Association of systemic lupus erythematosus with hearing loss: a systemic review and meta-analysis

Paraschou, Vasileios; Chaitidis, Nikolaos; Papadopoulou, Zoi; Theocharis, Patroklos; Siolos, Pavlos; Festas, Charalampos

doi:10.1007/s00296-021-04788-5

Cited by 9 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 Its etiology includes genetic and environmental factors, and the interaction of innate and adaptative cellular responses, leading to increased tissue damage, inflammation and multiorgan compromise. 16,17 An increased action of autoantibodies called anti-DNA in SLE leads to increased production of oxidative processes, apoptosis of cochlear hair cells, in addition to increased deposition of the immune complexes at the microvessels and reduction of the vessel's caliber and decreased oxygenation to the inner ear. 16,17 The use of ototoxic drugs in sustained remission episodes, including antimalarials, may affect the cochlea and the cochlear nerve, inducing sensorineural hearing loss.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…16,17 An increased action of autoantibodies called anti-DNA in SLE leads to increased production of oxidative processes, apoptosis of cochlear hair cells, in addition to increased deposition of the immune complexes at the microvessels and reduction of the vessel's caliber and decreased oxygenation to the inner ear. 16,17 The use of ototoxic drugs in sustained remission episodes, including antimalarials, may affect the cochlea and the cochlear nerve, inducing sensorineural hearing loss. 17 A crosssectional study conducted in Brazil that included 43 patients with SLE, an attempt was made to evaluate the auditory function of patients with this pathology who were using antimalarials.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…16,17 The use of ototoxic drugs in sustained remission episodes, including antimalarials, may affect the cochlea and the cochlear nerve, inducing sensorineural hearing loss. 17 A crosssectional study conducted in Brazil that included 43 patients with SLE, an attempt was made to evaluate the auditory function of patients with this pathology who were using antimalarials. In this sample, 37/43 patients (86%) used chloroquine or hydroxychloroquine for more than seven years, these 7/37 (18.9%) presented sensorineural hearing loss, while in the group that did not use antimalarials, half presented sensorineural hearing loss (3/6=50%).…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…The most common audio vestibular finding in SLE is sensorineural hearing loss, with an estimated prevalence of 6-70%. 16,17 The onset of hearing loss in SLE may be progressive or sudden in some specific cases, being in most of the patients with bilateral predominance. 16 Asymptomatic hearing loss is widely reported in patients with SLE.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

“…16,22 However, despite large number of patients with SLE who present hearing disorders, there is no standard treatment focused. 16,17 Table 2 shows summary of results of some studies that address this topic. 20 Brazil 90 -+ -+ + Karatas, 2007 39 Turkey 56 -+ -+ + Maciaszczyk, 2011 28 Poland 67 -+ -+ + Abbasi, 2013 15 Iran 90 -+ -+ NE Batuecas, 2013 40 Spain 89 -+ --+ Rahne, 2017 37 Germany 23 The current prevalence in the United Stated ranges from 4-12 people per 1.000.000 inhabitants per year.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

See 4 more Smart Citations

Audiovestibular manifestations in patients with rheumatologic diseases: a review

Palacio

Madrigal²,

García

et al. 2023

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

Rheumatologic disorders are chronic and systemic disorders with an estimated global prevalence of 3,200 per 100,000 inhabitants. Several clinical manifestations are known and may lead to physical disability and altered quality of life. The most common audio vestibular manifestations commonly reported are hearing loss, tinnitus, vertigo, and fullness, however, there are some more still unregistered. The aim of this review is to describe the most common audio vestibular features in three of the most common rheumatologic conditions such as rheumatoid arthritis (RA), systemic erythematous lupus and systemic sclerosis (SSc). A literature search was performed with articles published between 2000 to 2021. In this literature review an increased prevalence of hearing loss for RA of 40% and 70% for systemic erythematous lupus was observed. In SSc, due to its early onset and progression, there is no estimated prevalence, however, a notorious hearing impairment in early stages of the disease was described. Vertigo was also described in these disorders, affecting more than 60% of patients. Further studies are in need to describe the affection on early stages of all disorders as well as its progression.

show abstract

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

See 3 more Smart Citations

Audiovestibular manifestations in patients with rheumatologic diseases: a review

Palacio

Madrigal²,

García

et al. 2023

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Consideration of health inequity in systematic reviews and primary studies on risk factors for hearing loss

Briscoe,

Shaw,

Nunns

et al. 2024

Cochrane Evidence Synthesis and Methods

View full text Add to dashboard Cite

BackgroundHealth inequities are systematic, avoidable, and unfair differences in health between populations or population subgroups. There is increased recognition of the need for systematic reviews (SRs) to address health inequities, including drawing out findings relevant to low‐ and middle‐income countries (LMICs). The aim of this study was to determine the extent to which SRs on risk factors for hearing loss reported findings associated with health inequities, and the extent to which this data was captured in the primary studies included within these SRs.MethodsWe identified SRs on risk factors for hearing loss from a report on this topic which included a systematic search for relevant SRs. SRs thus identified were inspected for data related to health inequity with reference to PROGRESS‐Plus. We compared how data were reported in SRs versus within primary studies included in the SRs, and the extent to which primary studies from LMICs were represented.ResultsWe included 17 SRs which reported findings on a variety of physiological, behavioral, demographic, and environmental risk factors for hearing loss. There were 296 unique primary studies included in the SRs, of which 251 (81.49%) were successfully retrieved. Data relating to health inequities was reported relatively infrequently in the SRs and mainly focused on gender and age. Data related to health inequities was more frequently reported in primary studies. However, several PROGRESS‐Plus criteria were only reported in a minority of primary studies. Approximately one‐third of primary studies were from LMICs.ConclusionsThere is scope to improve the reporting of data relating to health inequities in primary studies on risk factors for hearing loss. However, SR authors could do more to report health inequities than is currently undertaken, including drawing out findings relevant to LMICs where data are available.

show abstract

Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

Xu,

Liao,

Zhang

et al. 2024

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectiveWe aimed to investigate the potential environmental risk factors, protective factors, and biomarkers of hearing loss (HL), and establish a hierarchy of evidence.Data SourcesEmbase, PubMed, Cochrane Library, and Web of Science electronic database from inception to June 1, 2023.Review MethodsWe included meta‐analyses of observational studies of associations between HL and environmental risk factors, protective factors, or biomarkers. We calculated summary effect estimates, 95% confidence interval, heterogeneity I2 statistic, 95% prediction interval, small study effects, and excess significance biases.ResultsOf the 9211 articles retrieved, 60 eligible articles were included. The 60 eligible articles identified 47 potential environmental risk and protective factors (N = 4,123,803) and 46 potential biomarkers (N = 173,701). Evidence of association was convincing (class I) for rheumatoid arthritis (RA) and every 1 cm increase in height. Evidence of association was highly suggestive (class II) for human immunodeficiency virus (HIV), diabetes, cumulative noise exposure (CNE), smoking, congenital cytomegalovirus (CMV) infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and alopecia areata (AA).ConclusionIn this umbrella review, RA, every 1 cm increase in height, HIV, diabetes, CNE, smoking, congenital CMV infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and AA were strongly associated with HL.

show abstract

Association of systemic lupus erythematosus with hearing loss: a systemic review and meta-analysis

Cited by 9 publications

References 37 publications

Audiovestibular manifestations in patients with rheumatologic diseases: a review

Audiovestibular manifestations in patients with rheumatologic diseases: a review

Consideration of health inequity in systematic reviews and primary studies on risk factors for hearing loss

Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

Contact Info

Product

Resources

About