Association of Subclinical Hearing Loss With Cognitive Performance

Golub, Justin S.; Brickman, Adam M.; Ciarleglio, Adam; Schupf, Nicole; Luchsinger, José A.

doi:10.1001/jamaoto.2019.3375

Cited by 131 publications

(154 citation statements)

References 34 publications

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“…Although the majority of subjects had normal hearing, reflecting the community‐based middle age sample, associations between both hearing and cognition 27 as well as hearing and brain volumes 14 have been found previously in this age group. This argues against the need to oversample subjects with HL.…”

Section: Discussionsupporting

confidence: 51%

The Association Between Early Age‐Related Hearing Loss and Brain β‐Amyloid

et al. 2020

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Objectives/Hypothesis To analyze the association between early audiometric age‐related hearing loss and brain β‐amyloid, the pathologic hallmark of Alzheimer's disease (AD). Study Design Cross‐sectional analysis of a prospective cohort study. Methods A cross‐sectional analysis was performed on 98 participants in a cohort study of hearing and brain biomarkers of AD. The primary outcome was whole brain β‐amyloid standardized uptake value ratio (SUVR) on positron emission tomography (PET). The exposure was hearing, as measured by either pure‐tone average or word recognition score in the better ear. Covariates included age, gender, education, cardiovascular disease, and hearing aid use. Linear regression was performed to analyze the association between β‐amyloid and hearing, adjusting for potentially confounding covariates. Results The mean age ± standard deviation was 64.6 ± 3.5 years. In multivariable regression, adjusting for demographics, education, cardiovascular disease, and hearing aid use, whole brain β‐amyloid SUVR increased by 0.029 (95% confidence interval [CI]: 0.003‐0.056) for every 10 dB increase in pure‐tone average (P = .030). Similarly, whole brain β‐amyloid SUVR increased by 0.061 (95% CI: 0.009‐0.112) for every 10% increase in word recognition score (P = .012). Conclusions Worsening hearing was associated with higher β‐amyloid burden, a pathologic hallmark of AD, measured in vivo with PET scans. Level of Evidence 3 Laryngoscope, 131:633–638, 2021

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Section: Discussionsupporting

confidence: 51%

The Association Between Early Age‐Related Hearing Loss and Brain β‐Amyloid

et al. 2020

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“… 58 A cross-sectional study of 6451 individuals designed to be representative of the US population, with a mean age of 59·4 years, found a decrease in cognition with every 10 dB reduction in hearing, which continued to below the clinical threshold so that subclinical levels of hearing impairment (below 25 dB) were significantly related to lower cognition. 59 …”

Section: Specific Potentially Modifiable Risk Factors For Dementiamentioning

confidence: 99%

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

et al. 2020

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Prof J Cohen-Mansfield), and Minerva Center for Interdisciplinary Study of End of Life (Prof J Cohen-Mansfield),should consider dementia in older people without known dementia who have frequent admissions or who develop delirium. Delirium is common in people with dementia and contributes to cognitive decline. In hospital, care including appropriate sensory stimulation, ensuring fluid intake, and avoiding infections might reduce delirium incidence.Acting now on dementia prevention, intervention, and care will vastly improve living and dying for individuals with dementia and their families, and thus society.

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“…Previous work has shown similar relationships between hearing impairment and cognition when controlling for CVDR, but did not examine the plausible role of CVDR. Given that CVDR did not attenuate the relationships between hearing impairment and cognition, our results do not support a cardiovascular common cause of hearing impairment and cognitive impairment. However, longitudinal data are required to confirm, and our results do not rule out the possibility of an altogether different factor that effects CVDR, hearing impairment, and cognition (eg, genetics).…”

Section: Discussionmentioning

confidence: 99%

Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function

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Bainbridge

et al. 2021

JAMA Otolaryngol Head Neck Surg

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Key Points Question Is hearing impairment associated with cardiovascular disease risk and cognitive function among Hispanic or Latino participants? Findings In this cohort study of 9623 Hispanic/Latino adults, hearing impairment was associated with poorer cognitive performance on all tasks, and cardiovascular disease risk did not attenuate these relationships. Rather, hearing impairment modified the associations between cardiovascular disease risk and learning and memory; only among individuals with hearing impairment, being identified as having excessively high glucose was associated with poorer learning and memory relative to participants considered healthy individuals. Meaning Hearing impairment may exacerbate the associations between high glucose and poorer cognition, particularly for learning and memory among Hispanic or Latino persons.

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Association of Subclinical Hearing Loss With Cognitive Performance

Cited by 131 publications

References 34 publications

The Association Between Early Age‐Related Hearing Loss and Brain β‐Amyloid

The Association Between Early Age‐Related Hearing Loss and Brain β‐Amyloid

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function

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