Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China

Abstract

Background: Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been reported to be strongly associated with type 2 diabetes mellitus (T2DM) in Icelandic, Danish and American populations and further replicated in other European populations, African Americans, Mexican Americans, and Asian populations. The aim of the present study was to investigate the association of TCF7L2 gene polymorphisms with T2DM in a Uygur population of China. Methods: 877 T2DM patients and 871 controls were selected for the present study. Two single nucleotide polymorphisms (SNPs) (rs12255372 and rs7901695) were genotyped by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. The associations of SNPs and haplotypes with T2DM and linkage disequilibrium (LD) structure of the TCF7L2 gene were analyzed. Results: For total participants and male, the distribution of rs12255372 alleles and the dominant model (Guanine Guanine (GG) genotype vs. Guanine Thymine (GT) genotype + Thymine Thymine (TT) genotype) showed significant difference between T2DM and control subjects (for allele: p = 0.013 and p = 0.002, respectively; for dominant model: p = 0.028 and p = 0.008, respectively). The distribution of rs7901695 alleles and the dominant model (TT genotype vs. Thymine Cytosine (TC) genotype + Cytosine Cytosine (CC) genotype) for total participants and male showed significant difference between T2DM and control subjects (for allele: both p = 0.001; for dominant model: p = 0.006 and p = 0.008, respectively). Conclusions: Our data suggested that the genetic polymorphisms of the TCF7L2 gene were associated with T2DM in the Uygur population of China.

Association between transcription factor 7-like 2 genetic polymorphisms and development of type 2 diabetes in a Chinese population

“…To date, several studies have tested the association between TCF7L2 genetic variations and risk of developing type 2 diabetes mellitus (Assmann et al, 2014;Barros et al, 2014;OuhaibiDjellouli et al, 2014;Guewo-Fokeng et al, 2015;Nanfa et al, 2015;Yang et al, 2015;Yao et al, 2015). Assmann et al (2014), Guewo-Fokeng et al (2015), and Ouhaibi-Djellouli et al (2014) conducted investigations to assess the role of the TCF7L2 rs7903146 polymorphism in the pathogenesis of this disease, reporting that this sequence variant is associated with susceptibility to type 2 diabetes mellitus in Caucasians.…”

“…Assmann et al (2014), Guewo-Fokeng et al (2015), and Ouhaibi-Djellouli et al (2014) conducted investigations to assess the role of the TCF7L2 rs7903146 polymorphism in the pathogenesis of this disease, reporting that this sequence variant is associated with susceptibility to type 2 diabetes mellitus in Caucasians. In studies of Chinese populations, Yao et al (2015) and Yang et al (2015) determined that the TCF7L2 rs12255372 polymorphism may also contribute to the risk of developing this condition. However, some investigations have reached inconsistent conclusions (Barros et al, 2014;Pourahmadi et al, 2015).…”

“…TCF7L2 expression is related to its proposed function in insulin secretion. Several previous studies have examined the role of the TCF7L2 rs7903146 polymorphism in the development of type 2 diabetes mellitus, but their results have been inconclusive (Assmann et al, 2014;Barros et al, 2014;Allahdini et al, 2015;GuewoFokeng et al, 2015;Liu et al, 2015;Nanfa et al, 2015;Yao et al, 2015;Yang et al, 2015). In this study, we conducted a hospital-based case-control investigation to evaluate the relationship between TCF7L2 rs7903146 and risk of developing type 2 diabetes mellitus in a Chinese population.…”

Metabolic Risk Factors of Type 2 Diabetes Mellitus and Correlated Glycemic Control/Complications: A Cross-Sectional Study between Rural and Urban Uygur Residents in Xinjiang Uygur Autonomous Region

“…Originating from inter-marriage between Caucasians and Mongolians, the Uygur people have their own language, culture, genetic background, lifestyle, and dietary habits. Previous reports showed differences between Uygur and Han regarding the prevalence of T2DM [ 25 ] and genetic polymorphism [ 26 , 27 ]. The current study sought to assess the differences in prevalence of T2DM and metabolic risk factors among general and diabetic populations and their variations across compared populations in Xinjiang, China, drawn from urban and rural Uygur settlements.…”

A tale of agriculturalists and hunter‐gatherers: Exploring the thrifty genotype hypothesis in native South Americans

“…TCF7L2 (chr10: 112,950,250‐113,167,678/hg38), transcription factor 7‐like 2, is a component of the Wnt pathway, and variants in this locus have been strongly associated with type 2 diabetes mellitus (T2D) across different world populations and ethnic groups (Grant et al, ; Yao et al, ). Miyake et al () and Ng et al () studied the intronic polymorphism rs11196205 C > G and suggested an association between the ancestral allele C and higher risk of T2D in Hong Kong Chinese and Japanese patients.…”