Association of Statin Therapy With Prevention of Vision-Threatening Diabetic Retinopathy

Kang, Eugene Yu-Chuan; Chen, Tien-Hsing; Garg, Sunir J.; Sun, Chi-Chin; Kang, Je-Ho; Wu, Wei‐Chi; Hung, Ming‐Jui; Lai, Chi-Chun; Cherng, Wen‐Jin; Hwang, Yih‐Shiou

doi:10.1001/jamaophthalmol.2018.6399

Cited by 87 publications

(69 citation statements)

References 36 publications

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“…In the FIELD study, lipid-lowering therapy was associated with a reduced risk of lower-limb amputations, suggesting that lipid lowering may have beneficial effects on diabetic neuropathy [61]. In the aforementioned study of more than 18,000 individuals with type 2 diabetes from Taiwan, statin therapy significantly reduced the risk of new-onset diabetic neuropathy and foot ulcers [51]. While the mechanisms involved are not fully understood, oxidised LDL-cholesterol induced oxidative stress has been shown to mediate nerve damage in a mouse model of dyslipidaemia-induced neuropathy [62] and likely plays a similar role in neural injury in diabetic neuropathy [13].…”

Section: Rise Of the Role Of Lipid Metabolism In Diabetic Complicationsmentioning

confidence: 99%

“…Several small uncontrolled studies examining the effects of statin use on diabetic retinopathy risk found a beneficial effect [47,48] but were contradicted by larger studies [49,50]. On the other hand, a recent well-conducted large study in Taiwan, of more than 18,000 individuals with type 2 diabetes with age and sexmatched controls, found that statin use significantly reduced retinopathy risk, diminished the incidence of macular oedema and reduced the need for further interventions [51]. Moreover, the FIELD and ACCORD Eye studies found that fenofibrate use significantly lowered the risk of diabetic retinopathy progression and/or the need for laser intervention in diabetic individuals [52,53].…”

Section: Rise Of the Role Of Lipid Metabolism In Diabetic Complicationsmentioning

confidence: 99%

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New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

et al. 2019

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Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both type 1 and type 2 diabetes, tissue damage is organ specific and is secondary to a combination of multiple metabolic insults. Hyperglycaemia, dyslipidaemia and hypertension combine with the duration and type of diabetes to define the distinct pathophysiology underlying diabetic kidney disease, diabetic retinopathy and diabetic neuropathy. Only recently have the commonalities and differences in the metabolic basis of these tissue-specific complications, particularly those involving local and systemic lipids, been systematically examined. This review focuses on recent progress made using preclinical models and human-based approaches towards understanding how bioenergetics and metabolomic profiles contribute to diabetic kidney disease, diabetic retinopathy and diabetic neuropathy. This new understanding of the biology of complication-prone tissues highlights the need for organ-specific interventions in the treatment of diabetic complications.

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Section: Rise Of the Role Of Lipid Metabolism In Diabetic Complicationsmentioning

confidence: 99%

Section: Rise Of the Role Of Lipid Metabolism In Diabetic Complicationsmentioning

confidence: 99%

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

et al. 2019

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“…There are no obvious early symptoms in diabetic retinopathy [2]; hence, when visual problems begin, retinopathy has already advanced to almost a point of no return [4]. Laser therapy is the mainly effective therapy for preservation of sight in proliferative retinopathy [5]; however, it is not effective for reversing visual loss [5]. DR is a progressive disease characterized by visible microvascular alterations, including retinal ischemia-reperfusion injury, inflammation, abnormal permeability, neovascularization and macular edema [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

p38 promoted retinal micro-angiogenesis through up-regulated RUNX1 expression in diabetic retinopathy

et al. 2020

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Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and is characterized by visible microvascular alterations including retinal ischemia–reperfusion injury, inflammation, abnormal permeability, neovascularization and macular edema. Despite the available treatments, some patients present late in the course of the disease when treatment is more difficult. Hence, it is crucial that the new targets are found and utilized in the clinical therapy of DR. In the present study, we constructed a DR animal model and a model in HRMECs to investigate the relationship between p38 and RUNX1 in retinal micro-angiogenesis in diabetic retinopathy. We found that p38 could promote retinal micro-angiogenesis by up-regulating RUNX1 expression in diabetic retinopathy. This suggested that the p38/ RUNX1 pathway could become a new retinal micro-angiogenesis target in DR treatment.

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“…It is induced by diabetes, which causes the pathology of retinal capillaries, arterioles and venules, and the subsequent effects of leakage from or occlusion of small vessels [22–24]. Laser therapy is the mainly effective therapy for preservation of sight in proliferative retinopathy [24]; however, it is poor to reverse visual loss. Hence, it is still to find the new therapies to improve the effective of DR.…”

Section: Discussionmentioning

confidence: 99%

ASK1/p38-mediated NLRP3 inflammasome signaling pathway contributed to aberrant retinal angiogenesis in diabetic retinopathy

Zhou¹,

Zhang²,

Luo³

et al. 2019

Preprint

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Abstracts: Diabetic retinopathy is the leading cause of blindness in the working-age 18 population in many countries. Despite the available treatments, some patients present 19 late in the course of the disease when treatment is more difficult. Hence, it is crucial 20 that the new targets are found and utilized in clinical therapy of diabetic retinopathy. 21In this study, we constructed the DR animal model and the high model in HRMEC 22 cell to investigate the relationship between ASK1/p38 and NLRP3 in DR. The results 23 showed that DR could cause the inflammatory response and microvascular 24 proliferation. NLRP3 contributed to DR-mediated inflammatory development and 25 progression, which promoted the inflammatory related cytokine expression. 26 Meanwhile, it could promote the tube formation of retinal microvascular endothelial 27 and angiogenesis. Moreover, further research showed that NLRP3 mediated aberrant 28 retinal angiogenesis in diabetic retinopathy was regulated by ASK1 and p38. It 29 suggested that ASK1/p38 could become a new target in DR treatment.30

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Association of Statin Therapy With Prevention of Vision-Threatening Diabetic Retinopathy

Cited by 87 publications

References 36 publications

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

p38 promoted retinal micro-angiogenesis through up-regulated RUNX1 expression in diabetic retinopathy

ASK1/p38-mediated NLRP3 inflammasome signaling pathway contributed to aberrant retinal angiogenesis in diabetic retinopathy

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