2019
DOI: 10.2298/gensr1902701j
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Association of TGF-β1 and TNF-α genes polymorphisms with the kidney scars forming risk in children with vesicoureteral reflux

Abstract: Matrix accumulation in the tissue is the main pathological feature of fibrosis. TGF-β1 stimulates the production of extracellular matrix protein and induces fibrosis in different tissues. TNF-α is a proinflammatory cytokine produced in the kidneys by proximal tubular cells, mesenchymal cells, interstitial fibroblasts and macrophages. The aim of this study was to investigate the association of TGF-β1 and TNF-α genes polymorphisms with the risk of developing kidney scars in children with vesicoureteral reflux (V… Show more

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