Association of subclinical hypothyroidism and phenotype, insulin resistance, and lipid parameters in young women with polycystic ovary syndrome

Ganie, Mohd Ashraf; Laway, Bashir Ahmad; Wani, Tariq Ahmed; Zargar, Mohammad Afzal; Nisar, Shazia; Ahamed, Feroze; Khurana, Madan Lal; Ahmed, Sajjad

doi:10.1016/j.fertnstert.2011.01.149

Cited by 55 publications

(51 citation statements)

References 32 publications

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“…9 Ganie et al 2011 showed a higher prevalence of the PCOS phenotype in euthyroid adolescent girls with juvenile autoimmune thyroiditis, suggesting a possible role in the pathogenesis of the PCOS phenotype. 10 In the present study the frequency of raised TSH in PCOS were very few. We selected the PCOS patient from tertiary level hospital.…”

Section: Discussioncontrasting

confidence: 55%

Association of altered thyroid function and prolactin level in polycystic ovarian syndrome

et al. 2016

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Section: Discussioncontrasting

confidence: 55%

Association of altered thyroid function and prolactin level in polycystic ovarian syndrome

et al. 2016

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“…An analysis of results was possible in the case of total testosterone levels, which The LH/FSH ratio was reported by four studies. None of them reported significant differences (22,25,27,33). Finally, among the four studies that reported outcomes related to SHBG levels, only Dittrich reported that they were significantly reduced in the study group (33.65 ± 17.21 vs 43.55 ± 18.20 nmol/L, P = 0.01) (27,28,29,32).…”

Section: Hormonal Profilementioning

confidence: 90%

“…Twelve studies were finally included in the present review, which enrolled 2654 PCOS patients (22,23,24,25,26,27,28,29,30,31,32,33). Among them, 577 women had PCOS and SCH and the remaining 2077 had PCOS only.…”

Section: Included Studiesmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis

Pergialiotis

Konstantopoulos

Prodromidou

et al. 2017

European Journal of Endocrinology

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Objective: Subclinical hypothyroidism (SCH) is encountered in 10-25% of women with PCOS. To date, it remains unclear whether this coexistence influences the severity of metabolic and hormonal profile of these patients. The purpose of our systematic review is to investigate this potential relation. Methods: We systematically searched Medline, Scopus, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar databases together with reference lists from included studies. All prospective and retrospective observational cohort studies that investigated the impact of subclinical hypothyroidism on hormonal and metabolic parameters of PCOS patients were included. The methodological quality of studies was assessed with the Ottawa-Newcastle criteria. Statistical meta-analysis was performed with the RevMan 5.3 software. Results: Twelve studies were finally included in the present review, which enrolled 2341 PCOS patients. Among them, 577 had subclinical hypothyroidism, whereas the remaining 2077 were PCOS women with normal thyroid function. The presence of SCH significantly affected HDL (MD -3.92 mg/dL 95% CI: -6.56, -1.29) and triglycerides levels (26.91 mg/dL 95% CI: -3.79, 50.02). HOMA-IR was also affected (MD 0.82 95% CI: 0.15, 1.50). On the other hand, LDL, fasting glucose and 2-h OGTT were not influenced. Similarly, prolactin, FSH, LH, LH/FSH ratio and sex hormone-binding globulin remained unaffected. Conclusion: Subclinical hypothyroidism does not influence the hormonal profile of women with PCOS. On the other hand, it results in mild metabolic abnormalities, which are not clinically important in a short-term setting.

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“…[12][13][14] This clearly shows that hypothyroidism can cause metabolic derangements in PCOS subjects which can have an adverse effect. It is a well established fact that serum cholesterol levels are increased in patients with hypothyroidism and treatment of hypothyroidism will lead to lowering of serum cholesterol levels.…”

Section: Discussionmentioning

confidence: 89%

Coexisting hypothyroidism – Does it aggravate PCOS?

2020

IJCBR

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Introduction: The goal of the present study was to find out the effect of coexisting hypothyroidism on the biochemical and anthropometric measurements in PCOS patients. Materials and Methods:The study consisted of 90 subjects already diagnosed as PCOS and thirty age matched controls .Biochemical parameters like fasting blood sugar and lipid profile and the anthropometric measurements like BMI and waist circumference were compared between the two groups. The 90 PCOS subjects were further divided in to two depending on their thyroid status as euthyroid and hypothyroid and the biochemical and anthropometric parameters were compared between these two groups. Result: In our study there was no statistically significant difference in the biochemical parameters between the PCOS subjects and the control group but the anthropometric parameters BMI and waist circumference were markedly increased in PCOS subjects as compared to the control group. The fasting blood sugar, total cholesterol (TC), LDL cholesterol and TG (triglyceride) levels were increased in hypothyroid PCOS subjects as compared to the euthyroid PCOS subjects. The waist circumference was also markedly increased in hypothyroid PCOS subjects as compared to the euthyroid group. Conclusion: Fasting blood sugar, Total cholesterol, LDL cholesterol and triglycerides were significantly increased in hypothyroid PCOS patients as compared to euthyroid PCOS patients. This may increase the risk of developing diabetes and cardiovascular events in PCOS patients suffering form hypothyroidism

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Association of subclinical hypothyroidism and phenotype, insulin resistance, and lipid parameters in young women with polycystic ovary syndrome

Cited by 55 publications

References 32 publications

Association of altered thyroid function and prolactin level in polycystic ovarian syndrome

Association of altered thyroid function and prolactin level in polycystic ovarian syndrome

MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis

Coexisting hypothyroidism – Does it aggravate PCOS?

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