Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease: a systematic review and meta-analysis

Asgari-Taee, Farzaneh; Zerafati-Shoae, Nahid; Dehghani, Mohsen; Sadeghi, Mahvash; Baradaran, Hamid Reza; Jazayeri, Shima

doi:10.1007/s00394-018-1711-4

Cited by 66 publications

(54 citation statements)

References 59 publications

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“…The main risk factors for primary NAFL and NAFLD ( Table 1 ) are overweight/obesity, insulin resistance/type 2 diabetes, hypertriglyceridaemia and the related dietary-behavioural triggers, primarily the intake of beverages sweetened with fructose. By itself, in different observational studies [ 5 ], only consumption of sugared soft drinks (mainly with fructose) increases the risk of developing NAFLD of around 55% [ 6 ]. Among the emerging risk factors there are also the smoking habit and the Obstructive Sleep Apnoea Syndrome (OSAS), but also insomnia and excessive daytime sleepiness unrelated to nocturnal sleep apnoea [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

2018

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Non-alcoholic fatty liver disease (NAFLD) is a clinical condition characterized by lipid infiltration of the liver, highly prevalent in the general population affecting 25% of adults, with a doubled prevalence in diabetic and obese patients. Almost 1/3 of NAFLD evolves in Non-Alcoholic SteatoHepatitis (NASH), and this can lead to fibrosis and cirrhosis of the liver. However, the main causes of mortality of patients with NAFLD are cardiovascular diseases. At present, there are no specific drugs approved on the market for the treatment of NAFLD, and the treatment is essentially based on optimization of lifestyle. However, some nutraceuticals could contribute to the improvement of lipid infiltration of the liver and of the related anthropometric, haemodynamic, and/or biochemical parameters. The aim of this paper is to review the available clinical data on the effect of nutraceuticals on NAFLD and NAFLD-related parameters. Relatively few nutraceutical molecules have been adequately studied for their effects on NAFLD. Among these, we have analysed in detail the effects of silymarin, vitamin E, vitamin D, polyunsaturated fatty acids of the omega-3 series, astaxanthin, coenzyme Q10, berberine, curcumin, resveratrol, extracts of Salvia milthiorriza, and probiotics. In conclusion, Silymarin, vitamin E and vitamin D, polyunsaturated fatty acids of the omega-3 series, coenzyme Q10, berberine and curcumin, if well dosed and administered for medium–long periods, and associated to lifestyle changes, could exert positive effects on NAFLD and NAFLD-related parameters.

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Section: Introductionmentioning

confidence: 99%

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

2018

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“…Previous studies have suggested that high intake of eicosapentaenoic acid and docosahexaenoic acid [42], magnesium [43], and vitamin C [44] is linked to low prevalence of fatty liver diseases. In contrast, consumption of refined carbohydrates may increase hepatic de novo lipogenesis and risk of fatty liver diseases [45]. Based on this existing knowledge, our finding that there were no notable differences before and after adjustment for dietary pattern scores indicates that dietary patterns may be confounding in both positive and negative ways, rather than dietary patterns not being a confounder.…”

Section: Discussionmentioning

confidence: 54%

Association of alcohol consumption with prevalence of fatty liver after adjustment for dietary patterns: Cross-sectional analysis of Japanese middle-aged adults

