Association of Statin Use and Reduced Risk of Lower-Extremity Amputation Among Patients With Diabetes: A Nationwide Population-Based Cohort Observation

Yang, Tsung‐Lin; Lin, Liang Yu; Huang, Chin Chou; Huang, Po Hsun; Lin, Shing Jong; Chen, Jaw Wen; Chan, Wan Leong; Leu, Hsin Bang

doi:10.2337/dc15-2376

Cited by 7 publications

(3 citation statements)

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“…Statins have been shown to decrease the progression of peripheral arterial disease, improving symptoms and reducing amputations. 80 Because persons with T2D and HF often have dyslipidemia as a comorbid condition, it is important they are educated and made aware that adhering to the prescribed lipid-lowering therapy reduces their risk for developing progressive peripheral arterial disease and other associated vascular complications.…”

Section: Discussionmentioning

confidence: 99%

Correlates of Self-Care Behaviors in Adults With Type 2 Diabetes and Comorbid Heart Failure

et al. 2019

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Heart failure (HF) is a comorbidity that complicates type 2 diabetes mellitus (T2D) management and increases the chance of death. However, little is known concerning factors related to diabetes self‐efficacy in comorbid HF. This secondary data analysis was aimed at describing sociodemographic and clinical correlates of diabetes self‐efficacy in adults with T2D and comorbid HF. A correlational design was used to analyze cross‐sectional baseline data from a randomized study of 180 participants that tested a 6‐month integrated self‐care intervention targeting adults with concomitant HF and T2D. Participants were enrolled from one of four large urban‐tertiary hospitals in Atlanta, GA, during 2010–2013. Data were collected from medical records and self‐report. We used stepwise multiple linear regressions to examine variables associated with diabetes self‐efficacy. The participants' mean age was 58.1 ± 10.7 years and the majority were male (n = 118; 65.6%) and African American (n = 119; 66.1%). Good self‐rated health and presence of implantable cardioverter‐defibrillator (ICD) had significant positive relationships with diabetes self‐efficacy, while taking both oral antiglycemic medication and insulin, history of depression, cardiac pacemaker, and taking digitalis were negatively related. These variables collectively explained 22.4% of the variation in diabetes self‐efficacy. One study implication is that using self‐rated health provides a quick, patient‐centered assessment to evaluate patient health status. Further studies are warranted to ascertain the pathways linking ICD, pacemaker, and digitalis treatment with diabetes self‐efficacy.

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Section: Discussionmentioning

confidence: 99%

Correlates of Self-Care Behaviors in Adults With Type 2 Diabetes and Comorbid Heart Failure

et al. 2019

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“…In Taiwan, a population-based cohort study examined the effect of statin use on lower extremity amputation after diabetic foot infection and found 52% of the 38,793 patients with diabetes were prescribed a statin. Compared to patients not prescribed a statin, a significant 52% risk reduction in lower-extremity amputations was observed ( p < 0.01) [28].…”

Section: Discussionmentioning

confidence: 99%

Statin Use and the Point Prevalence of Antibiotics in Ambulatory Patients with Diabetes in the National Health and Nutrition Examination Survey (NHANES) 2003–2012

2019

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In patients with diabetes, the risk of infections is increased, hypothesized to be due to alterations in the immune system, among other changes. The pleotropic effects of statins have been investigated to assess their role in reducing the risk of infection and infection-related outcomes with varying results. The aim of this study is to determine if the use of statins is associated with a decrease in the point prevalence of oral antibiotic use in ambulatory patients with diabetes. Using data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2012, all adult patients diagnosed with diabetes were analyzed. Patients were grouped into those who were prescribed statins and those who were not. Oral antibiotic use between the two groups was compared. Data were standardized to national estimates. A total of 3240 patients with diabetes were identified, with 1575 statin users and 1665 non-statin users. After controlling for baseline socio-demographic and clinical variables, the overall point prevalence of oral antibiotic use in diabetes population was 3.5% with no difference between statin users and non-statin users (2.9% vs. 4%, p = 0.116). Based on the results of this study, the use of statins in patients with diabetes was not associated with a reduction in the point prevalence of antibiotic use.

