Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children

Zhao, Jie; Zhang, Wen; Shen, Li; Yang, Xiaomeng; Liu, Yi; Gai, Zhongtao

doi:10.1097/md.0000000000006642

“…IL-6 plays an important role in the pathogenesis of MPP [7] . Our previous research suggested that IL-6-174 G/C genotype increased MP infection in patients [17] , which also suggested that IL-6 was closely related to MP infection. In the research, IL-6s in BALFs was significantly higher in patients with MPP than those in control.…”

Section: Discussionmentioning

confidence: 89%

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

Zhao

¹

,

Li

²

,

Zhang³

2020

Preprint

Self Cite

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Backgrounds: IL-6 is associated with the severity of mycoplasma pneumoniae pneumonia (MPP). But the relationship between IL-27 and MPP was unknown. Methods: 98 patients with MPP < 14 years old were enrolled in this study and divided into groups by severity (mild cases and severe cases), infection types (MP single infection group and MP mixed infection group) and DNA loads (low MP DNA loads group and high MP DNA loads group), respectively. 15 children with foreign bodies in bronchus were also enrolled as control. IL-6s and IL-27s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA. Results: There were significant differences in IL-6s of BALFs from patients between mild cases and severe cases, MP single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, respectively (P﹤0.05). Compared with IL-6s of BALFs from control, IL-6 in BALFs from the 6 patient groups were significantly higher (P﹤0.05). IL-27s in BALFs from MP mixed infection group were significantly lower than those from MP single infection group and control (P﹤0.05) respectively. Conclusion: IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to MP infection.

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“…IL-6 plays an important role in the pathogenesis of MPP [7] . Our previous research suggested that the IL-6-174 G/C genotype increased the infection of MP in patients [17] , which also suggested that IL-6 was closely related to MP infection.…”

Section: Discussionmentioning

confidence: 91%

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

Zhao

¹

,

Li

²

,

Zhang³

2020

Preprint

Self Cite

0

View full text Add to dashboard Cite

Backgrounds: IL-6 is associated with the severity of mycoplasma pneumoniae pneumonia (MPP). But the relationship between IL-27 and MPP was unknown.Methods: 98 patients with MPP who were under 14 years old, were enrolled in this study and divided into mild cases and severe cases, Mycoplasma pneumoniae (MP) single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, by severity, infection types and DNA loads respectively. 15 children with foreign bodies for bronchus were also enrolled as control. IL-6s and IL-27s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA.Results: There were significant differences in IL-6s of BALFs from patients between mild cases and severe cases, MP single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, respectively (P 0.05). Compared with IL-6s of BALFs from control, IL-6 in BALFs from the 5 patient groups were significantly higher (P 0.05) except that from low MP DNA loads group. IL-27s in BALFs from MP mixed infection group were significantly lower than those from MP single infection group and control (P 0.05) respectively.Conclusion: IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to MP infection. BackgroundMycoplasma pneumoniae (MP) is one of the main pathogens in respiratory infections in children. It causes more than 40% of community-acquired pneumonia (CAP) cases in children and 18% of these cases need hospitalization [1] . At present there have been many problems with patients suffering from Mycoplasma pneumoniae pneumonia (MPP) such as the increasing macrolide resistance rate [2] , the complex multiple systemic complications [3] , the increasing occurrence of refractory MPP [4] .Therefore, MPP has attracted great attentions from many researchers and patients. It is widely recognized that immune function disorders have been involved in the pathogenesis of MPP [5] . And IL-6 is an important cytokine which can regulate immune function [6] . It is involved in the infection process of MP and plays an important role in the pathogenesis of MPP [7] . One study suggested that

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“…IL-6 plays an important role in the pathogenesis of MPP [7] . Our previous research suggested that the IL-6-174 G/C genotype increased the infection of MP in patients [14] , which also suggested that IL-6 was closely related to MP infection.…”

Section: General Informationmentioning

confidence: 91%

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

Zhao

¹

,

Li

²

,

Zhang³

2019

Preprint

Self Cite

0

View full text Add to dashboard Cite

Backgrounds: IL-6 is associated with the severity of mycoplasma pneumoniae pneumonia (MPP). But the relationship of IL-27 and MPP was unknown. Methods: 98 patients with MPP younger than 14 years old were enrolled in this study and divided into mild cases and severe cases by severity of disease, MP single infection group and MP mixed infection group by MP mixed-infection types, and low MP DNA loads group and high MP DNA loads group by MP DNA loads respectively. 15 children with foreign bronchus bodies were also enrolled as control. The levels of IL-6 and IL-27 in BALFs collected from these children were assayed by ELISA. Results: There were significant differences in the levels of IL-6 in BALFs from patients between 3 patient groups, respectively ( P 0.05). Compared with the levels of IL-6 in BALFs from control, the levels of IL-6 in BALFs from the 5 groups were significantly higher ( P 0.05) except that from low MP DNA loads group. The levels of IL-27 in BALFs from MP mixed infection group were significantly higher than those from MP single infection group and control( P 0.05).Conclusion: IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not associated with MP infection. BackgroundMycoplasma pneumoniae (MP) is a main pathogen in respiratory infections in children. It causes more than 40% of community-acquired pneumonia (CAP) cases in children and 18% of these cases needs hospitalization [1] . At present there have been many problems with patients suffering from Mycoplasma pneumoniae pneumonia (MPP) such as the increasing macrolide resistance rate [2] , the complex multiple systemic complications [3] , the increasing occurrence of refractory MPP [4] .Therefore, MPP has attracted the great attention of many researchers and patients. It is widely recognized that immune function disorders have been involved in the pathogenesis of MPP [5] . And IL-6 is an important cytokine which can regulate immune function [6] . It was involved in the infection process of MP and played an important role in the pathogenesis of MPP [7] . One study suggested that IL-6 was associated with the severity of MPP [8] . IL-27 could induce the secretion of IL-6 [9] and block the activity of IL-6 by its subunit of IL-27 p28 [10] . Therefore, we inferred that IL-27 might be involved

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Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children

Cited by 29 publications

References 28 publications

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

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