Association of Superoxide Dismutase (SOD1) Gene Polymorphism with Oxidative Stress in PAHs Exposed Brick Kiln Workers in Haryana

Abstract

In developing countries like India brick kiln in suburban areas pose a major threat to environment and health of brick kiln workers and those who lives in close vicinity. Due to long working hours and lack of safety measures workers were exposed to various harmful pollutant like polycyclic aromatic hydrocarbons (PAHs). To assess the health risk of brick kiln workers due to PAHs exposure the present study was carried out on group of 100 PAH exposed brick kiln workers and 100 healthy individuals of Haryana. We have examined SOD enzyme activity and SOD1 A251G polymorphism against PAH induced oxidative stress in human population. From our result we have found significantly lower value of SOD enzyme in exposed workers and polymorphism SOD1 A251G also contributes significantly to its phenotype in exposed workers as compared to healthy control. Current study suggested high level of oxidative stress in brick kiln workers of Haryana due to long exposure to heat and PAHs compounds. Protective measure should be taken to prevent health risk.