“…In the case of chronic kidney disease, the highest prevalence is observed in 60-90% of uremic patients in dialysis treatment, the cause is related to alterations in the balance of sodium, phosphorus, and magnesium, in addition to the release of proinflammatory cytokines and histamine 12 . Other systemic disorders include hypothyroidism, iron deficiency anemia, polycythemia, lymphoproliferative and myeloproliferative disorders, atopic dermatitis and ichthyosis, lichen simplex chronicus (LSC), cutaneous infections, psoriasis, hives, insect bite prurigo, and drug-induced skin reactions, among others 13 .…”