Association of Sweet Taste Receptor Gene Polymorphisms with Dental Caries Experience in School Children

Haznedaroğlu, Eda; Koldemir-Gündüz, Meliha; Bakır-Coşkun, Nur; Bozkus, Hasan Mert; Çağatay, Penbe; Süsleyici-Duman, Belgin; Menteş, Ali

doi:10.1159/000381426

Cited by 48 publications

(52 citation statements)

References 49 publications

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“…Patients who are oversensitive may feel bitter or sweet taste more intensely, therefore they need a lower concentration of a substrate and, consequently, are less susceptible to caries [Darshana et al, 2014]. SNP of genes influencing taste reception, and thus carbohydrate metabolism, is a genetic factor in the aetiology of dental caries [Fushan et al, 2009;Wendell et al, 2010;Haznedaroğlu et al, 2015;Robino et al, 2015;Yildiz et al, 2016]. Hereditary fructose intolerance can lead to a variety of unpleasant symptoms, which occur in patients after its consumption.…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Turska‐Szybka²,

2017

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Recent progress in the field of molecular biology and techniques of DNA sequence analysis allowed determining the meaning of hereditary factors of many common human diseases. Studies of genetic mechanisms in the aetiology of caries encompass, primarily, 4 main groups of genes responsible for (1) the development of enamel, (2) formation and composition of saliva, (3) immunological responses, and (4) carbohydrate metabolism. The aim of this study was to present current knowledge about the influence of single nucleotide polymorphism (SNP) genetic variants on the occurrence of dental caries. PubMed/Medline, Embase, and Cochrane Library databases were searched for papers on the influence of genetic factors connected with SNP on the occurrence of dental caries in children, teenagers, and adults. Thirty original papers written in English were included in this review. Study groups ranged from 30 to 13,000 subjects. SNPs were observed in 30 genes. Results of the majority of studies confirm the participation of hereditary factors in the aetiology of caries. Three genes, AMELX, AQP5, and ESRRB, have the most promising evidence based on multiple replications and data, supporting a role of these genes in caries. The review of the literature proves that SNP is linked with the aetiology of dental caries.

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Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Turska‐Szybka²,

2017

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“…Recent genetic and genomic studies have reported that a number of genes are associated with the susceptibility to dental caries [Louropoulou et al, 2008;Katz et al, 2009;Letra et al, 2012a Yang et al, 2013;Wang et al, 2013;Karasneh et al, 2014;Zorina et al, 2014;Haznedaroğlu et al, 2015]. However, some of these studies could not be replicated for validation in different populations [Louropoulou et al, 2008;Yang et al, 2013].…”

Section: Discussionmentioning

confidence: 99%

Association of <b><i>MBL2</i></b> Gene Polymorphism with Dental Caries in Saudi Children

Alyousef¹,

Borgio

AbdulAzeez

et al. 2016

Caries Res

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The high prevalence of dental caries in children worldwide is a major oral health problem which requires early intervention. Dental caries is mainly caused by the action of acids produced by bacteria in addition to many other factors. Recent genetic studies have reported that a number of genes are associated with the susceptibility to dental caries. The majority of these genes are associated with inflammation, increased susceptibility to infection, and dentine matrix formation. Using the TaqMan assay and direct DNA sequencing, the prevalence of 6 single-nucleotide polymorphisms (SNPs) in MMP9, MBL2, MMP2, and TIMP2 genes was determined in 102 children with caries and in 100 age-matched caries-free controls. Out of the 6 SNPs tested in the 4 selected genes, only rs11003125 in the MBL2 gene was shown to be associated with a high prevalence of caries in our cohort. In addition, haplotype analysis of the 6 SNPs tested revealed that certain haplotypes, namely GT of rs11003125G and rs7501477T and GT of rs7096206G and rs7501477T, were found to be associated with a high prevalence of dental caries in our cohort, while haplotype AG of rs17576A and rs7501477G was found to have a protective effect against dental caries. In conclusion, the data indicate that rs11003125 in the MBL2 gene was shown to be associated with a high prevalence of caries in our cohort, and 2 haplotypes are also involved in the increased susceptibility to dental caries.

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“…Taste perception is believed to be influenced by cultural factors [Mennella et al, 2005]. Although not evaluated in the present study, it has previously been reported that sweet taste perception can be influenced by genetic factors [Haznedaroglu et al, 2015;Opal et al, 2015].…”

mentioning

confidence: 72%

“…Studies focusing on sweetness preference, sugar intake, and the levels of caries have been conducted in different countries [Jamel et al, 1997;Bretz et al, 2006;Robino et al, 2015]. Moreover, caries has been found to be associated with the sweet taste genetic factor [Haznedaroglu et al, 2015]. Genetic sensitivity to the bitter taste has been found to be related to caries experience [Rupesh and Nayak, 2006;Hedge and Sharma, 2008], and caries prevalence has been found to be higher in children of mothers who exhibit genetic taste sensitivity to sweet food [Alanzi et al, 2013].…”

mentioning

confidence: 99%

Sweet Taste Perception and Dental Caries in 13- to 15-Year-Olds: A Multicenter Cross-Sectional Study

Ashi¹,

Lara-Capi²,

Campus³

et al. 2017

Caries Res

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Dietary habits and, in particular, the intake frequency of sucrose are of major importance for the development of dental caries. The perception of sweet taste is believed to have an influence on sucrose intake and therefore affects the predisposition to dental caries. The aim was to study the caries experience and sweet taste perception and to further analyze the possible relationship between the 2 tested variables in 13- to 15-year-old children from 3 different geographical areas. A cross-sectional survey comprising 669 children (220 Italian, 224 Mexican, and 225 Saudi Arabian) was conducted. The children were examined in their school setting. A sweet taste perception level was determined by the sweet taste threshold (TT) and sweet taste preference (TP). The sweet test was performed with sucrose solutions varying in concentration from 1.63 to 821.52 g/L. The International Caries Detection and Assessment System (ICDAS) and DMFS indices were used to diagnose caries. The highest mean value for TT was found for Italian children followed by Saudi and Mexican. Saudi schoolchildren showed the highest mean values for TP and DMFS, followed by Italian and Mexican. A statistically significant difference for TP, TT, DMFS, and initial caries was found between the 3 countries. A weak yet positive correlation was found between taste perception (TT and TP) versus DMFS and manifest caries in all 3 countries (r = 0.137-0.313). The findings of the present study showed a variation in sweet taste perception between the 3 countries, which may influence the caries outcome of the children in the individual countries.

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Association of Sweet Taste Receptor Gene Polymorphisms with Dental Caries Experience in School Children

Cited by 48 publications

References 49 publications

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Association of <b><i>MBL2</i></b> Gene Polymorphism with Dental Caries in Saudi Children

Sweet Taste Perception and Dental Caries in 13- to 15-Year-Olds: A Multicenter Cross-Sectional Study

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