Association of sympathovagal imbalance with obesity indices, and abnormal metabolic biomarkers and cardiovascular parameters

Jagadeeswaran, Indumathy; Pal, G K; Pal, Pravati; Ananthanarayanan, Palghat Hariharan; Sc, Parija; Balachander, Jayaraman; Dutta, Tarun Kumar

doi:10.1016/j.orcp.2014.01.007

Cited by 39 publications

(40 citation statements)

References 43 publications

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“…Decreased parasympathetic activity in these subjects was further confirmed by the decrease in HFnu and the time domain indices (Mean RR, RMSSD, SDNN, NN50, and pNN50) of HRV, as reduction in these HRV indices reflects decreased vagal modulation of cardiac drive [28,48]. These findings are in conformity with the findings of our previous study that SVI in obesity is linked to the sympathetic activation and vagal withdrawal [9]. A similar alteration in autonomic balance is also seen in pre-obese subjects (Table 2).…”

Section: Parameterssupporting

confidence: 91%

“…Among the lipid risk factors, AI has been reported to be associated with SVI [9]. Thus, from the findings of the present study dyslipidemia could be the likely contributor to CV risks in both the groups (Table 4).…”

Section: Discussionsupporting

confidence: 62%

“…BMI was calculated using the formula weight in kilograms divided by square of height in meters. Obesity indices such as WHR and WHtR were also calculated as described previously [9].…”

Section: Obesity Indicesmentioning

confidence: 99%

“…Sympathovagal imbalance (SVI) has been reported to be closely associated with CV morbidity and mortality [7,8]. Recently, we have reported SVI in the form of increased sympathetic and decreased parasympathetic activity and reactivity in obese subjects and the link of SVI to hypertension status and CV risks in these subjects [9]. However, the pathophysiological mechanisms by which CV risks are increased in obese individual have not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Jagadeeswaran

Pal

et al. 2015

Metabolism

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Section: Parameterssupporting

confidence: 91%

Section: Discussionsupporting

confidence: 62%

“…BMI was calculated using the formula weight in kilograms divided by square of height in meters. Obesity indices such as WHR and WHtR were also calculated as described previously [9].…”

Section: Obesity Indicesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Jagadeeswaran

Pal

et al. 2015

Metabolism

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“…La relación entre enfermedades cardiovasculares y obesidad está ampliamente documentada y ha tratado de explicarse mediante varios mecanismos fisiopatológicos incluyendo resistencia a la insulina, hipertensión y dislipidemia. Sin embargo, también se ha sugerido que la desregulación en la función autonómica puede explicar la ocurrencia aumentada de enfermedad cardiovascular en personas con sobrepeso y obesidad 1 . La variabilidad de la frecuencia cardíaca permite medir el efecto de la función autonómica sobre el corazón.…”

Section: Introductionunclassified

¿Es la grasa abdominal subcutánea un predictor de la variabilidad cardíaca en hombres con bajo riesgo metabólico?

Avendaño

Urbina

2016

revsal

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341¿Es la grasa abdominal subcutánea un predictor de la variabilidad cardíaca en hombres con bajo riesgo metabólico?Is the abdominal subcutaneous fat a predictor of heart rate variability in men with low metabolic risk? RESUMENIntroducción: Aunque el sobrepeso/obesidad, adiposidad aumentada e inactividad física se asocian a menor variabilidad cardíaca y desregulación autonómica, no se ha explorado en detalle la relación entre estos factores en sujetos de bajo riesgo metabólico. Objetivo: Analizar el tipo y fuerza de asociación entre la variabilidad cardíaca en reposo y la adiposidad en hombres jóvenes, delgados y físicamente activos. Metodología: Estudio descriptivo transversal. Se analizaron los componentes espectrales de la variabilidad cardíaca en 24 hombres de 18-30 años físicamente activos, con peso y adiposidad normales. Se realizaron análisis de regresión lineal múltiple para explicar la variabilidad cardíaca en función de la relación cintura/cadera, pliegue abdominal y actividad física. Resultados: El volumen de actividad física semanal se relacionó positivamente con RMSSD y HF, y negativamente con LF y LF/HF. La relación cintura/cadera y el pliegue abdominal se relacionaron positivamente con HF y negativamente con LF y LF/HF. En todos los casos, los coeficientes de regresión β tipificados estuvieron entre 0,395 y 0,505 (p<0,05). El índice de grasa visceral calculado a partir de bioimpedancia no mostró relación alguna. Conclusiones: Los hallazgos aquí reportados son indicativos de que en hombres jóvenes, delgados y físicamente activos, la actividad física y la grasa subcutánea se relacionan positivamente con el tono vagal y negativamente con el tono simpático, lo que lleva a postular que la acumulación del exceso calórico en forma de tejido adiposo subcutáneo (y no visceral) podría ser un mecanismo de protección contra el desarrollo de síndrome metabólico en estos sujetos.Palabras clave: Frecuencia cardíaca, sistema nervioso parasimpático, distribución de la grasa corporal, grasa subcutánea abdominal, ejercicio, sistema nervioso autónomo.

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Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults

et al. 2016

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Purpose Obese adults exhibit increased levels of inflammation which may negatively affect blood pressure regulation. Based on existing literature, we hypothesized: 1) baroreflex sensitivity would be lower in obese adults when compared to lean adults, 2) acute ibuprofen (IBU, a cyclooxygenase inhibitor and nonsteroidal anti-inflammatory agent) administration would increase baroreflex sensitivity in obese adults, with no effect in lean adults. Methods Seven lean (4M, 3F) and six obese (5M, 1F) adults completed two visits randomized to control (CON) or IBU (800 mg oral). On each visit, blood pressure (intra-arterial catheter), heart rate (ECG), and muscle sympathetic nerve activity (MSNA, microneurography) were measured continuously. Sympathetic and cardiac baroreflex sensitivity were assessed using the modified Oxford technique. Results Measures of systemic inflammation [C-Reactive protein (CRP) and Interleukin-6 (IL-6)] were higher in obese adults when compared to lean adults, and tended to decrease with IBU (IL-6: p<0.05; CRP: p=0.14). Cardiac baroreflex sensitivity was lower in obese adults (14±2 vs 24±2 ms/mmHg, p=0.02), whereas sympathetic baroreflex sensitivity was higher in obese adults (−3.6±0.5 vs −2.1±0.5 bursts/100 beats/mmHg, p=0.03) when compared to lean. There was no effect of IBU on cardiac or sympathetic baroreflex sensitivity in either group (p-value range 0.20 – 0.71). Conclusion Despite obese individuals exhibiting higher levels of systemic inflammation and lower cardiac baroreflex sensitivity when compared to lean adults, an acute dose of IBU has no effect on cardiac or sympathetic baroreflex sensitivity.

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Association of sympathovagal imbalance with obesity indices, and abnormal metabolic biomarkers and cardiovascular parameters

Cited by 39 publications

References 43 publications

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

¿Es la grasa abdominal subcutánea un predictor de la variabilidad cardíaca en hombres con bajo riesgo metabólico?

Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults

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