Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study

Peng, Pu; Wang, Qianjin; Zhou, Yanan; Hao, Yuzhu; Chen, Shubao; Wu, Qiuxia; Li, Manyun; Wang, Yunfei; Yang, Qian; Wang, Xin; Liu, Yueheng; Ma, Yuejiao; Xu, Huixue; Li, Zejun; Lang, Xiaoe; Liu, Tieqiao; Zhang, Xiangyang

doi:10.1007/s00406-023-01588-9

Eur Arch Psychiatry Clin Neurosci

2023

DOI: 10.1007/s00406-023-01588-9

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Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study

Pu Peng

Qianjin Wang

Yanan Zhou

et al.

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Cited by 7 publications

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“…Furthermore, thyroid dysfunction in MDD is closely linked to various clinical outcomes. These include metabolic disturbances, 5 an elevated risk of readmission 6 and more severe psychiatric symptoms. 7 The effectiveness of thyroid hormone therapy in treating depression, supported by several studies, 7 , 8 further highlights the critical role of thyroid function in the context of MDD.…”

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Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-naïve major depressive disorder and comorbid autoimmune thyroiditis

Luo,

Zhou,

Peng

et al. 2024

BJPsych open

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Background Autoimmune thyroiditis is closely associated with major depressive disorder (MDD) and suicide attempts. However, few studies have examined this relationship. Aims The study aimed to assess the prevalence and correlates of suicide attempts in patients with first-episode drug-naïve (FEDN) MDD and autoimmune thyroiditis. Method We recruited 1718 out-patients with FEDN MDD and assessed depressive, anxiety and psychotic symptoms with the Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety (HRSA) and Positive and Negative Syndrome Subscale positive subscale, respectively. The serum levels of free triiodothyronine, free thyroxine, thyroid stimulating hormone (TSH), antithyroglobulin, thyroid peroxidase antibody (TPOAb) and several other metabolic parameters were assessed. Patients were divided into non-autoimmune thyroiditis, autoimmune thyroiditis only and autoimmune thyroiditis with abnormal TSH groups, based on autoimmune thyroiditis severity. Multiple logistic regression model was applied to identify the correlates of suicide attempts in patients with MDD and autoimmune thyroiditis with abnormal TSH. Results Compared with the non-autoimmune thyroiditis group, the autoimmune thyroiditis with abnormal TSH group had a nearly fourfold higher likelihood of reporting a suicide attempt, whereas no difference was found between the non-autoimmune thyroiditis and autoimmune thyroiditis only groups. HRSA score, lnTPOAb and lnTSH were independently associated with suicide attempts in patients with autoimmune thyroiditis with abnormal TSH. Conclusions Patients with MDD and autoimmune thyroiditis with abnormal TSH are at higher risk for suicide attempt. TPOAb, TSH and anxiety are all independently associated with suicide attempts in this population, and regular thyroid checks are warranted.

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Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-naïve major depressive disorder and comorbid autoimmune thyroiditis

Luo,

Zhou,

Peng

et al. 2024

BJPsych open

Self Cite

View full text Add to dashboard Cite

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Suicidal ideation in Chinese patients with chronic schizophrenia: prevalence, clinical correlates, and relationship with alexithymia

Zhou,

Peng,

Yuan

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study

Peng,

Wang,

Wang

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study

Cited by 7 publications

References 52 publications

Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-naïve major depressive disorder and comorbid autoimmune thyroiditis

Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-naïve major depressive disorder and comorbid autoimmune thyroiditis

Suicidal ideation in Chinese patients with chronic schizophrenia: prevalence, clinical correlates, and relationship with alexithymia

Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study

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