shen²,

Wu³

et al. 2019

Transl Androl Urol

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Background: Intracytoplasmic sperm injection (ICSI) is a popular treatment for male infertility due to obstructive azoospermia (OA). Testicular sperm aspiration (TESA) and percutaneous epididymal sperm aspiration (PESA) are two common sperm retrieval approaches for ICSI among men with OA. However, the comparative efficacies of TESA and PESA have been debated for more than a decade and there has been no synthesis of the available evidence. This meta-analysis compared fertility outcomes between TESA and PESA among men with OA undergoing ICSI.Methods: We searched Embase, PubMed, ScienceDirect, and Web of Science to identify studies comparing the effectiveness of TESA and PESA for ICSI. Study quality was assessed using the Newcastle-Ottawa scale. Data were pooled using a random-effects model. Outcomes were fertilization rate, implantation rate, pregnancy rate, and miscarriage rate. Results are expressed as odds ratio (OR) with 95% confidence intervals (CIs). Study heterogeneity was evaluated by the I-square (I 2 ) statistic.Results: Of 2,965 references retrieved, eight studies met eligibility criteria. These studies included 2,020 men receiving 2,060 ICSI cycles. The pooled results showed no significant differences in pregnancy and miscarriage rates between TESA and PESA groups, but TESA yielded a significantly higher implantation rate than PESA (OR =1.58, P=0.02, I 2 =24%).Conclusions: TESA and PESA yielded similar pregnancy and miscarriage rates for couples receiving ICSI because of OA, but each demonstrated unique advantages and disadvantages. Further studies are required to evaluate safety outcomes and efficacy for specific clinical groups.

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“…The authors showed that sperm retrieval and Testi-ICSI improved the likelihood of achieving good-quality embryos (RR = 1.17, 95% CI 1.05 to 1.30, P = 0.005), implantation (RR = 1.52, 95% CI 1.02 to 2.26, P = 0.04), and pregnancy (RR = 1.74, 95% CI 1.20 to 2.52, P = 0.004). These results were corroborated by Ku et al ., who pooled the evidence of studies that provided miscarriage and live birth data 44 . The authors included a total of 331 patients and 479 ICSI cycles.…”

Section: Severe Oligozoospermia and Cryptozoospermiamentioning

confidence: 99%

Extended indications for sperm retrieval: summary of current literature

Esteves¹,

Roque

2019

F1000Res

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Sperm retrieval combined with intracytoplasmic sperm injection (ICSI) is the treatment of choice for couples with untreatable azoospermia-related infertility. However, an increasing body of evidence has been mounting, suggesting that ICSI with testicular sperm instead of ejaculated sperm (when both are available) increases pregnancy outcomes in some specific scenarios. This has led to the exploration of extended indications for sperm retrieval. This review summarizes the current literature concerning sperm retrieval and ICSI for non-azoospermic men with elevated sperm DNA fragmentation, oligozoospermia, and cryptozoospermia.

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Association of sperm source with miscarriage and take‐home baby after ICSI in cryptozoospermia: a meta‐analysis of testicular and ejaculated sperm

Abstract: Comparing to ejaculated sperm, testicular sperm showed benefits for take-home baby rate, but not for miscarriage in patients with cryptozoospermia.

Cited by 21 publications

References 23 publications

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Testicular versus percutaneous epididymal sperm aspiration for patients with obstructive azoospermia: a systematic review and meta-analysis

Extended indications for sperm retrieval: summary of current literature

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