Association of Squamous Cell Carcinoma of lower lip with Xeroderma Pigmentosa – A Devastating disease

Tadke, Kanchan; Lahane, Dr.Vaibhav J.; Golhar, Sanjeev V.

doi:10.9790/0853-1601082023

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…SCC is the most reported type of malignancy affecting the oral mucosa in patients with XP (Figure 4a,b). 17,19–48 In fact, 93 mucosal SCCs have been reported in 130 pediatric XP patients. The most common sites were the tongue (43/93, 46.2%) and lips (34/93, 36.6%).…”

Section: Resultsmentioning

confidence: 99%

“…Specifically, one limbal SCC and one pigmented mass in limbus, 29,47 two melanomas on medial canthus 21 and conjunctiva, 22 and multiple SCCs on the conjunctiva 17,42,46,76 have been reported in pediatric XP patients. The majority of XP patients with oral mucosal lesions included in this review (110/130, 84.6%) also exhibited ocular findings, such as keratitis, blindness, and symblepharon 17–19,21–24,29–31,40,41,43,45–48,67 . It is worth noting that our literature review focused exclusively on oral mucosal findings in pediatric patients and did not include a specific search for other mucosal areas, such as the genital mucosa or ocular areas.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of XP patients with oral mucosal lesions included in this review (110/ 130, 84.6%) also exhibited ocular findings, such as keratitis, blindness, and symblepharon. [17][18][19][21][22][23][24][29][30][31]40,41,43,[45][46][47][48]67 It is worth noting that our literature review focused exclusively on oral mucosal findings in pediatric patients and did not include a specific search for other mucosal areas, such as the genital mucosa or ocular areas.…”

Section: Non-tumoral Lesionsmentioning

confidence: 99%

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Oral mucosa involvement in pediatric patients with xeroderma pigmentosum: a comprehensive review

Baskurt,

Vural,

Ertekin

et al. 2023

Int J Dermatology

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BackgroundXeroderma pigmentosum (XP) is a rare autosomal recessive disorder presenting with an inability to repair UV‐induced DNA damage. This can lead to the development of neoplasms affecting multiple organ systems, with onset often in childhood. Unfortunately, no cure currently exists for XP, and management strategies focus on sun protection and early intervention for malignancies. Although most skin problems in XP patients are UV induced, various oral lesions are also described. However, the literature has not extensively characterized the oral manifestations and their prognostic significance.MethodsWe conducted a comprehensive review to evaluate the prevalence and nature of oral mucosal lesions in pediatric XP patients.ResultsOur literature search yielded 130 pediatric XP patients with oral involvement and 210 associated tumoral or non‐tumoral lesions. Squamous cell carcinoma was the most common type of oral mucosal tumor reported, with other malignancies including basal cell carcinoma, melanoma, angiosarcoma, fibrosarcoma, and trichilemmal carcinoma.ConclusionGiven the potential morbidity and mortality associated with oral mucosal tumors in XP patients, our study aims to raise awareness of these manifestations. Early diagnosis and treatment are crucial for managing these lesions effectively, and routine oral exams should be considered a critical component of dermatological evaluations for XP patients, especially in the pediatric age group.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Non-tumoral Lesionsmentioning

confidence: 99%

See 1 more Smart Citation

Oral mucosa involvement in pediatric patients with xeroderma pigmentosum: a comprehensive review

Baskurt,

Vural,

Ertekin

et al. 2023

Int J Dermatology

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A short review on DNA damage and repair effects in lip cancer

Toprani

Mane²

2021

Hematology/Oncology and Stem Cell Therapy

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Increasing trend in oral cancer (0.6% per year) and its related mortality has been reported worldwide since 2010. The United States alone reports an increase of 57% within the past 10 years. This emphasizes the need not only for designing strategies of prevention and planning but also for an effective treatment regime for the various oral cancers. Cancers of the lips, tongue, cheeks, floor of the mouth, and hard palate have been primarily classified under the category of oral cancers. If left undiagnosed, these cancers can be life threatening. Amongst these, the most undesignated and understudied cancer type is the lip carcinoma, which is either categorized under oral cancer or/as well as skin cancer or head and neck cancer. However, lip cancer corresponds to 25–30% of all diagnosed oral cancers. Though the etiology of lip cancer is not yet fully understood, numerous risk factors involved in its development are now being studied. The cells in the lip region are continuously exposed to various DNA damaging agents from endogenous as well as exogenous sources. Flaws in DNA repair mechanisms involved in eliminating these damages may be linked to the origin of carcinogenesis. Accumulation of DNA damage and defect in repair mechanisms may play a role in lip carcinogenesis and progression. This literature review is an exhaustive compilation of the research work performed on the role of DNA damage and repair responses in lip carcinoma which will pave a path for researchers to identify predictive DNA repair biomarker/s for lip cancer, and its diagnosis, prevention, and treatment.

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Xeroderma pigmentosum variant: squamous cell carcinoma of the lower lip harboring exon 11 mutation of POLH

Pereira¹,

Castro²,

Menck³

et al. 2021

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Association of Squamous Cell Carcinoma of lower lip with Xeroderma Pigmentosa – A Devastating disease

Cited by 3 publications

References 5 publications

Oral mucosa involvement in pediatric patients with xeroderma pigmentosum: a comprehensive review

Oral mucosa involvement in pediatric patients with xeroderma pigmentosum: a comprehensive review

A short review on DNA damage and repair effects in lip cancer

Xeroderma pigmentosum variant: squamous cell carcinoma of the lower lip harboring exon 11 mutation of POLH

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