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“…A megfelelő konzervatív kezelés hiánya több mint négyszeres kockázatot jelentett az alsó végtagi major amputáció vonatkozásában [48]. További olyan tényezők, amelyek nem az alsó végtagi revascularisatióval közvetlenül függnek össze és a klinikai tanulmányok alapján az alsó végtagi amputációk megelő-zésében jótékonynak bizonyultak: hemoglobin-A-1c-csökkentés [49], statinterápia [50], optimális gyógysze-res kezelés [48], dohányzás felfüggesztése [51], rendszeres alsó végtagi ellenőrzés [52], dialízisminőség [53], a beteg, illetve az ellátószemélyzet edukációja [54,55], betegút-optimalizálás [56], multidiszciplináris kezelés [57], egészségtudatosság szintjének növelése [55].…”

Section: Az Egészségügyi Ellátórendszer Szerepe Az Alsó Végtagi Amputunclassified

A perifériás verőérbetegséggel és a cukorbetegséggel összefüggő alsó végtagi amputációk. Epidemiológiai adatok bemutatása és a megelőző stratégia lehetőségeinek elemzése

Járai

Farkas

2016

Orvosi Hetilap

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Az alsó végtagi amputáció, mint a perifériás verőérbetegség és a cukorbetegség egyik legsúlyosabb következménye, kiemelt figyelmet érdemel. Az összefoglaló közlemény célja a magyar és a nemzetközi amputációs adatok összehason-lítása. Szembesülve azzal, hogy az előfordulásra, időbeni trendekre vonatkozó globális amputációs adatok rendkívül változékonyak, az összefoglaló elemzi a variabilitás lehetséges meghatározó jellemzőit. E faktorok közé tartoznak a tanulmányok közlési módjának különbözőségei, az érintett népesség demográfiai, epidemiológiai, gazdasági, társa-dalmi és kulturális tényezői, valamint az egészségügyi szolgáltatás minőségében tapasztalt eltérések. Az amputációs kockázat értelmezhető egyfajta élettartam-kockázatként, ami a különböző kockázati faktorok időben változó mintá-zatának eredménye. Ebben az értelemben a hatékony megelőző stratégiai tervezés összetett intézkedési lépéseket igényel, ami több tudományág kooperációját, időben elkezdett megelőző intézkedések kezdeményezését, valamint központosított érbetegellátás kialakítását feltételezi. Az alsó végtagi amputációkkal kapcsolatban a kutatás-fejlesztés egyértelmű prioritás, ami segíthet ennek a rendkívül összetett, kiemelt népegészségügyi jelentőséggel bíró kérdésnek a pontosabb megértésében. Orv. Hetil., 2016, 157(32), 1266-1274. Kulcsszavak: alsó végtagi amputáció, perifériás érbetegség, diabeteses láb Peripheral arterial disease and diabetes related lower limb amputations Presentation of the epidemiological data and the analysis of potentialities in preventive strategyLower limb amputation as one of the most devastating consequences of peripheral arterial disease and diabetes mellitus needs peculiar attention. This review aims at comparing Hungarian and international amputation data. Realizing the great variability of the global amputation incidence and trends data, the main determinants of this variety are assessed. These factors involve methodological differences in reporting, demographic, epidemiological, economic, societal and cultural variation of the affected populations and differences in the health care service. The amputation hazard can be considered as an example of lifetime risk that can be characterized by complex interaction of contionuously changing risk factor pattern. In that sense an effective preventive strategy planning needs complex measure implementations that associate with multidisciplinary approach, timely complex preventive interventions and centralized vascular care. Research and development on amputation field shows clear priority that can contribute to the better understanding of this extremely complex scenario with significant public health consequences. Keywords: lower limb amputation, peripheral arterial disease, diabetic footKolossváry, E., Járai, Z., Farkas, K. [Peripheral arterial disease and diabetes related lower limb amputations. Presentation of the epidemiological data and the analysis of potentialities in preventive strategy].

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Association of Statin Use and Reduced Risk of Lower-Extremity Amputation Among Patients With Diabetes: A Nationwide Population-Based Cohort Observation

Abstract: Figure 1-A: Cumulative incidence of amputation between statin and control groups. B: Relative hazard ratio of amputation stratified according to DM medications and statin use.care.diabetesjournals.org Yang and Associates e55

Cited by 7 publications

References 5 publications

Correlates of Self-Care Behaviors in Adults With Type 2 Diabetes and Comorbid Heart Failure

Correlates of Self-Care Behaviors in Adults With Type 2 Diabetes and Comorbid Heart Failure

Statin Use and the Point Prevalence of Antibiotics in Ambulatory Patients with Diabetes in the National Health and Nutrition Examination Survey (NHANES) 2003–2012

A perifériás verőérbetegséggel és a cukorbetegséggel összefüggő alsó végtagi amputációk. Epidemiológiai adatok bemutatása és a megelőző stratégia lehetőségeinek elemzése

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