Association of symptoms with Helicobacter pylori infection in children

Gormally, Siobhan; Prakash, Nan; Durnin, Marie; Daly, Leslie; Clyne, Marguerite; Kierce, B.; Drumm, Brendan

doi:10.1016/s0022-3476(95)70405-1

Cited by 81 publications

(43 citation statements)

References 16 publications

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“…Several studies suggest progressive gastric mucosal damage induced by this pathogen [5], since clinical symptoms of gastric disorders appear most frequently in adults, while H. pylori acquisition occurs in childhood [6]. However, the role of H. pylori in the genesis of gastric disorders in children and in adults is still controversial, since there is no specific clinical manifestation related to H. pylori infection and not all infected people develop gastric problems [7]. Host-pathogen interactions involving environmental, host and bacterial factors seem to contribute to the onset and progression of gastric diseases.…”

mentioning

confidence: 99%

cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis

Gatti

Labio²,

Silva³

et al. 2006

Braz J Infect Dis

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Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. Onehundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development.

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confidence: 99%

cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis

Gatti

Labio²,

Silva³

et al. 2006

Braz J Infect Dis

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“…pylori infection in children is mostly asymptomatic and not associated with specific gastrointestinal symptoms [44] . H. pylori gastritis, in the absence of duodenal ulcer, does not appear to be associated with specific symptoms [11,[45][46][47][48][49] . After eradication of H. pylori infection, symptoms are improved only in those children with duodenal disease [46] .…”

Section: Symptomsmentioning

confidence: 99%

“…H. pylori gastritis, in the absence of duodenal ulcer, does not appear to be associated with specific symptoms [11,[45][46][47][48][49] . After eradication of H. pylori infection, symptoms are improved only in those children with duodenal disease [46] . Children with H. pylori gastritis cannot be distinguished from noninfected children on the basis of initial symptoms [45,49] .…”

Section: Symptomsmentioning

confidence: 99%

Helicobacter pyloriinfection

Vandenplas¹

2000

WJG

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“…The evidence is even less definitive in children; up to 40% have been reported to continue to have abdominal pain in the face of H pylori eradication (48). Moreover, there are few validated and reproducible 'quality of life' measures or symptom scoring instruments that can be employed as a reliable outcome measure for evaluating the success or failure of eradication therapy in a child with abdominal pain and H pylori infection.…”

Section: What Conditions Have Evidence-based Justification For Initiamentioning

confidence: 99%

Current Therapy forHelicobacter pyloriInfection in Children and Adolescents

Gold

1999

Canadian Journal of Gastroenterology

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Helicobacter pyloriinfects approximately 50% of the world’s population and is a definitive cause of gastroduodenal disease (ie, gastritis, duodenal and gastric ulcers) in children and adults. Four consensus conferences held around the globe have brought together clinicians, scientists, epidemiologists and health care economists to discuss the role of the gastric pathogenH pyloriin human gastroduodenal disease. At each of these conferences, the overriding objective was to reach a consensus on the development of practical guidelines for the diagnosis and treatment ofH pylori-infected individuals. However, it was not until the CanadianH pyloriConsensus Conference, held in November 1997, that the issues ofH pyloriinfection in children were addressed. Therapies forH pyloriinfection in children, presented in part at the First Canadian PaediatricH pyloriConsensus Conference, held in Victoria, British Columbia, November 1998, are reviewed in this paper.

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Association of symptoms with Helicobacter pylori infection in children

Cited by 81 publications

References 16 publications

cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis

cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis

Helicobacter pyloriinfection

Current Therapy forHelicobacter pyloriInfection in Children and Adolescents

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