Association of susceptibility to Takayasu arteritis in Chinese Han patients with HLA-DPB1

New Human Leukocyte Antigen Risk Allele in Japanese Patients With Takayasu Arteritis

“…[11][12][13][14] In the Japanese population, the HLA-B52 and -B39 haplotypes are closely associated with susceptibility to TA. 15, 16 In addition, it has been suggested that the presence of specific HLA-B alleles is related to clinical manifestations of TA.…”

HLA and SNP haplotype mapping in the Japanese population

“…The study elucidated detailed LD structures in this region and provided information about the correlation between HLA alleles and SNPs. However, in this study, the DPB1 locus, which is also reported to be associated with several immune-related diseases, [3][4][5][6][7][8][9] was not genotyped. Therefore, additional studies including DPB1 would provide more information in this research area.…”

Renal Vascular Disease

“…Also, there have not been any comparisons of outcome between different clinical presentations of ARVD. What is known is that adverse prognostic markers for mortality in ARVD include lower levels of baseline renal function (with marked increases in mortality where creatinine clearance, the forerunner of eGFR, at diagnosis is <25 ml/ min) [ 90 ], proteinuria in excess of 1 g/24 h [ 56 ], and extra-renal arterial disease (discussed next). Despite identifi cation of these risk factors, the direct mechanism by which ARVD increases risk for death is not defi ned.…”