et al. 2020

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s u m m a r yBackground & aims: Moderate alcohol intake is associated with reduced prevalence or incidence of fatty liver. However, whether or not the association is independent of dietary patterns remains unclear. We aimed to evaluate the cross-sectional association of alcohol intake with fatty liver after accounting for dietary patterns and obesity. Methods: We assessed 4579 adults aged 30e79 years who participated in routine clinical examinations in St. Luke's International Hospital, Japan (January to March, 2015). We assessed their habitual diet using diet-history questionnaire, estimated alcohol intake, and derived dietary pattern variables using factor analysis. Fatty liver was ascertained using ultrasonography. Linear and U-shaped associations of alcohol intake with fatty liver were evaluated using Poisson regression, and a post hoc analysis was conducted after detecting potential outliers for alcohol intake and excluding them using sex-specific statistics (median plus 2 Â interquartile range). Results: Fatty liver was ascertained in 1120 participants (24.5%). Whereas no significant association of alcohol intake with fatty liver was observed when potential outliers of alcohol intake were included (p ¼ 0.25), a significant U-shaped association was observed after excluding the outliers with and without adjustment for dietary patterns (p ¼ 0.003 and 0.02, respectively). The lowest prevalence was estimated when alcohol consumption was approximately 7% of energy, with a prevalence ratio of 0.72 (95% confidence interval ¼ 0.59e0.86) compared to non-drinkers. The association became imprecise and attenuated toward the null after further adjustment for body mass index (p ¼ 0.06). Conclusions: Alcohol intake showed a U-shaped association with fatty liver prevalence. This association was independent of underlying dietary patterns, while it was sensitive to excessive alcohol intake and obesity status, providing clinical implications for the prevention of fatty liver.Abbreviations: BDHQ, brief-type self-administered diet history questionnaire; BMI, body mass index; CI, confidence interval; NAFLD, non-alcoholic fatty liver disease; PR, prevalence ratio; SD, standard deviation; %E, percentage of energy.

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“…The preservation of systemic insulin responsiveness (and glucose tolerance; Supplementary Figure 2) in our model demonstrate a clear decoupling of the mechanisms responsible for steatosis and those responsible for impairments in insulin sensitivity following chronic sucrose intake and, in the case of female mice, overt obesity ( Figure 1A). In humans, sugar sweetened beverage consumption is strongly associated with NAFLD (Arenaza et al, 2019;Asgari-Taee et al, 2019;Assy et al, 2008;Cahlin et al, 1973;Chen et al, 2019;Ma et al, 2015) but not always with obesity (Te Morenga et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Findings from observational studies and meta analyses indicate that excessive sugar intake or compromised sugar metabolism may be an initiating factor for NAFLD in humans (Arenaza et al, 2019;Asgari-Taee et al, 2019;Assy et al, 2008;Cahlin et al, 1973;Chen et al, 2019;Ma et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Chronic high dietary sucrose induces sexually dimorphic metabolic adaptations in liver and adipose tissue

Stephenson

Sethuraman

et al. 2020

Preprint

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Almost all effective treatments for non-alcoholic fatty liver disease (NAFLD) involve reduction of adiposity, which suggests the metabolic axis between liver and adipose tissue is essential to NAFLD development.Since excessive dietary sugar intake may be an initiating factor for NAFLD, we have characterized the metabolic effects of liquid sucrose intake at concentrations relevant to typical human consumption in mice. We report that sucrose intake induces sexually dimorphic effects in liver, adipose tissue, and the microbiome; differences concordant with steatosis severity. We show that when steatosis is decoupled from impairments in insulin responsiveness, sex is a moderating factor that influences sucrose-driven lipid storage and the contribution of de novo fatty acid synthesis to the overall hepatic triglyceride pool. Our findings provide physiologic insight into how sex influences the regulation of adipose-liver crosstalk and highlight the importance of extrahepatic metabolism in the pathogenesis of diet-induced steatosis and NAFLD.

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Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease: a systematic review and meta-analysis

Abstract: This meta-analysis supports a positive significant association between higher consumption of SSB and NAFLD in both men and women. These findings strengthen the evidence that intake of SSBs should be limited to reduce fatty liver disease.

Cited by 66 publications

References 59 publications

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Association of alcohol consumption with prevalence of fatty liver after adjustment for dietary patterns: Cross-sectional analysis of Japanese middle-aged adults

Chronic high dietary sucrose induces sexually dimorphic metabolic adaptations in liver and adipose tissue

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