Association of the -844G&gt;A polymorphism in the catalase gene with the increased risk of essential hypertension in smokers

Бушуева, О. Ю.; Иванов, В. П.; Ryzhaeva, V N; Ponomarenko, Irina; Churnosov, Mikhail; Чурносов, М И; Polonikov, Alexey; Полоников, А В

doi:10.17116/terarkh201688950-54

Cited by 5 publications

(4 citation statements)

References 28 publications

(44 reference statements)

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“…In the present research, we also report environmentally-dependent effects of HSPA8 polymorphisms. It is known that environmental risk factors can modify the contribution of genetic variants on the risk of diseases [ 28 , 73 , 74 ]. Our study provided significant evidence of the role of smoking and low consumption of fresh vegetables and fruits in the manifestation of associations rs10892958 and rs1136141 HSPA8 and the development of IS.…”

Section: Discussionmentioning

confidence: 99%

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

Kobzeva

Soldatova

Stetskaya

et al. 2023

Genes

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HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether HSPA8 SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the HSPA8 gene using probe-based PCR. SNP rs10892958 of HSPA8 was associated with an increased risk (risk allele G) of IS in smokers (OR = 1.37; 95% CI = 1.07–1.77; p = 0.01) and patients with low fruit and vegetable consumption (OR = 1.36; 95% CI = 1.14–1.63; p = 0.002). SNP rs1136141 of HSPA8 was also associated with an increased risk of IS (risk allele A) exclusively in smokers (OR = 1.68; 95% CI = 1.23–2.28; p = 0.0007) and in patients with a low fruit and vegetable intake (OR = 1.29; 95% CI = 1.05–1.60; p = 0.04). Sex-stratified analysis revealed an association of rs10892958 HSPA8 with an increased risk of IS in males (risk allele G; OR = 1.30; 95% CI = 1.05–1.61; p = 0.01). Thus, SNPs rs10892958 and rs1136141 in the HSPA8 gene represent novel genetic markers of IS.

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Section: Discussionmentioning

confidence: 99%

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

Kobzeva

Soldatova

Stetskaya

et al. 2023

Genes

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“…В настоящее время накоплено достаточно данных, указывающих на значительную роль наследственных факторов в развитии и прогрессировании АГ [7][8][9]. Полученные результаты расширяют эти представления, демонстрируя наличие статистически значимых связей между полиморфизмом генов, участвующих в патогенезе АГ, и ПОМ.…”

Section: Discussionunclassified

Relationship of gene polymorphism with the nature of target organ damage in patients with arterial hypertension

Drobotya

Arutyunyan²,

Пироженко

et al. 2020

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Objective: to assess the relationship of polymorphism of the main genes involved in the pathogenesis of arterial hypertension (AH) with indicators reflecting the state of target organs in the group of patients with arterial hypertension.Material and methods: we examined 100 patients with arterial hypertension who underwent standard diagnostic procedures, as well as molecular genetic research.Results: in patients with arterial hypertension statistically significant associations of AGTR2, GNB3, and NOS3 gene polymorphism with left ventricular hypertrophy, CYP11B2 and NOS3 gene polymorphism with left ventricular diastolic dysfunction, and NOS3 gene polymorphism with increased vascular wall stiffness were found (p < 0.05).Conclusions: the results of the study indicate that patients with arterial hypertension are a genetically heterogeneous group in terms of the relationship of specific gene polymorphism with indicators that characterize the state of target organs. The use of genetic approaches is promising for early screening of patients with arterial hypertension, belonging to the high-risk group, in order to ensure timely and effective organoprotection.

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“…Increased ROS production is involved in the pathogenesis of many 1,5,8–17,22,23,25,28–44,48,57,60,62–64,68,71,72,86,89,92,104,138,140–154,162,163,173,189,197,210,214,218,219,221–233,236–244,246–252,262,263 270–273,278–280,295,305329–331 ,.…”

Section: Introductionmentioning

confidence: 99%

“…Catalase (CAT) catalyzes the conversion of H 2 O 2 to water and oxygen. SNPs in the CAT gene promoter region, CAT -844 AA and CAT -262 CT or TT, have been associated with essential hypertension among Chinese 157 , smoking Russians 154 , Greeks 155 , but not African-Americans and Caucasians 156 . However, CAT haplotype [−844G,−89A,−20T] relative to the CAT haplotype [−844A,−89T,−20C] was predictive of a decrease in diastolic blood pressure after bariatric surgery in a French population 378 .…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation

2019

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Hypertension is the most prevalent cause of cardiovascular disease and kidney failure but only about 50% of patients achieve adequate blood pressure control, in part, due to inter-individual genetic variations in the response to antihypertensive medication. Significant strides have been made toward the understanding of the role of reactive oxygen species (ROS) in the regulation of the cardiovascular system. However, the role of ROS in human hypertension is still unclear. Polymorphisms of some genes involved in the regulation of ROS production are associated with hypertension, suggesting their potential influence on blood pressure control and response to antihypertensive medication. This review provides an update on the genes associated with the regulation of ROS production in hypertension and discusses the controversies on the use of antioxidants in the treatment of hypertension, including the antioxidant effects of antihypertensive drugs.

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Association of the -844G>A polymorphism in the catalase gene with the increased risk of essential hypertension in smokers

Cited by 5 publications

References 28 publications

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

Relationship of gene polymorphism with the nature of target organ damage in patients with arterial hypertension

Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation

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