Association of tag single nucleotide polymorphisms (SNPs) at lncRNA MALAT1 with type 2 diabetes mellitus susceptibility in the Chinese Han population: A case-control study

Chang, Weiwei; Zhang, Liu; Wen, Li-ying; Huang, Qian; Tong, Xin; Tao, Yu-jing; Chen, Guimei

doi:10.1016/j.gene.2022.147008

Cited by 5 publications

(3 citation statements)

References 61 publications

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“…After screening the database for evidence of SNPs in MALAT1 and H19 genes that have an association with obesity and metabolic dysregulation, two candidate SNPs were selected: rs3200401 in MALAT1 and rs217727 in H19. The rs3200401 and rs217727 had been, in other studies and populations, reported to be associated with abnormal lipid profile and metabolic disorders such as T2D [14,23,24].…”

Section: Snp Selectionmentioning

confidence: 79%

“…Another study showed that H19 rs217727 may alter a local folding structure of lncRNA H19, thus affecting the functional interactions of H19 [39]. The SNPs rs3200401 in MALAT1 and rs217727 in H19 are associated with an increased risk of T2D and an irregular lipid profile [23,24]. However, no research has previously been conducted to evaluate their association with an individual's susceptibility to childhood obesity, at least among Russian children.…”

Section: Discussionmentioning

confidence: 99%

“…Genetic polymorphisms in lncRNAs may influence their expression and function, and thus increase or decrease an individual's susceptibility to the disease, to the extent that the lncRNAs are the direct causative contributors rather than mere genetic markers; this feature would help to assess disease risk and clinical prognosis [21,22]. The SNPs rs3200401 in MALAT1 and rs217727 in H19 are associated with increased risk of T2D [23,24] and different types of cancers [25,26]. Several studies have suggested that there is association between the SNPs rs3200401 and rs217727, and the etiological mechanisms of obesity, such as insulin dysregulation, and abnormal lipid and glucose metabolism [13,20,24].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Genetic Variants in the Long Non-Coding RNA Genes MALAT1 and H19 in the Pathogenesis of Childhood Obesity

Шкурат

Ammar

Bocharova

et al. 2023

ncRNA

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Long non-coding RNAs (lncRNAs) play important roles in the maintenance of metabolic homeostasis. Recently, many studies have suggested that lncRNAs, such as Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and Imprinted Maternally Expressed Transcript (H19), might participate in the pathogenesis of metabolic disorders such as obesity. We conducted a case-control study with 150 Russian children and adolescents aged between 5 and 17 years old in order to assess the statistical association between the single nucleotide polymorphisms (SNPs) rs3200401 in MALAT1 and rs217727 in H19, and the risk of developing obesity in this population. We further explored the possible association of rs3200401 and rs217727 with BMI Z-score and insulin resistance. The MALAT1 rs3200401 and H19 rs217727 SNPs were genotyped using Taqman SNP genotyping assay. The MALAT1 rs3200401 SNP was identified as a risk factor for childhood obesity (p < 0.05) under the dominant and allelic models, and the CT heterozygous genotype was associated with the risk of increased BMI and with insulin resistance. The H19 rs217727 SNP had no significant association with obesity risk (all p > 0.05). Our findings thus suggest that MALAT1 SNP rs3200401 is a potential indicator of obesity susceptibility and pathogenesis in children and adolescents.

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Section: Snp Selectionmentioning

confidence: 79%